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Effects of Hypothermia on S100B and Glial Fibrillary Acidic Protein in Asphyxia Rats After Cardiopulmonary Resuscitation
Xiaomin Lin1,2; Xinwen Bai1; Jianming Hao3; Zhang, YB
2014
发表期刊CELL BIOCHEMISTRY AND BIOPHYSICS
ISSN1085-9195
文章类型article
卷号71期号:1页码:401-404
摘要

The aim of the study was to investigate the effects of hypothermia on S100B and glial fibrillary acidic protein (GFAP) in serum and hippocampus CA1 area in asphyxiated rats after cardiopulmonary resuscitation (CPR). A total of 100 SD rats were designated into four groups: group A, sham operation group; group B, rats received conventional resuscitation; group C, rats received conventional resuscitation and hypothermia at cardiac arrest; group D, rats received conventional resuscitation and hypothermia at 30 min after restoration of spontaneous circulation (ROSC). Rats were then killed by cardiac arrest at 2 and 4 h after ROSC; brain tissue was taken to observe dynamic changes of S100B and GFAP in serum and hippocampus CA1 area. Following ROSC, S100B levels increased from 2 to 4 h in group B, C, and D. In addition, S100B in serum and hippocampus CA1 area was all significantly increased at different time points compared with group A (P < 0.05). Following ROSC, serum S100B level at 2 h in group C was significantly decreased compared with group B, but the difference was not statistically significant (P > 0.05). Moreover, S100B in serum at 4 h after ROSC was significantly decreased (P < 0.05), S100B in cortex was significantly decreased (P < 0.05). The expression of GFAP was also examined. GFAP level in hippocampus CA1 area was significantly decreased in group B, C, and D at 4 h after ROSC compared with group A (P < 0.05). S100B and GFAP were expressed in rat serum and hippocampus CA2 area at early stage after ROSC, which can be used as sensitive markers for brain injury diagnosis and prognosis prediction. Hypothermia is also shown to reduce brain injury after CPR.

关键词mental model mental model-based training complex system operator
收录类别其他
语种英语
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25646
专题社会与工程心理学研究室
通讯作者Zhang, YB
作者单位1.Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences
2.University of Chinese Academy of Sciences
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing
推荐引用方式
GB/T 7714
Xiaomin Lin,Xinwen Bai,Jianming Hao,et al. Effects of Hypothermia on S100B and Glial Fibrillary Acidic Protein in Asphyxia Rats After Cardiopulmonary Resuscitation[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2014,71(1):401-404.
APA Xiaomin Lin,Xinwen Bai,Jianming Hao,&Zhang, YB.(2014).Effects of Hypothermia on S100B and Glial Fibrillary Acidic Protein in Asphyxia Rats After Cardiopulmonary Resuscitation.CELL BIOCHEMISTRY AND BIOPHYSICS,71(1),401-404.
MLA Xiaomin Lin,et al."Effects of Hypothermia on S100B and Glial Fibrillary Acidic Protein in Asphyxia Rats After Cardiopulmonary Resuscitation".CELL BIOCHEMISTRY AND BIOPHYSICS 71.1(2014):401-404.
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