Impaired Working Memory Updating for Emotional Stimuli in Depressed Patients

doi:10.3389/fnbeh.2018.00065

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	Impaired Working Memory Updating for Emotional Stimuli in Depressed Patients
	Zhang, Dandan 1,2; Xie, Hui 2; He, Zhenhong 2; Wei, Zhaoguo 3; Gu, Ruolei1,4
第一作者	Zhang, Dandan ; Xie, Hui
通讯作者邮箱	gurl@psych.ac.cn
心理所单位排序	1
摘要	Although two previous studies have demonstrated that depressed individuals showed deficits in working memory (WM) updating of both negative and positive contents, the effects were confounded by shifting dysfunctions and the detailed neural mechanism associated with the failure in N-back task is not clear. Using a 2-back task, the current study examined the WM updating of positive, negative and neutral contents in depressed patients. It is found that depressed patients performed poorer than healthy controls only when updating positive material. Using event-related potential (ERP) technique, the current study also investigated the neural correlates of updating deficits in depression. According to previous studies, the n-back task was divided into three sub-processes, i.e., encoding, matching and maintaining. Our ERP results showed that depressed patients had smaller occipital P1 for positive material compared to healthy controls, indicating their insensitivity to positive items on early encoding stage. Besides, depressed patients had larger frontal P2 and parietal late positive potential (LPP) than healthy controls irrespective of the valence of the words, reflecting that patients are inefficient during matching (P2) and maintaining (LPP) processes. These two mechanisms (insufficient attention to positive stimuli and low efficiency in matching and maintaining) together lead to the deficits of WM updating in depression.
关键词	depression working memory emotion updating N-back task
	2018-04-04
语种	英语
DOI	10.3389/fnbeh.2018.00065
发表期刊	FRONTIERS IN BEHAVIORAL NEUROSCIENCE
ISSN	1662-5153
卷号	12 期号:0 页码:65
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	EVENT-RELATED POTENTIALS ; N-BACK TASK ; CARD SORTING TEST ; MAJOR DEPRESSION ; SELECTIVE ATTENTION ; UNIPOLAR DEPRESSION ; COGNITIVE IMPAIRMENT ; CLINICAL DEPRESSION ; EXECUTIVE FUNCTIONS ; BRAIN POTENTIALS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS类目	Behavioral Sciences ; Neurosciences
WOS记录号	WOS:000429279500001
Q分类	Q2
资助机构	National Natural Science Foundation of China(31571120) ; National Key Basic Research Program of China (973 Program)(2014CB744600) ; Training Program for Excellent Young College Faculty in Guangdong(YQ2015143) ; Shenzhen Basic Research Project(JCYJ20170302143246158) ; Project for Young Faculty of Humanities and Social Sciences in Shenzhen University(17QNFC43)
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/25741
专题	社会与工程心理学研究室
通讯作者	Gu, Ruolei
作者单位	1.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 2.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China 3.Shenzhen Kangning Hosp, Dept Clin Psychol, Shenzhen, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
第一作者单位	中国科学院行为科学重点实验室
通讯作者单位	中国科学院行为科学重点实验室
推荐引用方式 GB/T 7714	Zhang, Dandan,Xie, Hui,He, Zhenhong,et al. Impaired Working Memory Updating for Emotional Stimuli in Depressed Patients[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2018,12(0):65.
APA	Zhang, Dandan,Xie, Hui,He, Zhenhong,Wei, Zhaoguo,&Gu, Ruolei.(2018).Impaired Working Memory Updating for Emotional Stimuli in Depressed Patients.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,12(0),65.
MLA	Zhang, Dandan,et al."Impaired Working Memory Updating for Emotional Stimuli in Depressed Patients".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 12.0(2018):65.

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