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GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice
Jie Liu1; Wei-Min Zhai2; Yuan-Xiao Yang3; Jin-Li Shi1; Qian-Tong Liu1; Guo-Lin Liu1; Nan Fang1; Jian Li1; Jian-You Guo4; J.-L. Shi; J.-Y. Guo
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The present study investigated the anxiolytic-like effects of spinosin, one of the major flavonoids in Ziziphi Spinosae Semen (ZSS), in experimental models of anxiety compared with a known anxiolytic, diazepam. Repeated treatment with spinosin (2.5 and 5 mg/kg/day, p.o.) significantly increased the percentage of entries into and time spent on the open arms of the elevated plus maze compared with the control group. In the light/dark box test, spinosin exerted an anxiolytic-like effect at 5 mg/kg. In the open-field test, 5 mg/kg spinosin increased the number of central entries. Spinosin did not affect spontaneous activity. The anxiolytic-like effects of spinosin in the elevated plus maze, light/dark box test, and open field test were blocked by the gamma-aminobutyric acid-A (GABA(A)) receptor antagonist flumazenil (3 mg/kg, i.p.) and 5-hydroxytryptamine-1A (5-HT1A) receptor antagonist WAY-100635 (1 mg/kg, i.p.). These results suggest that spinosin exerts anxiolytic-like effects, and its mechanism of action appears to be modulated by GABA(A) and 5-HT1A receptors. (C) 2014 Elsevier Inc. All rights reserved.

KeywordSpinosin Elevated plus maze Light/dark box Open field test GABA(A) receptor antagonist 5-HT1A receptor antagonist
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Document Type期刊论文
Corresponding AuthorJ.-L. Shi; J.-Y. Guo
Affiliation1.School of Chinese Materia Medica, Beijing University of Chinese Medicine, 6A Wangjing Central South Road, Chaoyang District, Beijing 100102, China
2.Standard of Chinese medicine, State Pharmacopoeia Commission, 11A Law of Southern China, Chongwen District, Beijing 100061, China
3.School of Pharmacy, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, PR China
4.Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 4A Datun Road, Chaoyang District, Beijing 100101, China
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GB/T 7714
Jie Liu,Wei-Min Zhai,Yuan-Xiao Yang,et al. GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2015,128(不详):41-49.
APA Jie Liu.,Wei-Min Zhai.,Yuan-Xiao Yang.,Jin-Li Shi.,Qian-Tong Liu.,...&J.-Y. Guo.(2015).GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,128(不详),41-49.
MLA Jie Liu,et al."GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 128.不详(2015):41-49.
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