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Cognitive dysfunction and epigenetic alterations at the BDNF gene are induced by social isolation during early adolescence
Man Li1; Wei Du1; Feng Shao1; Weiwen Wang2; F. Shao; W. Wang
2016
发表期刊Behavioural Brain Research
通讯作者邮箱shaof@pku.edu.cn ; wangww@psych.ac.cn
卷号313期号:不详页码:177-183
摘要

Early life adversity, such as social isolation, causes a variety of changes to the development of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic modifications mediate gene-environment interactions throughout the lifespan. In this study, we investigated the effect of adolescent social isolation on cognitive behaviours and epigenetic alterations of the brain-derived neurotrophic factor (BDNF) gene. Male Sprague Dawley rats were randomly assigned to either groupreared or isolation-reared conditions during post-natal days (PNDs) 21–34. On PND 56, all rats underwent behavioural testing and were then sacrificed for biochemical testing. Adolescent social isolation induced impaired PPI. Regarding BDNF, the isolation-reared rats demonstrated increased BDNF mRNA levels, H3 acetylation at the BDNF gene and BDNF protein expression in the medial prefrontal cortex (mPFC). In contrast, the BDNF mRNA levels, H3 acetylation of the BDNF gene and BDNF protein expression were decreased in the hippocampus of the isolation-reared rats. The present study indicated that epigenetic regulation of BDNF may be one of the molecular mechanisms that mediated the cognitive dysfunction. Moreover, the interaction between the mPFC and hippocampus might play an important role in the regulation of cognitive behaviour.

关键词Social isolation Cognitive behaviour Brain-derived neurotrophic factor (BDNF) Epigenetics
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25608
专题中国科学院心理健康重点实验室
通讯作者F. Shao; W. Wang
作者单位1.School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University
2.Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
推荐引用方式
GB/T 7714
Man Li,Wei Du,Feng Shao,et al. Cognitive dysfunction and epigenetic alterations at the BDNF gene are induced by social isolation during early adolescence[J]. Behavioural Brain Research,2016,313(不详):177-183.
APA Man Li,Wei Du,Feng Shao,Weiwen Wang,F. Shao,&W. Wang.(2016).Cognitive dysfunction and epigenetic alterations at the BDNF gene are induced by social isolation during early adolescence.Behavioural Brain Research,313(不详),177-183.
MLA Man Li,et al."Cognitive dysfunction and epigenetic alterations at the BDNF gene are induced by social isolation during early adolescence".Behavioural Brain Research 313.不详(2016):177-183.
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