PSYCH OpenIR  > 健康与遗传心理学研究室
Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety
Tseng, Ming-Tsung1,2,3; Kong, Yazhuo2,3,4,5; Eippert, Falk2,3; Tracey, Irene2,3
2017-12-06
Source PublicationJOURNAL OF NEUROSCIENCE
Correspondent Emailmingtsungtseng@ntu.edu.tw.
ISSN0270-6474
SubtypeArticle
Volume37Issue:49Pages:11806-11817
AbstractTo convert a painful stimulus into a briefly maintainable construct when the painful stimulus is no longer accessible is essential to guide human behavior and avoid dangerous situations. Because of the aversive nature of pain, this encoding process might be influenced by emotional aspects and could thus vary across individuals, but we have yet to understand both the basic underlying neural mechanisms as well as potential interindividual differences. Using fMRI in combination with a delayed-discrimination task in healthy volunteers of both sexes, we discovered that brain regions involved in this working memory encoding process were dissociable according to whether the to-be-remembered stimulus was painful or not, with the medial thalamus and the rostral anterior cingulate cortex encoding painful and the primary somatosensory cortex encoding nonpainful stimuli. Encoding of painful stimuli furthermore significantly enhanced functional connectivity between the thalamus and medial prefrontal cortex (mPFC). With regards to emotional aspects influencing encoding processes, we observed that more anxious participants showed significant performance advantages when encoding painful stimuli. Importantly, only during the encoding of pain, the interindividual differences in anxiety were associated with the strength of coupling between medial thalamus and mPFC, which was furthermore related to activity in the amygdala. These results indicate not only that there is a distinct signature for the encoding of a painful experience in humans, but also that this encoding process involves a strong affective component.
Keywordcognition encoding fMRI pain sensation vibration
DOI10.1523/JNEUROSCI.0750-17.2017
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Science Council(100-2917-I-564-028) ; Ministry of Science and Technology(103-2410-H-002-121-MY2) ; National Health Research Institutes of Taiwan(NHRI-EX106-10615NC) ; Marie Curie Fellowship(273805) ; National Institute for Health Research Oxford Biomedical Research Centre ; Medical Research Council of Great Britain and Northern Ireland ; Wellcome Trust (London, UK)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000418053700005
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordMEDIAL PREFRONTAL CORTEX ; PRIMARY SOMATOSENSORY CORTEX ; WORKING-MEMORY ; FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; STIMULATION ; PERCEPTION ; ATTENTION ; DISCRIMINATION ; THALAMUS
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25628
Collection健康与遗传心理学研究室
Affiliation1.Natl Taiwan Univ, Grad Inst Brain & Mind Sci, Coll Med, 1 Jen Rd Sect 1, Taipei 10051, Taiwan
2.Univ Oxford, Oxford Ctr Funct Magnet Resonance Imaging Brain, Oxford OX3 9DU, England
3.Univ Oxford, Nuffield Div Anaesthet, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Tseng, Ming-Tsung,Kong, Yazhuo,Eippert, Falk,et al. Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety[J]. JOURNAL OF NEUROSCIENCE,2017,37(49):11806-11817.
APA Tseng, Ming-Tsung,Kong, Yazhuo,Eippert, Falk,&Tracey, Irene.(2017).Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety.JOURNAL OF NEUROSCIENCE,37(49),11806-11817.
MLA Tseng, Ming-Tsung,et al."Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety".JOURNAL OF NEUROSCIENCE 37.49(2017):11806-11817.
Files in This Item:
File Name/Size DocType Version Access License
Determining the neur(1476KB)期刊论文出版稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Tseng, Ming-Tsung]'s Articles
[Kong, Yazhuo]'s Articles
[Eippert, Falk]'s Articles
Baidu academic
Similar articles in Baidu academic
[Tseng, Ming-Tsung]'s Articles
[Kong, Yazhuo]'s Articles
[Eippert, Falk]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tseng, Ming-Tsung]'s Articles
[Kong, Yazhuo]'s Articles
[Eippert, Falk]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Determining the neural substrate for encoding a memory of human pain and the influence of anxiety..pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.