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Intrinsic spontaneous brain activity predicts individual variability in associative memory in older adults
Zheng Zhiwei1,2; Li Rui1,2,3; Xiao Fengqiu4; He Rongqiao5; Zhang Shouzi6; Li Juan1,2,3,5
第一作者Zheng Zhiwei
2018
发表期刊Psych Journal
通讯作者邮箱lijuan@psych.ac.cn
文章类型Article
期号2页码:1-15
产权排序1
摘要

Older adults demonstrate notable individual differences in associative memory. Here, resting-state functional magnetic resonance imaging (rsfMRI) was used to investigate whether intrinsic brain activity at rest could predict individual differences in associative memory among cognitively healthy older adults. Regional amplitude of low-frequency fluctuations (ALFF) analysis and a correlation-based resting-state functional connectivity (RSFC) approach were used to analyze data acquired from 102 cognitively normal elderly who completed the paired-associative learning test (PALT) and underwent fMRI scans. Participants were divided into two groups based on the retrospective self-reports on whether or not they utilized encoding strategies during the PALT. The behavioral results revealed better associative memory performance in the participants who reported utilizing memory strategies compared with participants who reported not doing so. The fMRI results showed that higher associative memory performance was associated with greater functional connectivity between the right superior frontal gyrus and the right posterior cerebellum lobe in the strategy group. The regional ALFF values in the right superior frontal gyrus were linked to associative memory performance in the no-strategy group. These findings suggest that the regional spontaneous fluctuations and functional connectivity during rest may subserve the individual differences in the associative memory in older adults, and that this is modulated by self-initiated memory strategy use.

关键词associative memory elderly individual differences memory strategies resting-state functional magnetic resonance imaging (rsfMRI)
DOI10.1002/pchj.212
收录类别SSCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25691
专题健康与遗传心理学研究室
通讯作者Li Juan
作者单位1.Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
2.Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
3.Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
4.China National Children’s Center, Beijing, China
5.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
6.Beijing Geriatric Hospital, Beijing, China
推荐引用方式
GB/T 7714
Zheng Zhiwei,Li Rui,Xiao Fengqiu,et al. Intrinsic spontaneous brain activity predicts individual variability in associative memory in older adults[J]. Psych Journal,2018(2):1-15.
APA Zheng Zhiwei,Li Rui,Xiao Fengqiu,He Rongqiao,Zhang Shouzi,&Li Juan.(2018).Intrinsic spontaneous brain activity predicts individual variability in associative memory in older adults.Psych Journal(2),1-15.
MLA Zheng Zhiwei,et al."Intrinsic spontaneous brain activity predicts individual variability in associative memory in older adults".Psych Journal .2(2018):1-15.
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