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Changes of gray matter volume and amplitude of lowfrequency oscillations in amnestic MCI An integrative multimodal MRI study
Zhi-Lian Zhao1,2; Feng-Mei Fan3,4; Jie Lu1,2; Hui-Jie Li4; Long-Fei Jia5; Ying Han6; Kun-Cheng Li1,2
First AuthorZhi-Lian Zhao
Correspondent Emailkuncheng.li@gmail.com
Contribution Rank3
Abstract

Background: Numerous studies have reported that the amnestic-type mild cognitive impairment (aMCI) patients have impaired brain structural integrity and functional alterations separately.
Purpose: To investigate the changes of gray matter and amplitude of low-frequency oscillations in patients with aMCI by combining structural and functional magnetic resonance imaging (fMRI).
Material and Methods: Thirty-four patients with aMCI and 34 controls were recruited.We adopted optimized voxelbased morphometry to detect regions with gray matter volume (GMV) loss induced by aMCI. Then regional differences in amplitude of slow-4 band (0.027–0.073 Hz) oscillations among these regions between patients and healthy controls were examined. Both slow-4 amplitude of low-frequency fluctuations (ALFF) and slow-4 fractional ALFF (fALFF; the relative amplitude that resides in the low frequencies) were employed.
Results: Patients with aMCI demonstrated significant GMV loss in the ventral medial prefrontal cortex (vMPFC), posterior cingulate cortex (PCC), bilateral hippocampus, right superior parietal gyrus, left insula and left middle temporal gyrus (P<0.01). The patients exhibited significant decreases of slow-4 ALFF in the left hippocampus (P¼0.05) and PCC(P¼0.02), while the decreased slow-4 fALFF was detected in PCC (P¼0.01) and increased slow-4 fALFF in vMPFC(P¼0.03). In PCC, aMCI and controls exhibited significant different GMV-fALFF correlation (P<0.05), with opposite correlation trend.
Conclusion: The correlates between anatomical deficits and functional alterations in aMCI suggest that anatomical and functional deficits are linked to each other. The differences of GMV-fALFF correlations demonstrated altered anatomicalfunctional relationship in aMCI.

KeywordaMCI resting-state fMRI low-frequency oscillations VBM
2015
Language英语
Source PublicationActa Radiologica
Volume56Issue:5Pages:614–621
Indexed BySCI
QuartileQ2
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25607
Collection中国科学院行为科学重点实验室
Affiliation1.Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, PR China
2.Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China
3.Key Laboratory of Behavioral Science, Laboratory for Functional Connectome and Development, Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, PR China
4.Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, PR China
5.Department of Neurology, Beijing Tongren Hospital affiliated to Capital Medical University, Beijing, PR China
6.Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, PR China
Recommended Citation
GB/T 7714
Zhi-Lian Zhao,Feng-Mei Fan,Jie Lu,et al. Changes of gray matter volume and amplitude of lowfrequency oscillations in amnestic MCI An integrative multimodal MRI study[J]. Acta Radiologica,2015,56(5):614–621.
APA Zhi-Lian Zhao.,Feng-Mei Fan.,Jie Lu.,Hui-Jie Li.,Long-Fei Jia.,...&Kun-Cheng Li.(2015).Changes of gray matter volume and amplitude of lowfrequency oscillations in amnestic MCI An integrative multimodal MRI study.Acta Radiologica,56(5),614–621.
MLA Zhi-Lian Zhao,et al."Changes of gray matter volume and amplitude of lowfrequency oscillations in amnestic MCI An integrative multimodal MRI study".Acta Radiologica 56.5(2015):614–621.
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