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GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice
作者: Jie Liu1; Wei-Min Zhai2; Yuan-Xiao Yang3; Jin-Li Shi1; Qian-Tong Liu1; Guo-Lin Liu1; Nan Fang1; Jian Li1; Jian-You Guo4
通讯作者: J.-L. Shi ; J.-Y. Guo
通讯作者邮箱: shijl@vip.sina.com ; guojy@psych.ac.cn
关键词: Spinosin ; Elevated plus maze ; Light/dark box ; Open field test ; GABA(A) receptor antagonist ; 5-HT1A receptor antagonist
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN号: 0091-3057
出版日期: 2015
卷号: 128, 期号:不详, 页码:41-49
收录类别: 其他
英文摘要:

The present study investigated the anxiolytic-like effects of spinosin, one of the major flavonoids in Ziziphi Spinosae Semen (ZSS), in experimental models of anxiety compared with a known anxiolytic, diazepam. Repeated treatment with spinosin (2.5 and 5 mg/kg/day, p.o.) significantly increased the percentage of entries into and time spent on the open arms of the elevated plus maze compared with the control group. In the light/dark box test, spinosin exerted an anxiolytic-like effect at 5 mg/kg. In the open-field test, 5 mg/kg spinosin increased the number of central entries. Spinosin did not affect spontaneous activity. The anxiolytic-like effects of spinosin in the elevated plus maze, light/dark box test, and open field test were blocked by the gamma-aminobutyric acid-A (GABA(A)) receptor antagonist flumazenil (3 mg/kg, i.p.) and 5-hydroxytryptamine-1A (5-HT1A) receptor antagonist WAY-100635 (1 mg/kg, i.p.). These results suggest that spinosin exerts anxiolytic-like effects, and its mechanism of action appears to be modulated by GABA(A) and 5-HT1A receptors. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
DOI标识: 10.1016/j.pbb.2014.11.003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.psych.ac.cn/handle/311026/25674
Appears in Collections:中国科学院心理健康重点实验室_期刊论文

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作者单位: 1.School of Chinese Materia Medica, Beijing University of Chinese Medicine, 6A Wangjing Central South Road, Chaoyang District, Beijing 100102, China
2.Standard of Chinese medicine, State Pharmacopoeia Commission, 11A Law of Southern China, Chongwen District, Beijing 100061, China
3.School of Pharmacy, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, PR China
4.Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 4A Datun Road, Chaoyang District, Beijing 100101, China

Recommended Citation:
Jie Liu,Wei-Min Zhai,Yuan-Xiao Yang,et al. GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2015,128(不详):41-49.
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