Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving

doi:10.1523/JNEUROSCI.2873-17.2018

	Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving
	Li, Xuan 1,2; Witonsky, Kailyn R.1; Lofaro, Olivia M.1; Surjono, Felicia 1; Zhang, Jianjun1,3 ; Bossert, Jennifer M.1; Shaham, Yavin 1
第一作者	Li, Xuan
心理所单位排序	3
摘要	Relapse to methamphetamine (Meth) seeking progressively increases after withdrawal from drug self-administration (incubation of Meth craving). We previously demonstrated a role of dorsomedial striatum (DMS) dopamine D1 receptors (D1Rs) in this incubation. Here, we studied the role of afferent glutamatergic projections into the DMS and local D1R-glutamate interaction in this incubation in male rats. We first measured projection-specific activation on day 30 relapse test by using cholera toxin b (retrograde tracer) + Fos (activity marker) double-labeling in projection areas. Next, we determined the effect of pharmacological reversible inactivation of lateral or medial anterior intralaminar nuclei of thalamus (AIT-L or AIT-M) on incubated Meth seeking on withdrawal day 30. We then used an anatomical asymmetrical disconnection procedure to determine whether an interaction between AIT-L -> DMS glutamatergic projections and postsynaptic DMS D1Rs contributes to incubated Meth seeking. We also determined the effect of unilateral inactivation of AIT-L and D1R blockade of DMS on incubated Meth seeking, and the effect of contralateral disconnection of AIT-L -> DMS projections on nonincubated Meth seeking on withdrawal day 1. Incubated Meth seeking was associated with selective activation of AIT -> DMS projections; other glutamatergic projections to DMS were not activated. AIT-L (but not AIT-M) inactivation or anatomical disconnection of AIT-L -> DMS projections decreased incubated Meth seeking. Unilateral inactivation of AIT-L or D1R blockade of the DMS had no effect on incubated Meth craving, and contralateral disconnection of AIT-L -> DMS projections had no effect on nonincubated Meth seeking. Our results identify a novel role of AIT-L and AIT-L -> DMS glutamatergic projections in incubation of drug craving and drug seeking.
关键词	anterior intralaminar nuclei of thalamus dorsomedial striatum glutamate methamphetamine relapse retrograde tracing
	2018-02-28
语种	英语
DOI	10.1523/JNEUROSCI.2873-17.2018
发表期刊	JOURNAL OF NEUROSCIENCE
ISSN	0270-6474
卷号	38 期号:9 页码:2270-2282
期刊论文类型	Article
收录类别	SCI
WOS关键词	CONTEXT-INDUCED REINSTATEMENT ; PUNISHMENT-IMPOSED ABSTINENCE ; EXTINGUISHED REWARD SEEKING ; COCAINE-SEEKING ; BASOLATERAL AMYGDALA ; PREFRONTAL CORTEX ; DORSAL STRIATUM ; INDUCED RELAPSE ; HEROIN SEEKING ; DRUG-SEEKING
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000426357200011
Q分类	Q1
资助机构	National Institute on Drug Abuse, National Institutes of Health ; China Scholarship Council(201604910135)
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/25723
专题	中国科学院心理健康重点实验室
通讯作者	Shaham, Yavin
作者单位	1.NIDA, Behav Neurosci Res Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA 2.Univ Maryland, Dept Psychol, College Pk, MD 20742 USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Li, Xuan,Witonsky, Kailyn R.,Lofaro, Olivia M.,et al. Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving[J]. JOURNAL OF NEUROSCIENCE,2018,38(9):2270-2282.
APA	Li, Xuan.,Witonsky, Kailyn R..,Lofaro, Olivia M..,Surjono, Felicia.,Zhang, Jianjun.,...&Shaham, Yavin.(2018).Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving.JOURNAL OF NEUROSCIENCE,38(9),2270-2282.
MLA	Li, Xuan,et al."Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving".JOURNAL OF NEUROSCIENCE 38.9(2018):2270-2282.

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