Cortical Inhibition Related to Aging and Mental Disorders

doi:10.16476/j.pibb.2017.0391

	Cortical Inhibition Related to Aging and Mental Disorders
	Chen Wei-Ying 2,3; Li Sheng-Guang1,2 ; Zhang Tao1,2,3
第一作者	陈为迎 ; 李胜光
通讯作者邮箱	taozhang@psych.ac.cn
心理所单位排序	2
摘要	The neural network of our brain processes all kinds of information through excitatory and inhibitory synapses. Although there are less inhibitory neurons in the brain, they are extremely important in regulating information processing and neuronal plasticity. Further more, various of brain dysfunctions are related to the disfunction of inhibitory system. Inter-cortical inhibition, which includes feedforward and feedback projections, mediates the inhibitory effects between different brain areas. Intra-cortical inhibition, or mutual inhibition, mediates inhibitory interactions between neurons nearby but with different preferences. In this review, we introduced the behavioral performance of two kinds of inbitiory mechanisms, using center-surround suppression and motion repulsion paradigm as examples. Then we related the changes of cortical inhibition to aging and two typical mental disorders.
其他摘要	脑神经网络信息加工的实现方式主要依赖于兴奋性和抑制性突触连接．脑内抑制性神经元数量较少，但在信息加工和神经可塑性等方面作用极其重要，而且抑制系统失常与多种脑功能障碍有关联．脑内抑制性神经环路可粗略分为皮层内和皮层间(包括前馈和反馈)两种，分别介导同一脑区内和不同脑区间的抑制作用．本文先围绕中心- 外周抑制和运动方向互斥介绍了皮层间、皮层内抑制的行为表现和作用机制，然后以老化和精神疾病为例综述了脑功能障碍与视觉系统皮层抑制功能变化间的联系，希望能对相关研究工作有所助益．
关键词	inter-cortical inhibition intra-cortical inhibition center-surround suppression motion repulsion brain dysfunction
	2018-04-01
语种	英语
DOI	10.16476/j.pibb.2017.0391
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN	1000-3282
卷号	45 期号:4 页码:401-408
期刊论文类型	Article
收录类别	SCI
WOS关键词	CENTER-SURROUND ANTAGONISM ; CLASSICAL RECEPTIVE-FIELD ; VISUAL-CORTEX ; BIPOLAR DISORDER ; MOTION PERCEPTION ; DIRECTION REPULSION ; GABA NEURONS ; SCHIZOPHRENIA ; NETWORK ; SUPPRESSION
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000430898100002
资助机构	National Natural Science Foundation of China(31271175)
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/25696
专题	脑与认知科学国家重点实验室认知与发展心理学研究室
通讯作者	Zhang Tao
作者单位	1.State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理研究所
通讯作者单位	脑与认知科学国家重点实验室; 中国科学院心理研究所
推荐引用方式 GB/T 7714	Chen Wei-Ying,Li Sheng-Guang,Zhang Tao. Cortical Inhibition Related to Aging and Mental Disorders[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2018,45(4):401-408.
APA	Chen Wei-Ying,Li Sheng-Guang,&Zhang Tao.(2018).Cortical Inhibition Related to Aging and Mental Disorders.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,45(4),401-408.
MLA	Chen Wei-Ying,et al."Cortical Inhibition Related to Aging and Mental Disorders".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 45.4(2018):401-408.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
老化和精神疾病引起的皮层抑制功能变化_陈（437KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	请求全文