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Comparison of stressinduced and LPSinduced depressivelike behaviors and the alterations of central proinflammatory cytokines mRNA in rats
Xi-ting Guan1,2; Wen-juan Lin1; Ming-ming Tang1
2015
Source PublicationPsyCh Journal
Correspondent Emaillinwj@psych.ac.cn
Issue4Pages:113–122
Abstract

Although proinflammatory cytokine changes in depression have been studied widely, few investigations have searched for specific and common changes in cytokines. In the present study, two animal models of depression were compared: a chronic stress model using forced swim stress and an immune activation model using repeated central lipopolysaccharide (LPS) infusion. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 mRNA were examined in the brain regions of the prefrontal cortex, amygdala, and hippocampus using real-time polymerase chain reaction (RT-PCR). It was found that both chronic swim stress and repeated central LPS infusion induced depressive-like behaviors, including decreased body weight, reduced saccharin preference, and increased immobility time or shortened latency of immobility in the tail suspension test. Central TNF-α mRNA expression was elevated in both models and central IL-6 mRNA expression was unchanged in both models. Central IL-1β mRNA expression was increased only in the chronic immune activation model. The findings from this study suggest that TNF-α may be a common risk factor for inflammation in depressive disorders.

Keyworddepression immune activation lipopolysaccharide swim stress TNF-α
DOI10.1002/pchj.87
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25609
Collection中国科学院心理健康重点实验室
Affiliation1.Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
2.University of Chinese Academy of Sciences
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Xi-ting Guan,Wen-juan Lin,Ming-ming Tang. Comparison of stressinduced and LPSinduced depressivelike behaviors and the alterations of central proinflammatory cytokines mRNA in rats[J]. PsyCh Journal,2015(4):113–122.
APA Xi-ting Guan,Wen-juan Lin,&Ming-ming Tang.(2015).Comparison of stressinduced and LPSinduced depressivelike behaviors and the alterations of central proinflammatory cytokines mRNA in rats.PsyCh Journal(4),113–122.
MLA Xi-ting Guan,et al."Comparison of stressinduced and LPSinduced depressivelike behaviors and the alterations of central proinflammatory cytokines mRNA in rats".PsyCh Journal .4(2015):113–122.
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