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Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing
Wang, Yi(王毅); Li, Zhi; Liu, Wenhua; Jiang, Xinqing; Lui, S.S.Y.; Cheung, E. F. C.; Debbane, M.; Chan, R. C. K.; Wang Y(王毅)
第一作者王毅
2018
发表期刊Schizophrenia Bulletin
通讯作者邮箱wangyi@psych.ac.cn
期号sby036页码:1-10
Q分类Q1
产权排序1
摘要

Background: Impairment in facial emotion perception is an important domain of social cognition deficits in schizophrenia. Although impaired facial emotion perception has been found in individuals with negative schizotypy (NS),  little is known about the corresponding change in brain functional connectivity.

Methods: Sixty-four participants were classified into a high NS group (n = 34) and a low NS group (n = 30) based on their total scores on the Chapman scales for physical and social anhedonia. All participants undertook a facial emotion discrimination functional imaging task that consisted of four emotional valences (angry, fear, happy, and neutral). For univariate analysis, the signal change at the bilateral amygdala was compared for each emotional contrast using SPSS (P < .05). For the functional connectivity analysis, we calculated the beta-series functional connectivity of the bilateral amygdala with the medial prefrontal cortex (mPFC) and compared the group differences in SPM12 (P < .05, small volume family-wise error correction).

Results: No significant differences were found between the high and low NS groups in accuracy and reaction time in the facial emotion discrimination task. The high NS group showed reduced brain activations at the amygdala under fearful and neutral conditions. Reduced functional connectivity between the amygdala and the mPFC/dorsal anterior cingulate cortex under the happy and fearful conditions in the high NS group was also found.

Conclusions: Our findings suggest that the individuals with high NS showed altered brain activity and functional connectivity at the amygdala during facial emotion processing and provide new evidence for understanding social cognition deficits in at-risk individuals.

关键词facial emotion discrimination functional connectivity negative schizotypy amygdala mPFC
DOI10.1093/schbul/sby036
收录类别SCI ; SSCI
语种英语
WOS记录号WOS:000448172600005
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25686
专题中国科学院心理健康重点实验室
健康与遗传心理学研究室
通讯作者Wang Y(王毅)
作者单位1.Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China
2.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
3.Faculty of Health Management, Guangzhou Medical University, Guangzhou, China
4.Department of Radiology, Guangzhou First People’s Hospital, Guangzhou, China
5.Castle Peak Hospital, Hong Kong Special Administrative Region, China
6.Department of Psychology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
7.Developmental Clinical Psychology Research Unit, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland
8.Developmental NeuroImaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland
9.Research Department of Clinical, Educational and Health Psychology, University College London, London, UK
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GB/T 7714
Wang, Yi,Li, Zhi,Liu, Wenhua,et al. Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing[J]. Schizophrenia Bulletin,2018(sby036):1-10.
APA Wang, Yi.,Li, Zhi.,Liu, Wenhua.,Jiang, Xinqing.,Lui, S.S.Y..,...&王毅.(2018).Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing.Schizophrenia Bulletin(sby036),1-10.
MLA Wang, Yi,et al."Negative Schizotypy and Altered Functional Connectivity during Facial Emotion Processing".Schizophrenia Bulletin .sby036(2018):1-10.
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