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Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving
Li, Xuan1,2; Witonsky, Kailyn R.1; Lofaro, Olivia M.1; Surjono, Felicia1; Zhang, Jianjun1,3; Bossert, Jennifer M.1; Shaham, Yavin1
第一作者Li, Xuan
2018-02-28
发表期刊JOURNAL OF NEUROSCIENCE
ISSN0270-6474
文章类型Article
卷号38期号:9页码:2270-2282
Q分类Q1
产权排序3
摘要Relapse to methamphetamine (Meth) seeking progressively increases after withdrawal from drug self-administration (incubation of Meth craving). We previously demonstrated a role of dorsomedial striatum (DMS) dopamine D1 receptors (D1Rs) in this incubation. Here, we studied the role of afferent glutamatergic projections into the DMS and local D1R-glutamate interaction in this incubation in male rats. We first measured projection-specific activation on day 30 relapse test by using cholera toxin b (retrograde tracer) + Fos (activity marker) double-labeling in projection areas. Next, we determined the effect of pharmacological reversible inactivation of lateral or medial anterior intralaminar nuclei of thalamus (AIT-L or AIT-M) on incubated Meth seeking on withdrawal day 30. We then used an anatomical asymmetrical disconnection procedure to determine whether an interaction between AIT-L -> DMS glutamatergic projections and postsynaptic DMS D1Rs contributes to incubated Meth seeking. We also determined the effect of unilateral inactivation of AIT-L and D1R blockade of DMS on incubated Meth seeking, and the effect of contralateral disconnection of AIT-L -> DMS projections on nonincubated Meth seeking on withdrawal day 1. Incubated Meth seeking was associated with selective activation of AIT -> DMS projections; other glutamatergic projections to DMS were not activated. AIT-L (but not AIT-M) inactivation or anatomical disconnection of AIT-L -> DMS projections decreased incubated Meth seeking. Unilateral inactivation of AIT-L or D1R blockade of the DMS had no effect on incubated Meth craving, and contralateral disconnection of AIT-L -> DMS projections had no effect on nonincubated Meth seeking. Our results identify a novel role of AIT-L and AIT-L -> DMS glutamatergic projections in incubation of drug craving and drug seeking.
关键词anterior intralaminar nuclei of thalamus dorsomedial striatum glutamate methamphetamine relapse retrograde tracing
DOI10.1523/JNEUROSCI.2873-17.2018
收录类别SCI
语种英语
项目资助者National Institute on Drug Abuse, National Institutes of Health ; China Scholarship Council(201604910135)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000426357200011
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]CONTEXT-INDUCED REINSTATEMENT ; PUNISHMENT-IMPOSED ABSTINENCE ; EXTINGUISHED REWARD SEEKING ; COCAINE-SEEKING ; BASOLATERAL AMYGDALA ; PREFRONTAL CORTEX ; DORSAL STRIATUM ; INDUCED RELAPSE ; HEROIN SEEKING ; DRUG-SEEKING
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25723
专题中国科学院心理健康重点实验室
通讯作者Shaham, Yavin
作者单位1.NIDA, Behav Neurosci Res Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA
2.Univ Maryland, Dept Psychol, College Pk, MD 20742 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Li, Xuan,Witonsky, Kailyn R.,Lofaro, Olivia M.,et al. Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving[J]. JOURNAL OF NEUROSCIENCE,2018,38(9):2270-2282.
APA Li, Xuan.,Witonsky, Kailyn R..,Lofaro, Olivia M..,Surjono, Felicia.,Zhang, Jianjun.,...&Shaham, Yavin.(2018).Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving.JOURNAL OF NEUROSCIENCE,38(9),2270-2282.
MLA Li, Xuan,et al."Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving".JOURNAL OF NEUROSCIENCE 38.9(2018):2270-2282.
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