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Altered plasma levels of chemokines in autism and their association with social behaviors
Yidong Shen1,2,3,4; JInajunOu1,2,3,4; MengmengLiu1,2,3,4; LijuanShi1,2,3,4,5; YaminLi1,2,3,4; LuXiao1,2,3,4; HuixiDong1,2,3,4; FengyuZhang1,2,3,4,6; KunXia7; Jingping Zhao1,2,3,4,7; J. Zhao
2016
发表期刊Psychiatry Research
通讯作者邮箱zhaojingpingcsu@163.com
ISSN0165-1781
卷号244期号:30页码:300-305
摘要

Autism Spectrum Disorder (ASD) is a group of neurodevelopment disorders with an unclear etiology. Chemokines have been implicated in the etiology and pathogenesis of ASD. The current study investigated the plasma levels of seven chemokines (RANTES, Eotaxin, MIP-1 α, MIP-1 β, MCP-1, IP-10, and MIG) in 42 young autistic patients and 35 age-matched typically developing (TD) children. The study also tested the association between these chemokine levels and social behaviors, as measured by the Social Responsiveness Scale (SRS). Compared to the TD children, RANTES, MIP-1α, and MIP-1β were higher, while IP-10 and MIG were lower in the autistic patients, after correcting for multiple comparisons. Among these seven chemokines, MIP-1α, MIP-1β and IP-10 levels were found to be associated with social behaviors in all the participants. Moreover, MIP-1α and IP-10 were found to be independent predictors of social behaviors. The results of our study support the hypothesis that altered chemokine levels are involved in the pathophysiology of ASD and they indicate that chemokines plasma levels could be potential biomarkers for ASD.

关键词Autism Chemokines Social behavior Biomarker
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25596
专题脑与认知科学国家重点实验室
通讯作者J. Zhao
作者单位1.KeyLaboratoryofPsychiatryandMentalHealthofHunanProvince,Changsha,China
2.The NationalTechnologyInstituteofPsychiatry,China
3.The NationalClinicalResearchCenterforMentalHealthDisorders,China
4.Institute ofMentalHealth,theSecondXiangyaHospital,CentralSouthUniversity,China
5.NeuropsychologyandAppliedCognitiveNeuroscienceResearchGroup,InstituteofPsychology,ChineseAcademyofSciences,Beijing,China
6.Lieber InstituteforBrainDevelopment,JohnsHopkinsUniversityMedicalCampus,Baltimore,MD,USA
7.State KeyLaboratoryofMedicalGenetics,CentralSouthUniversity,Changsha,China
推荐引用方式
GB/T 7714
Yidong Shen,JInajunOu,MengmengLiu,et al. Altered plasma levels of chemokines in autism and their association with social behaviors[J]. Psychiatry Research,2016,244(30):300-305.
APA Yidong Shen.,JInajunOu.,MengmengLiu.,LijuanShi.,YaminLi.,...&J. Zhao.(2016).Altered plasma levels of chemokines in autism and their association with social behaviors.Psychiatry Research,244(30),300-305.
MLA Yidong Shen,et al."Altered plasma levels of chemokines in autism and their association with social behaviors".Psychiatry Research 244.30(2016):300-305.
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