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Altered plasma levels of chemokines in autism and their association with social behaviors
Yidong Shen1,2,3,4; JInajunOu1,2,3,4; MengmengLiu1,2,3,4; LijuanShi1,2,3,4,5; YaminLi1,2,3,4; LuXiao1,2,3,4; HuixiDong1,2,3,4; FengyuZhang1,2,3,4,6; KunXia7; Jingping Zhao1,2,3,4,7; J. Zhao
2016
Source PublicationPsychiatry Research
Correspondent Emailzhaojingpingcsu@163.com
ISSN0165-1781
Volume244Issue:30Pages:300-305
Abstract

Autism Spectrum Disorder (ASD) is a group of neurodevelopment disorders with an unclear etiology. Chemokines have been implicated in the etiology and pathogenesis of ASD. The current study investigated the plasma levels of seven chemokines (RANTES, Eotaxin, MIP-1 α, MIP-1 β, MCP-1, IP-10, and MIG) in 42 young autistic patients and 35 age-matched typically developing (TD) children. The study also tested the association between these chemokine levels and social behaviors, as measured by the Social Responsiveness Scale (SRS). Compared to the TD children, RANTES, MIP-1α, and MIP-1β were higher, while IP-10 and MIG were lower in the autistic patients, after correcting for multiple comparisons. Among these seven chemokines, MIP-1α, MIP-1β and IP-10 levels were found to be associated with social behaviors in all the participants. Moreover, MIP-1α and IP-10 were found to be independent predictors of social behaviors. The results of our study support the hypothesis that altered chemokine levels are involved in the pathophysiology of ASD and they indicate that chemokines plasma levels could be potential biomarkers for ASD.

KeywordAutism Chemokines Social behavior Biomarker
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25596
Collection脑与认知科学国家重点实验室
Corresponding AuthorJ. Zhao
Affiliation1.KeyLaboratoryofPsychiatryandMentalHealthofHunanProvince,Changsha,China
2.The NationalTechnologyInstituteofPsychiatry,China
3.The NationalClinicalResearchCenterforMentalHealthDisorders,China
4.Institute ofMentalHealth,theSecondXiangyaHospital,CentralSouthUniversity,China
5.NeuropsychologyandAppliedCognitiveNeuroscienceResearchGroup,InstituteofPsychology,ChineseAcademyofSciences,Beijing,China
6.Lieber InstituteforBrainDevelopment,JohnsHopkinsUniversityMedicalCampus,Baltimore,MD,USA
7.State KeyLaboratoryofMedicalGenetics,CentralSouthUniversity,Changsha,China
Recommended Citation
GB/T 7714
Yidong Shen,JInajunOu,MengmengLiu,et al. Altered plasma levels of chemokines in autism and their association with social behaviors[J]. Psychiatry Research,2016,244(30):300-305.
APA Yidong Shen.,JInajunOu.,MengmengLiu.,LijuanShi.,YaminLi.,...&J. Zhao.(2016).Altered plasma levels of chemokines in autism and their association with social behaviors.Psychiatry Research,244(30),300-305.
MLA Yidong Shen,et al."Altered plasma levels of chemokines in autism and their association with social behaviors".Psychiatry Research 244.30(2016):300-305.
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