Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing

doi:10.1093/schbul/sby036

	Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing
	Wang, Yi1 ; Li, Zhi 1,2; Liu, Wenhua 3; Wei, Xinhua 4; Jiang, Xinqing 4; Lui, S.S.Y.5; Suzanne, Howai So 6; Cheung, E.F.C.5; Debbane, M.7,8,9; Chan, R.C.K.1,2
第一作者	Wang, Yi
通讯作者邮箱	wangyi@psych.ac.cn
心理所单位排序	1
摘要	Background: Impairment in facial emotion perception is an important domain of social cognition deficits in schizophrenia. Although impaired facial emotion perception has been found in individuals with negative schizotypy (NS), little is known about the corresponding change in brain functional connectivity. Methods: Sixty-four participants were classified into a high NS group (n = 34) and a low NS group (n = 30) based on their total scores on the Chapman scales for physical and social anhedonia. All participants undertook a facial emotion discrimination functional imaging task that consisted of four emotional valences (angry, fear, happy, and neutral). For univariate analysis, the signal change at the bilateral amygdala was compared for each emotional contrast using SPSS (P < .05). For the functional connectivity analysis, we calculated the beta-series functional connectivity of the bilateral amygdala with the medial prefrontal cortex (mPFC) and compared the group differences in SPM12 (P < .05, small volume family-wise error correction). Results: No significant differences were found between the high and low NS groups in accuracy and reaction time in the facial emotion discrimination task. The high NS group showed reduced brain activations at the amygdala under fearful and neutral conditions. Reduced functional connectivity between the amygdala and the mPFC/dorsal anterior cingulate cortex under the happy and fearful conditions in the high NS group was also found. Conclusions: Our findings suggest that the individuals with high NS showed altered brain activity and functional connectivity at the amygdala during facial emotion processing and provide new evidence for understanding social cognition deficits in at-risk individuals.
关键词	facial emotion discrimination functional connectivity negative schizotypy amygdala mPFC
	2018
语种	英语
DOI	10.1093/schbul/sby036
发表期刊	Schizophrenia Bulletin
ISSN	0586-7614
卷号	44 期号:Suppl2 页码:S491-S500
期刊论文类型	实证研究
URL	查看原文
收录类别	SCI ; SSCI
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000448172600005
WOS分区	Q1
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/25686
专题	中国科学院心理健康重点实验室健康与遗传心理学研究室
作者单位	1.Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China; 2.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China; 3.Faculty of Health Management, Guangzhou Medical University, Guangzhou, China; 4.Department of Radiology, Guangzhou First People’s Hospital, Guangzhou, China; 5.Castle Peak Hospital, Hong Kong Special Administrative Region, China; 6.Department of Psychology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; 7.Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; 8.Developmental NeuroImaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland; 9.Research Department of Clinical, Educational and Health Psychology, University College London, London, UK
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Wang, Yi,Li, Zhi,Liu, Wenhua,et al. Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing[J]. Schizophrenia Bulletin,2018,44(Suppl2):S491-S500 .
APA	Wang, Yi.,Li, Zhi.,Liu, Wenhua.,Wei, Xinhua.,Jiang, Xinqing.,...&Chan, R.C.K..(2018).Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing.Schizophrenia Bulletin,44(Suppl2),S491-S500 .
MLA	Wang, Yi,et al."Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing".Schizophrenia Bulletin 44.Suppl2(2018):S491-S500 .

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