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Differential muscarinic modulation of synaptic transmission in dorsal and ventral regions of the rat nucleus accumbens core
Jiang, Xiao1,3; Zhang, Jianjun1; Wang, Mengya2; Sui, Nan1
First AuthorJiang, Xiao ; Zhang, Jianjun
2014
Source PublicationPHYSIOLOGICAL RESEARCH
Correspondent Emailwangmy@wnmc.edu.cn ; suin@psych.ac.cn
ISSN0862-8408
Volume63Issue:1Pages:135-142
QuartileQ3
Contribution Rank1
Abstract

The nucleus accumbens (NAc) core is critical in the control of motivated behaviors. The muscarinic acetylcholine receptors (mAChRs) modulating the excitatory inputs into the NAc core have been reported to impact such behaviors. Recent studies suggest that ventral and dorsal regions of the NAc core seem to be innervated by distinct populations of glutamatergic projection neurons. To further examine mAChRs modulation of these glutamatergic inputs to the NAc core, we employed intracellular recordings in rat NAc coronal slice preparation to characterize: 1) the effects of muscarine, an mAChRs agonist, on membrane properties of the NAc core neurons; 2) depolarizing synaptic potentials (DPSP) elicited by ventral and dorsal focal electrical stimuli; and 3) paired-pulse response with paired-pulse stimulation. Here we report that the paired-pulse ratio (PPR) elicited by dorsal stimuli was greater than that elicited by ventral stimuli. Bath application of muscarine (1-30 mu M) decreased both ventral and dorsal DPSP in a concentration-dependent manner, with no effect on electrophysiological properties of NAc core neurons. Muscarine at 30 mu M also elicited larger depression of dorsal DPSP than ventral DPSP. Moreover, muscarine increased the PPR of both dorsal and ventral DPSP. These data indicate that the glutamatergic afferent fibers traversing the dorsal and ventral NAc are separate, and that differential decrease of distinct afferent excitatory neurotransmission onto NAc core neurons may be mediated by presynaptic mechanisms.

KeywordMuscarine Nucleus accumbens Postsynaptic potentials Paired-pulse ratio In vitro
Indexed BySCI
Language英语
WOS IDWOS:000333406000014
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25711
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Mengya; Sui, Nan
Affiliation1.Chinese Acad Sci, Inst Psychol, Mental Hlth Key Lab, Beijing 100101, Peoples R China
2.Wannan Med Coll, Cell Electrophysiol Lab, Wuhu 241002, Anhui, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Xiao,Zhang, Jianjun,Wang, Mengya,et al. Differential muscarinic modulation of synaptic transmission in dorsal and ventral regions of the rat nucleus accumbens core[J]. PHYSIOLOGICAL RESEARCH,2014,63(1):135-142.
APA Jiang, Xiao,Zhang, Jianjun,Wang, Mengya,&Sui, Nan.(2014).Differential muscarinic modulation of synaptic transmission in dorsal and ventral regions of the rat nucleus accumbens core.PHYSIOLOGICAL RESEARCH,63(1),135-142.
MLA Jiang, Xiao,et al."Differential muscarinic modulation of synaptic transmission in dorsal and ventral regions of the rat nucleus accumbens core".PHYSIOLOGICAL RESEARCH 63.1(2014):135-142.
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