The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall

doi:10.3389/fnagi.2018.00006

PSYCH OpenIR > 健康与遗传心理学研究室

	The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall
	Huo, Lijuan 1,2; Li, Rui1,2 ; Wang, Pengyun1,2 ; Zheng, Zhiwei1,2 ; Li, Juan1,2 ; Li Juan
第一作者	Huo Lijuan
通讯作者邮箱	lijuan@psych.ac.cn
心理所单位排序	1
摘要	While the neural correlates of age-related decline in episodic memory have been the subject of much interest, the spontaneous functional architecture of the brain for various memory processes in elderly adults, such as immediate recall (IR) and delayed recall (DR), remains unclear. The present study thus examined the neural correlates of age-related decline of various memory processes. A total of 66 cognitively normal older adults (aged 60-80 years) participated in this study. Memory processes were measured using the Auditory Verbal Learning Test as well as resting-state brain images, which were analyzed using both regional homogeneity (ReHo) and correlation-based functional connectivity (FC) approaches. We found that both IR and DR were significantly correlated with the ReHo of these critical regions, all within the default mode network (DMN), including the parahippocampal gyrus, posterior cingulate cortex/precuneus, inferior parietal lobule, and medial prefrontal cortex. In addition, DR was also related to the FC between these DMN regions. These results suggest that the DMN plays different roles in memory retrieval across different retention intervals, and connections between the DMN regions contribute to memory consolidation of past events in healthy older people.
关键词	immediate recall delayed recall default mode network functional connectivity regional homogeneity
	2018-01-24
语种	英语
DOI	10.3389/fnagi.2018.00006
发表期刊	FRONTIERS IN AGING NEUROSCIENCE
ISSN	1663-4365
卷号	10 期号:6 页码:1-10
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	RESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; REGIONAL HOMOGENEITY ; AUDITORY-CORTEX ; IMPAIRMENT ; SPEECH ; MRI ; CONSOLIDATION ; HIPPOCAMPAL
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS记录号	WOS:000423187800001
Q分类	Q1
资助机构	National Natural Science Foundation of China(31671157 ; Beijing Municipal Science & Technology Commission(Z171100000117006) ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program(TSS-2015-06) ; CAS Key Laboratory of Mental Health, Institute of Psychology(KLMH2014ZK02 ; 31470998 ; KLMH2014ZG03) ; 61673374 ; 31271108 ; 31200847)
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/25694
专题	健康与遗传心理学研究室
通讯作者	Li Juan
作者单位	1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Huo, Lijuan,Li, Rui,Wang, Pengyun,et al. The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10(6):1-10.
APA	Huo, Lijuan,Li, Rui,Wang, Pengyun,Zheng, Zhiwei,Li, Juan,&Li Juan.(2018).The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall.FRONTIERS IN AGING NEUROSCIENCE,10(6),1-10.
MLA	Huo, Lijuan,et al."The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall".FRONTIERS IN AGING NEUROSCIENCE 10.6(2018):1-10.

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