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Olfactory identification deficit and its relationship with hedonic traits in patients with first-episode schizophrenia and individuals with schizotypy
Zou, Lai-quan1,2,3; Zhou, Han-yu2,3; Lui, Simon S. Y.2,4; Wang, Yi2; Wang, Ya2; Gan, Jun5,6; Zhu, Xiong-zhao5,6; Cheung, Eric F. C.4; Chan, Raymond C. K.2,3; Raymond C.K. Chan
First AuthorLai-quan Zou
2018-04-20
Source PublicationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
SubtypeArticle
Volume83Issue:83Pages:137-141
QuartileQ1
Contribution Rank2
Abstract

Objective
Olfactory identification impairments have been consistently found in schizophrenia patients. However, few previous studies have investigated this in first-episode patients. There are also inconsistent findings regarding olfactory identification ability in psychometrically-defined schizotypy individuals. In this study, we directly compared the olfactory identification ability of first-episode schizophrenia patients with schizotypy individuals. The relationship between olfactory identification impairments and hedonic traits was also examined.

Methods
Thirty-five first-episode schizophrenia patients, 40 schizotypy individuals as defined by the Chapman's Anhedonia Scales and 40 demographically matched controls were recruited. The University of Pennsylvania Smell Identification Test was administered. Hedonic capacity was assessed using the Temporal Experience of Pleasure Scale (TEPS).

Results
The results showed that both the schizophrenia and schizotypy groups showed poorer olfactory identification ability than controls, and the impairment was significantly correlated with reduced pleasure experiences.

Conclusion
Our findings support olfactory identification impairment as a trait marker for schizophrenia.

; Objective: Olfactory identification impairments have been consistently found in schizophrenia patients. However, few previous studies have investigated this in first-episode patients. There are also inconsistent findings regarding olfactory identification ability in psychometrically-defined schizotypy individuals. In this study, we directly compared the olfactory identification ability of first-episode schizophrenia patients with schizotypy individuals. The relationship between olfactory identification impairments and hedonic traits was also examined.
KeywordSchizophrenia Social anhedonia Olfactory identification
DOI10.1016/j.pnpbp.2018.01.014
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Key Research and Development Programme(2016YFC0906402) ; National Natural Science Foundation of China(81571317 ; Beijing Municipal Science & Technology Commission(Z161100000216138) ; Beijing Training Project for the Leading Talents in Science and Technology(Z151100000315020) ; Natural Science Foundation of Guangdong Province, China(2017A030310069) ; 31700963)
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000424703700016
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordPSYCHOSIS ; PLEASURE ; SCALE ; EXPERIENCE ; ANHEDONIA ; SYMPTOMS ; SPECTRUM ; SAMPLE
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25688
Collection中国科学院心理健康重点实验室
健康与遗传心理学研究室
Corresponding AuthorRaymond C.K. Chan
Affiliation1.Southern Med Univ, Sch Publ Hlth, Dept Psychol, Guangdong Prov Key Lab Trop Dis Res, Guangzhou, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
5.Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha, Hunan, Peoples R China
6.Cent S Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Zou, Lai-quan,Zhou, Han-yu,Lui, Simon S. Y.,et al. Olfactory identification deficit and its relationship with hedonic traits in patients with first-episode schizophrenia and individuals with schizotypy[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2018,83(83):137-141.
APA Zou, Lai-quan.,Zhou, Han-yu.,Lui, Simon S. Y..,Wang, Yi.,Wang, Ya.,...&Raymond C.K. Chan.(2018).Olfactory identification deficit and its relationship with hedonic traits in patients with first-episode schizophrenia and individuals with schizotypy.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,83(83),137-141.
MLA Zou, Lai-quan,et al."Olfactory identification deficit and its relationship with hedonic traits in patients with first-episode schizophrenia and individuals with schizotypy".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 83.83(2018):137-141.
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