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Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression
Jiang, Lili1,2,3; Sui, Danyang1,2,4; Qiao, Kaini1,2,4; Dong, Hao-Ming1,2,4; Chen, Luonan5; Han, Ying6,7,8,9,10,11; Jiang Lili; Han Ying
First AuthorJiang Lili
2018-01-22
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
SubtypeArticle
Volume8Issue:1Pages:doi: 10. 1038/s41598-018-19674-7
QuartileQ1
Contribution Rank1
AbstractThe progression of Alzheimer's Disease (AD) has been proposed to comprise three stages, subjective cognitive decline (SCD), mild cognitive impairment (MCI), and AD. Was brain dynamics across the three stages smooth? Was there a critical transition? How could we characterize and study functional criticality of human brain? Based on dynamical characteristics of critical transition from nonlinear dynamics, we proposed a vertex-wise Index of Functional Criticality (vIFC) of fMRI time series in this study. Using 42 SCD, 67 amnestic MCI (aMCI), 34 AD patients as well as their age-, sex-, years of education-matched 54 NC, our new method vIFC successfully detected significant patient-normal differences for SCD and aMCI, as well as significant negative correlates of vIFC in the right middle temporal gyrus with total scores of Montreal Cognitive Assessment (MoCA) in SCD. In comparison, standard deviation of fMRI time series only detected significant differences between AD patients and normal controls. As an index of functional criticality of human brain derived from nonlinear dynamics, vIFC could serve as a sensitive neuroimaging marker for future studies; considering much more vIFC impairments in aMCI compared to SCD and AD, our study indicated aMCI as a critical stage across AD progression.
DOI10.1038/s41598-018-19674-7
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(11674388 ; Startup Foundation for Young Talents of the Institute of Psychology(Y1CX222005) ; National Key Basic Research and Development (973) Program(2015CB351702) ; National Key Research and Development Program of China(2016YFC1306300) ; Beijing Nature Science Foundation(7161009) ; Beijing Municipal Science & Technology Commission(Z161100002616020) ; Capital Medical University(16JL-L08) ; 11204369 ; 81471740 ; 31371007 ; 81430037 ; 61633018)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000422912100007
WOS HeadingsScience & Technology
WOS KeywordMILD COGNITIVE IMPAIRMENT ; SUBJECTIVE MEMORY IMPAIRMENT ; SURFACE-BASED ANALYSIS ; DECLINE ; BIOMARKERS ; CORTEX ; CONNECTIVITY ; TASK
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25700
Collection中国科学院行为科学重点实验室
Corresponding AuthorJiang Lili; Han Ying
Affiliation1.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Lifespan Connect & Behav Team, Beijing 100101, Peoples R China
3.Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA
4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Biol Sci, Innovat Ctr Cell Signaling Network, Inst Biochem & Cell Biol,Key Lab Syst Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China
6.Capital Med Univ, XuanWu Hosp, Dept Neurol, Beijing 100053, Peoples R China
7.Ctr Alzheimers Dis, Beijing 100053, Peoples R China
8.Inst Brain Disorders, Beijing 100053, Peoples R China
9.Beijing Inst Geriatr, Beijing 100053, Peoples R China
10.Natl Clin Res Ctr Geriatr Disorders, Beijing, Peoples R China
11.PKU Care Rehabil Hosp, Beijing 100053, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Lili,Sui, Danyang,Qiao, Kaini,et al. Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression[J]. SCIENTIFIC REPORTS,2018,8(1):doi: 10. 1038/s41598-018-19674-7.
APA Jiang, Lili.,Sui, Danyang.,Qiao, Kaini.,Dong, Hao-Ming.,Chen, Luonan.,...&Han Ying.(2018).Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression.SCIENTIFIC REPORTS,8(1),doi: 10. 1038/s41598-018-19674-7.
MLA Jiang, Lili,et al."Impaired Functional Criticality of Human Brain during Alzheimer's Disease Progression".SCIENTIFIC REPORTS 8.1(2018):doi: 10. 1038/s41598-018-19674-7.
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