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Impaired Working Memory Updating for Emotional Stimuli in Depressed Patients
Zhang, Dandan1,2; Xie, Hui2; He, Zhenhong2; Wei, Zhaoguo3; Gu, Ruolei1,4
First AuthorZhang, Dandan ; Xie, Hui
2018-04-04
Source PublicationFRONTIERS IN BEHAVIORAL NEUROSCIENCE
Correspondent Emailgurl@psych.ac.cn
ISSN1662-5153
SubtypeArticle
Volume12Issue:0Pages:65
QuartileQ2
Contribution Rank1
AbstractAlthough two previous studies have demonstrated that depressed individuals showed deficits in working memory (WM) updating of both negative and positive contents, the effects were confounded by shifting dysfunctions and the detailed neural mechanism associated with the failure in N-back task is not clear. Using a 2-back task, the current study examined the WM updating of positive, negative and neutral contents in depressed patients. It is found that depressed patients performed poorer than healthy controls only when updating positive material. Using event-related potential (ERP) technique, the current study also investigated the neural correlates of updating deficits in depression. According to previous studies, the n-back task was divided into three sub-processes, i.e., encoding, matching and maintaining. Our ERP results showed that depressed patients had smaller occipital P1 for positive material compared to healthy controls, indicating their insensitivity to positive items on early encoding stage. Besides, depressed patients had larger frontal P2 and parietal late positive potential (LPP) than healthy controls irrespective of the valence of the words, reflecting that patients are inefficient during matching (P2) and maintaining (LPP) processes. These two mechanisms (insufficient attention to positive stimuli and low efficiency in matching and maintaining) together lead to the deficits of WM updating in depression.
Keyworddepression working memory emotion updating N-back task
DOI10.3389/fnbeh.2018.00065
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31571120) ; National Key Basic Research Program of China (973 Program)(2014CB744600) ; Training Program for Excellent Young College Faculty in Guangdong(YQ2015143) ; Shenzhen Basic Research Project(JCYJ20170302143246158) ; Project for Young Faculty of Humanities and Social Sciences in Shenzhen University(17QNFC43)
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000429279500001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordEVENT-RELATED POTENTIALS ; N-BACK TASK ; CARD SORTING TEST ; MAJOR DEPRESSION ; SELECTIVE ATTENTION ; UNIPOLAR DEPRESSION ; COGNITIVE IMPAIRMENT ; CLINICAL DEPRESSION ; EXECUTIVE FUNCTIONS ; BRAIN POTENTIALS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25741
Collection社会与工程心理学研究室
Corresponding AuthorGu, Ruolei
Affiliation1.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
2.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China
3.Shenzhen Kangning Hosp, Dept Clin Psychol, Shenzhen, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Dandan,Xie, Hui,He, Zhenhong,et al. Impaired Working Memory Updating for Emotional Stimuli in Depressed Patients[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2018,12(0):65.
APA Zhang, Dandan,Xie, Hui,He, Zhenhong,Wei, Zhaoguo,&Gu, Ruolei.(2018).Impaired Working Memory Updating for Emotional Stimuli in Depressed Patients.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,12(0),65.
MLA Zhang, Dandan,et al."Impaired Working Memory Updating for Emotional Stimuli in Depressed Patients".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 12.0(2018):65.
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