PSYCH OpenIR  > 社会与工程心理学研究室
Effects of Hypothermia on S100B and Glial Fibrillary Acidic Protein in Asphyxia Rats After Cardiopulmonary Resuscitation
Xiaomin Lin1,2; Xinwen Bai1; Jianming Hao3; Zhang, YB
2014
Source PublicationCELL BIOCHEMISTRY AND BIOPHYSICS
ISSN1085-9195
Subtypearticle
Volume71Issue:1Pages:401-404
Abstract

The aim of the study was to investigate the effects of hypothermia on S100B and glial fibrillary acidic protein (GFAP) in serum and hippocampus CA1 area in asphyxiated rats after cardiopulmonary resuscitation (CPR). A total of 100 SD rats were designated into four groups: group A, sham operation group; group B, rats received conventional resuscitation; group C, rats received conventional resuscitation and hypothermia at cardiac arrest; group D, rats received conventional resuscitation and hypothermia at 30 min after restoration of spontaneous circulation (ROSC). Rats were then killed by cardiac arrest at 2 and 4 h after ROSC; brain tissue was taken to observe dynamic changes of S100B and GFAP in serum and hippocampus CA1 area. Following ROSC, S100B levels increased from 2 to 4 h in group B, C, and D. In addition, S100B in serum and hippocampus CA1 area was all significantly increased at different time points compared with group A (P < 0.05). Following ROSC, serum S100B level at 2 h in group C was significantly decreased compared with group B, but the difference was not statistically significant (P > 0.05). Moreover, S100B in serum at 4 h after ROSC was significantly decreased (P < 0.05), S100B in cortex was significantly decreased (P < 0.05). The expression of GFAP was also examined. GFAP level in hippocampus CA1 area was significantly decreased in group B, C, and D at 4 h after ROSC compared with group A (P < 0.05). S100B and GFAP were expressed in rat serum and hippocampus CA2 area at early stage after ROSC, which can be used as sensitive markers for brain injury diagnosis and prognosis prediction. Hypothermia is also shown to reduce brain injury after CPR.

Keywordmental model mental model-based training complex system operator
Indexed By其他
Language英语
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25646
Collection社会与工程心理学研究室
Corresponding AuthorZhang, YB
Affiliation1.Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences
2.University of Chinese Academy of Sciences
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Xiaomin Lin,Xinwen Bai,Jianming Hao,et al. Effects of Hypothermia on S100B and Glial Fibrillary Acidic Protein in Asphyxia Rats After Cardiopulmonary Resuscitation[J]. CELL BIOCHEMISTRY AND BIOPHYSICS,2014,71(1):401-404.
APA Xiaomin Lin,Xinwen Bai,Jianming Hao,&Zhang, YB.(2014).Effects of Hypothermia on S100B and Glial Fibrillary Acidic Protein in Asphyxia Rats After Cardiopulmonary Resuscitation.CELL BIOCHEMISTRY AND BIOPHYSICS,71(1),401-404.
MLA Xiaomin Lin,et al."Effects of Hypothermia on S100B and Glial Fibrillary Acidic Protein in Asphyxia Rats After Cardiopulmonary Resuscitation".CELL BIOCHEMISTRY AND BIOPHYSICS 71.1(2014):401-404.
Files in This Item:
File Name/Size DocType Version Access License
Effects of Hypotherm(505KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xiaomin Lin]'s Articles
[Xinwen Bai]'s Articles
[Jianming Hao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xiaomin Lin]'s Articles
[Xinwen Bai]'s Articles
[Jianming Hao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xiaomin Lin]'s Articles
[Xinwen Bai]'s Articles
[Jianming Hao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Effects of Hypothermia on S100B and Glial Fibrillary Acidic Protein in Asphyxia Rats After Cardiopulmonary Resuscitation.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.