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| Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving | |
Li, Xuan1,2; Witonsky, Kailyn R.1; Lofaro, Olivia M.1; Surjono, Felicia1; Zhang, Jianjun1,3 ; Bossert, Jennifer M.1; Shaham, Yavin1
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| First Author | Li, Xuan |
| 2018-02-28 | |
| Source Publication | JOURNAL OF NEUROSCIENCE
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| ISSN | 0270-6474 |
| Subtype | Article |
| Volume | 38Issue:9Pages:2270-2282 |
| Quartile | Q1 |
| Contribution Rank | 3 |
| Abstract | Relapse to methamphetamine (Meth) seeking progressively increases after withdrawal from drug self-administration (incubation of Meth craving). We previously demonstrated a role of dorsomedial striatum (DMS) dopamine D1 receptors (D1Rs) in this incubation. Here, we studied the role of afferent glutamatergic projections into the DMS and local D1R-glutamate interaction in this incubation in male rats. We first measured projection-specific activation on day 30 relapse test by using cholera toxin b (retrograde tracer) + Fos (activity marker) double-labeling in projection areas. Next, we determined the effect of pharmacological reversible inactivation of lateral or medial anterior intralaminar nuclei of thalamus (AIT-L or AIT-M) on incubated Meth seeking on withdrawal day 30. We then used an anatomical asymmetrical disconnection procedure to determine whether an interaction between AIT-L -> DMS glutamatergic projections and postsynaptic DMS D1Rs contributes to incubated Meth seeking. We also determined the effect of unilateral inactivation of AIT-L and D1R blockade of DMS on incubated Meth seeking, and the effect of contralateral disconnection of AIT-L -> DMS projections on nonincubated Meth seeking on withdrawal day 1. Incubated Meth seeking was associated with selective activation of AIT -> DMS projections; other glutamatergic projections to DMS were not activated. AIT-L (but not AIT-M) inactivation or anatomical disconnection of AIT-L -> DMS projections decreased incubated Meth seeking. Unilateral inactivation of AIT-L or D1R blockade of the DMS had no effect on incubated Meth craving, and contralateral disconnection of AIT-L -> DMS projections had no effect on nonincubated Meth seeking. Our results identify a novel role of AIT-L and AIT-L -> DMS glutamatergic projections in incubation of drug craving and drug seeking. |
| Keyword | anterior intralaminar nuclei of thalamus dorsomedial striatum glutamate methamphetamine relapse retrograde tracing |
| DOI | 10.1523/JNEUROSCI.2873-17.2018 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Organization | National Institute on Drug Abuse, National Institutes of Health ; China Scholarship Council(201604910135) |
| WOS Research Area | Neurosciences & Neurology |
| WOS Subject | Neurosciences |
| WOS ID | WOS:000426357200011 |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| WOS Keyword | CONTEXT-INDUCED REINSTATEMENT ; PUNISHMENT-IMPOSED ABSTINENCE ; EXTINGUISHED REWARD SEEKING ; COCAINE-SEEKING ; BASOLATERAL AMYGDALA ; PREFRONTAL CORTEX ; DORSAL STRIATUM ; INDUCED RELAPSE ; HEROIN SEEKING ; DRUG-SEEKING |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/25723 |
| Collection | 中国科学院心理健康重点实验室 |
| Corresponding Author | Shaham, Yavin |
| Affiliation | 1.NIDA, Behav Neurosci Res Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA 2.Univ Maryland, Dept Psychol, College Pk, MD 20742 USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Xuan,Witonsky, Kailyn R.,Lofaro, Olivia M.,et al. Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving[J]. JOURNAL OF NEUROSCIENCE,2018,38(9):2270-2282. |
| APA | Li, Xuan.,Witonsky, Kailyn R..,Lofaro, Olivia M..,Surjono, Felicia.,Zhang, Jianjun.,...&Shaham, Yavin.(2018).Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving.JOURNAL OF NEUROSCIENCE,38(9),2270-2282. |
| MLA | Li, Xuan,et al."Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving".JOURNAL OF NEUROSCIENCE 38.9(2018):2270-2282. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2018 JN Role of Ante（2931KB） | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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