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The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects
Wei, Hua1,2,3; Zhou, Lili1,2; Zhang, Huijuan1,2,3; Chen, Jie4; Lu, Xuejing1,2; Hu, Li1,2,3,4; Jie Chen; Xuejing Lu
第一作者Hua Wei
2018
发表期刊PAIN RESEARCH & MANAGEMENT
通讯作者邮箱xlxchen@163.com ; luxj@psych.ac.cn
ISSN1203-6765
文章类型Article
期号0页码:0
Q分类Q3
产权排序1
摘要Nondeceptive placebo has demonstrated its efficiency in clinical practice. Although the underlying mechanisms are still unclear, nondeceptive placebo effect and nondeceptive nocebo effect may be mediated by expectation. To examine the extent to which expectation influences these effects, the present study compared nondeceptive placebo and nocebo effects with different expectation levels. Seventy-two healthy female participants underwent a standard conditioning procedure to establish placebo and nocebo effects. Sequentially, participants were randomized to one of the four experimental groups-baseline (BL), no expectation intervention (NoEI), expectation increasing (EI), and expectation decreasing (ED) groups, to receive either no intervention or interventions through different verbal suggestions that modulated their expectation. Placebo and nocebo effects were established in all four groups after the conditioning phase. However, after disclosing the placebo and nocebo, the analgesic and the hyperalgesic effects only persisted in the EI group, when compared with the BL group. Our results provide evidence highlighting the critical role of increased expectation in nondeceptive placebo and nocebo effects. The finding suggests that open-label placebo or nocebo per se might be insufficient to induce strong analgesic or hyperalgesic response and sheds insights into administrating open-label placebo and avoiding open-label nocebo in clinical practice.
DOI10.1155/2018/8459429
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31471082 ; Chongqing Research Program of Basic Research and Frontier Technology(cstc2015jcyjBX0050) ; Scientific Foundation Project of Institute of Psychology, Chinese Academy of Sciences(Y6CX021008 ; Cognition and Human Behavior Key Laboratory of Hunan Province, Hunan Normal University(CBL201605) ; 31671141 ; Y6CX281007) ; 31701000 ; 31771240)
项目简介The work was supported by the National Natural Science Foundation of China (nos 31471082, 31671141, 31701000, and 31771240), Chongqing Research Program of Basic Research and Frontier Technology (no. cstc2015jcyjBX0050), the Scientific Foundation Project of Institute of Psychology, Chinese Academy of Sciences (nos Y6CX021008 and Y6CX281007), and Cognition and Human Behavior Key Laboratory of Hunan Province, Hunan Normal University (CBL201605). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS研究方向Neurosciences & Neurology
WOS类目Clinical Neurology
WOS记录号WOS:000428908900001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]RANDOMIZED CONTROLLED-TRIAL ; IRRITABLE-BOWEL-SYNDROME ; INFORMED-CONSENT ; PAIN PERCEPTION ; BRAIN ACTIVITY ; ANALGESIA ; RESPONSES ; MECHANISMS ; EXPERIENCE ; ANXIETY
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25701
专题中国科学院心理健康重点实验室
通讯作者Jie Chen; Xuejing Lu
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
4.Hunan Normal Univ, Cognit & Human Behav Key Lab Hunan Prov, Changsha, Hunan, Peoples R China
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Wei, Hua,Zhou, Lili,Zhang, Huijuan,et al. The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects[J]. PAIN RESEARCH & MANAGEMENT,2018(0):0.
APA Wei, Hua.,Zhou, Lili.,Zhang, Huijuan.,Chen, Jie.,Lu, Xuejing.,...&Xuejing Lu.(2018).The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects.PAIN RESEARCH & MANAGEMENT(0),0.
MLA Wei, Hua,et al."The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects".PAIN RESEARCH & MANAGEMENT .0(2018):0.
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