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The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall
Huo, Lijuan1,2; Li, Rui1,2; Wang, Pengyun1,2; Zheng, Zhiwei1,2; Li, Juan1,2; Li Juan
第一作者Huo Lijuan
2018-01-24
发表期刊FRONTIERS IN AGING NEUROSCIENCE
通讯作者邮箱lijuan@psych.ac.cn
ISSN1663-4365
文章类型Article
卷号10期号:6页码:1-10
Q分类Q1
产权排序1
摘要While the neural correlates of age-related decline in episodic memory have been the subject of much interest, the spontaneous functional architecture of the brain for various memory processes in elderly adults, such as immediate recall (IR) and delayed recall (DR), remains unclear. The present study thus examined the neural correlates of age-related decline of various memory processes. A total of 66 cognitively normal older adults (aged 60-80 years) participated in this study. Memory processes were measured using the Auditory Verbal Learning Test as well as resting-state brain images, which were analyzed using both regional homogeneity (ReHo) and correlation-based functional connectivity (FC) approaches. We found that both IR and DR were significantly correlated with the ReHo of these critical regions, all within the default mode network (DMN), including the parahippocampal gyrus, posterior cingulate cortex/precuneus, inferior parietal lobule, and medial prefrontal cortex. In addition, DR was also related to the FC between these DMN regions. These results suggest that the DMN plays different roles in memory retrieval across different retention intervals, and connections between the DMN regions contribute to memory consolidation of past events in healthy older people.
关键词immediate recall delayed recall default mode network functional connectivity regional homogeneity
DOI10.3389/fnagi.2018.00006
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(31671157 ; Beijing Municipal Science & Technology Commission(Z171100000117006) ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program(TSS-2015-06) ; CAS Key Laboratory of Mental Health, Institute of Psychology(KLMH2014ZK02 ; 31470998 ; KLMH2014ZG03) ; 61673374 ; 31271108 ; 31200847)
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目Geriatrics & Gerontology ; Neurosciences
WOS记录号WOS:000423187800001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]RESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; REGIONAL HOMOGENEITY ; AUDITORY-CORTEX ; IMPAIRMENT ; SPEECH ; MRI ; CONSOLIDATION ; HIPPOCAMPAL
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25694
专题健康与遗传心理学研究室
通讯作者Li Juan
作者单位1.Chinese Acad Sci, Inst Psychol, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Huo, Lijuan,Li, Rui,Wang, Pengyun,et al. The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10(6):1-10.
APA Huo, Lijuan,Li, Rui,Wang, Pengyun,Zheng, Zhiwei,Li, Juan,&Li Juan.(2018).The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall.FRONTIERS IN AGING NEUROSCIENCE,10(6),1-10.
MLA Huo, Lijuan,et al."The Default Mode Network Supports Episodic Memory in Cognitively Unimpaired Elderly Individuals: Different Contributions to Immediate Recall and Delayed Recall".FRONTIERS IN AGING NEUROSCIENCE 10.6(2018):1-10.
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