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Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving
Li, Xuan1,2; Witonsky, Kailyn R.1; Lofaro, Olivia M.1; Surjono, Felicia1; Zhang, Jianjun1,3; Bossert, Jennifer M.1; Shaham, Yavin1
First AuthorLi, Xuan
2018-02-28
Source PublicationJOURNAL OF NEUROSCIENCE
ISSN0270-6474
SubtypeArticle
Volume38Issue:9Pages:2270-2282
QuartileQ1
Contribution Rank3
AbstractRelapse to methamphetamine (Meth) seeking progressively increases after withdrawal from drug self-administration (incubation of Meth craving). We previously demonstrated a role of dorsomedial striatum (DMS) dopamine D1 receptors (D1Rs) in this incubation. Here, we studied the role of afferent glutamatergic projections into the DMS and local D1R-glutamate interaction in this incubation in male rats. We first measured projection-specific activation on day 30 relapse test by using cholera toxin b (retrograde tracer) + Fos (activity marker) double-labeling in projection areas. Next, we determined the effect of pharmacological reversible inactivation of lateral or medial anterior intralaminar nuclei of thalamus (AIT-L or AIT-M) on incubated Meth seeking on withdrawal day 30. We then used an anatomical asymmetrical disconnection procedure to determine whether an interaction between AIT-L -> DMS glutamatergic projections and postsynaptic DMS D1Rs contributes to incubated Meth seeking. We also determined the effect of unilateral inactivation of AIT-L and D1R blockade of DMS on incubated Meth seeking, and the effect of contralateral disconnection of AIT-L -> DMS projections on nonincubated Meth seeking on withdrawal day 1. Incubated Meth seeking was associated with selective activation of AIT -> DMS projections; other glutamatergic projections to DMS were not activated. AIT-L (but not AIT-M) inactivation or anatomical disconnection of AIT-L -> DMS projections decreased incubated Meth seeking. Unilateral inactivation of AIT-L or D1R blockade of the DMS had no effect on incubated Meth craving, and contralateral disconnection of AIT-L -> DMS projections had no effect on nonincubated Meth seeking. Our results identify a novel role of AIT-L and AIT-L -> DMS glutamatergic projections in incubation of drug craving and drug seeking.
Keywordanterior intralaminar nuclei of thalamus dorsomedial striatum glutamate methamphetamine relapse retrograde tracing
DOI10.1523/JNEUROSCI.2873-17.2018
Indexed BySCI
Language英语
Funding OrganizationNational Institute on Drug Abuse, National Institutes of Health ; China Scholarship Council(201604910135)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000426357200011
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordCONTEXT-INDUCED REINSTATEMENT ; PUNISHMENT-IMPOSED ABSTINENCE ; EXTINGUISHED REWARD SEEKING ; COCAINE-SEEKING ; BASOLATERAL AMYGDALA ; PREFRONTAL CORTEX ; DORSAL STRIATUM ; INDUCED RELAPSE ; HEROIN SEEKING ; DRUG-SEEKING
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25723
Collection中国科学院心理健康重点实验室
Corresponding AuthorShaham, Yavin
Affiliation1.NIDA, Behav Neurosci Res Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA
2.Univ Maryland, Dept Psychol, College Pk, MD 20742 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Li, Xuan,Witonsky, Kailyn R.,Lofaro, Olivia M.,et al. Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving[J]. JOURNAL OF NEUROSCIENCE,2018,38(9):2270-2282.
APA Li, Xuan.,Witonsky, Kailyn R..,Lofaro, Olivia M..,Surjono, Felicia.,Zhang, Jianjun.,...&Shaham, Yavin.(2018).Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving.JOURNAL OF NEUROSCIENCE,38(9),2270-2282.
MLA Li, Xuan,et al."Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving".JOURNAL OF NEUROSCIENCE 38.9(2018):2270-2282.
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