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The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall
Huo, Lijuan1,2; Li, Rui1,2; Wang, Pengyun1,2; Zheng, Zhiwei1,2; Li, Juan1,2; Li Juan
First AuthorHuo Lijuan
2018-01-24
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
Correspondent Emaillijuan@psych.ac.cn
ISSN1663-4365
SubtypeArticle
Volume10Issue:6Pages:1-10
QuartileQ1
Contribution Rank1
AbstractWhile the neural correlates of age-related decline in episodic memory have been the subject of much interest, the spontaneous functional architecture of the brain for various memory processes in elderly adults, such as immediate recall (IR) and delayed recall (DR), remains unclear. The present study thus examined the neural correlates of age-related decline of various memory processes. A total of 66 cognitively normal older adults (aged 60-80 years) participated in this study. Memory processes were measured using the Auditory Verbal Learning Test as well as resting-state brain images, which were analyzed using both regional homogeneity (ReHo) and correlation-based functional connectivity (FC) approaches. We found that both IR and DR were significantly correlated with the ReHo of these critical regions, all within the default mode network (DMN), including the parahippocampal gyrus, posterior cingulate cortex/precuneus, inferior parietal lobule, and medial prefrontal cortex. In addition, DR was also related to the FC between these DMN regions. These results suggest that the DMN plays different roles in memory retrieval across different retention intervals, and connections between the DMN regions contribute to memory consolidation of past events in healthy older people.
Keywordimmediate recall delayed recall default mode network functional connectivity regional homogeneity
DOI10.3389/fnagi.2018.00006
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31671157 ; Beijing Municipal Science & Technology Commission(Z171100000117006) ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program(TSS-2015-06) ; CAS Key Laboratory of Mental Health, Institute of Psychology(KLMH2014ZK02 ; 31470998 ; KLMH2014ZG03) ; 61673374 ; 31271108 ; 31200847)
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000423187800001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordRESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; REGIONAL HOMOGENEITY ; AUDITORY-CORTEX ; IMPAIRMENT ; SPEECH ; MRI ; CONSOLIDATION ; HIPPOCAMPAL
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25694
Collection健康与遗传心理学研究室
Corresponding AuthorLi Juan
Affiliation1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Huo, Lijuan,Li, Rui,Wang, Pengyun,et al. The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10(6):1-10.
APA Huo, Lijuan,Li, Rui,Wang, Pengyun,Zheng, Zhiwei,Li, Juan,&Li Juan.(2018).The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall.FRONTIERS IN AGING NEUROSCIENCE,10(6),1-10.
MLA Huo, Lijuan,et al."The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall".FRONTIERS IN AGING NEUROSCIENCE 10.6(2018):1-10.
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