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Differential muscarinic modulation of synaptic transmission in dorsal and ventral regions of the rat nucleus accumbens core
Jiang, Xiao1,3; Zhang, Jianjun1; Wang, Mengya2; Sui, Nan1
第一作者Jiang, Xiao ; Zhang, Jianjun
2014
发表期刊PHYSIOLOGICAL RESEARCH
通讯作者邮箱wangmy@wnmc.edu.cn ; suin@psych.ac.cn
ISSN0862-8408
卷号63期号:1页码:135-142
Q分类Q3
产权排序1
摘要

The nucleus accumbens (NAc) core is critical in the control of motivated behaviors. The muscarinic acetylcholine receptors (mAChRs) modulating the excitatory inputs into the NAc core have been reported to impact such behaviors. Recent studies suggest that ventral and dorsal regions of the NAc core seem to be innervated by distinct populations of glutamatergic projection neurons. To further examine mAChRs modulation of these glutamatergic inputs to the NAc core, we employed intracellular recordings in rat NAc coronal slice preparation to characterize: 1) the effects of muscarine, an mAChRs agonist, on membrane properties of the NAc core neurons; 2) depolarizing synaptic potentials (DPSP) elicited by ventral and dorsal focal electrical stimuli; and 3) paired-pulse response with paired-pulse stimulation. Here we report that the paired-pulse ratio (PPR) elicited by dorsal stimuli was greater than that elicited by ventral stimuli. Bath application of muscarine (1-30 mu M) decreased both ventral and dorsal DPSP in a concentration-dependent manner, with no effect on electrophysiological properties of NAc core neurons. Muscarine at 30 mu M also elicited larger depression of dorsal DPSP than ventral DPSP. Moreover, muscarine increased the PPR of both dorsal and ventral DPSP. These data indicate that the glutamatergic afferent fibers traversing the dorsal and ventral NAc are separate, and that differential decrease of distinct afferent excitatory neurotransmission onto NAc core neurons may be mediated by presynaptic mechanisms.

关键词Muscarine Nucleus accumbens Postsynaptic potentials Paired-pulse ratio In vitro
收录类别SCI
语种英语
WOS记录号WOS:000333406000014
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25711
专题中国科学院心理健康重点实验室
通讯作者Wang, Mengya; Sui, Nan
作者单位1.Chinese Acad Sci, Inst Psychol, Mental Hlth Key Lab, Beijing 100101, Peoples R China
2.Wannan Med Coll, Cell Electrophysiol Lab, Wuhu 241002, Anhui, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
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GB/T 7714
Jiang, Xiao,Zhang, Jianjun,Wang, Mengya,et al. Differential muscarinic modulation of synaptic transmission in dorsal and ventral regions of the rat nucleus accumbens core[J]. PHYSIOLOGICAL RESEARCH,2014,63(1):135-142.
APA Jiang, Xiao,Zhang, Jianjun,Wang, Mengya,&Sui, Nan.(2014).Differential muscarinic modulation of synaptic transmission in dorsal and ventral regions of the rat nucleus accumbens core.PHYSIOLOGICAL RESEARCH,63(1),135-142.
MLA Jiang, Xiao,et al."Differential muscarinic modulation of synaptic transmission in dorsal and ventral regions of the rat nucleus accumbens core".PHYSIOLOGICAL RESEARCH 63.1(2014):135-142.
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