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Olfactory identification deficit and its relationship with hedonic traits in patients with first-episode schizophrenia and individuals with schizotypy
Zou, Lai-quan1,2,3; Zhou, Han-yu2,3; Lui, Simon S. Y.2,4; Wang, Yi2; Wang, Ya2; Gan, Jun5,6; Zhu, Xiong-zhao5,6; Cheung, Eric F. C.4; Chan, Raymond C. K.2,3; Raymond C.K. Chan
第一作者Lai-quan Zou
2018-04-20
发表期刊PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
文章类型Article
卷号83期号:83页码:137-141
Q分类Q1
产权排序2
摘要

Objective
Olfactory identification impairments have been consistently found in schizophrenia patients. However, few previous studies have investigated this in first-episode patients. There are also inconsistent findings regarding olfactory identification ability in psychometrically-defined schizotypy individuals. In this study, we directly compared the olfactory identification ability of first-episode schizophrenia patients with schizotypy individuals. The relationship between olfactory identification impairments and hedonic traits was also examined.

Methods
Thirty-five first-episode schizophrenia patients, 40 schizotypy individuals as defined by the Chapman's Anhedonia Scales and 40 demographically matched controls were recruited. The University of Pennsylvania Smell Identification Test was administered. Hedonic capacity was assessed using the Temporal Experience of Pleasure Scale (TEPS).

Results
The results showed that both the schizophrenia and schizotypy groups showed poorer olfactory identification ability than controls, and the impairment was significantly correlated with reduced pleasure experiences.

Conclusion
Our findings support olfactory identification impairment as a trait marker for schizophrenia.

; Objective: Olfactory identification impairments have been consistently found in schizophrenia patients. However, few previous studies have investigated this in first-episode patients. There are also inconsistent findings regarding olfactory identification ability in psychometrically-defined schizotypy individuals. In this study, we directly compared the olfactory identification ability of first-episode schizophrenia patients with schizotypy individuals. The relationship between olfactory identification impairments and hedonic traits was also examined.
关键词Schizophrenia Social anhedonia Olfactory identification
DOI10.1016/j.pnpbp.2018.01.014
收录类别SCI ; SSCI
语种英语
项目资助者National Key Research and Development Programme(2016YFC0906402) ; National Natural Science Foundation of China(81571317 ; Beijing Municipal Science & Technology Commission(Z161100000216138) ; Beijing Training Project for the Leading Talents in Science and Technology(Z151100000315020) ; Natural Science Foundation of Guangdong Province, China(2017A030310069) ; 31700963)
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000424703700016
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]PSYCHOSIS ; PLEASURE ; SCALE ; EXPERIENCE ; ANHEDONIA ; SYMPTOMS ; SPECTRUM ; SAMPLE
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25688
专题中国科学院心理健康重点实验室
健康与遗传心理学研究室
通讯作者Raymond C.K. Chan
作者单位1.Southern Med Univ, Sch Publ Hlth, Dept Psychol, Guangdong Prov Key Lab Trop Dis Res, Guangzhou, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
5.Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha, Hunan, Peoples R China
6.Cent S Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China
推荐引用方式
GB/T 7714
Zou, Lai-quan,Zhou, Han-yu,Lui, Simon S. Y.,et al. Olfactory identification deficit and its relationship with hedonic traits in patients with first-episode schizophrenia and individuals with schizotypy[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2018,83(83):137-141.
APA Zou, Lai-quan.,Zhou, Han-yu.,Lui, Simon S. Y..,Wang, Yi.,Wang, Ya.,...&Raymond C.K. Chan.(2018).Olfactory identification deficit and its relationship with hedonic traits in patients with first-episode schizophrenia and individuals with schizotypy.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,83(83),137-141.
MLA Zou, Lai-quan,et al."Olfactory identification deficit and its relationship with hedonic traits in patients with first-episode schizophrenia and individuals with schizotypy".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 83.83(2018):137-141.
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