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Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety
Tseng, Ming-Tsung1,2,3; Kong, Yazhuo2,3,4,5; Eippert, Falk2,3; Tracey, Irene2,3
2017-12-06
发表期刊JOURNAL OF NEUROSCIENCE
通讯作者邮箱mingtsungtseng@ntu.edu.tw.
ISSN0270-6474
文章类型Article
卷号37期号:49页码:11806-11817
摘要To convert a painful stimulus into a briefly maintainable construct when the painful stimulus is no longer accessible is essential to guide human behavior and avoid dangerous situations. Because of the aversive nature of pain, this encoding process might be influenced by emotional aspects and could thus vary across individuals, but we have yet to understand both the basic underlying neural mechanisms as well as potential interindividual differences. Using fMRI in combination with a delayed-discrimination task in healthy volunteers of both sexes, we discovered that brain regions involved in this working memory encoding process were dissociable according to whether the to-be-remembered stimulus was painful or not, with the medial thalamus and the rostral anterior cingulate cortex encoding painful and the primary somatosensory cortex encoding nonpainful stimuli. Encoding of painful stimuli furthermore significantly enhanced functional connectivity between the thalamus and medial prefrontal cortex (mPFC). With regards to emotional aspects influencing encoding processes, we observed that more anxious participants showed significant performance advantages when encoding painful stimuli. Importantly, only during the encoding of pain, the interindividual differences in anxiety were associated with the strength of coupling between medial thalamus and mPFC, which was furthermore related to activity in the amygdala. These results indicate not only that there is a distinct signature for the encoding of a painful experience in humans, but also that this encoding process involves a strong affective component.
关键词cognition encoding fMRI pain sensation vibration
DOI10.1523/JNEUROSCI.0750-17.2017
收录类别SCI ; SSCI
语种英语
项目资助者National Science Council(100-2917-I-564-028) ; Ministry of Science and Technology(103-2410-H-002-121-MY2) ; National Health Research Institutes of Taiwan(NHRI-EX106-10615NC) ; Marie Curie Fellowship(273805) ; National Institute for Health Research Oxford Biomedical Research Centre ; Medical Research Council of Great Britain and Northern Ireland ; Wellcome Trust (London, UK)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000418053700005
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]MEDIAL PREFRONTAL CORTEX ; PRIMARY SOMATOSENSORY CORTEX ; WORKING-MEMORY ; FUNCTIONAL CONNECTIVITY ; HUMAN BRAIN ; STIMULATION ; PERCEPTION ; ATTENTION ; DISCRIMINATION ; THALAMUS
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25628
专题健康与遗传心理学研究室
作者单位1.Natl Taiwan Univ, Grad Inst Brain & Mind Sci, Coll Med, 1 Jen Rd Sect 1, Taipei 10051, Taiwan
2.Univ Oxford, Oxford Ctr Funct Magnet Resonance Imaging Brain, Oxford OX3 9DU, England
3.Univ Oxford, Nuffield Div Anaesthet, Nuffield Dept Clin Neurosci, Oxford OX3 9DU, England
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
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GB/T 7714
Tseng, Ming-Tsung,Kong, Yazhuo,Eippert, Falk,et al. Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety[J]. JOURNAL OF NEUROSCIENCE,2017,37(49):11806-11817.
APA Tseng, Ming-Tsung,Kong, Yazhuo,Eippert, Falk,&Tracey, Irene.(2017).Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety.JOURNAL OF NEUROSCIENCE,37(49),11806-11817.
MLA Tseng, Ming-Tsung,et al."Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety".JOURNAL OF NEUROSCIENCE 37.49(2017):11806-11817.
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