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Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex
Yan, Chao1,2; Su, Li3; Wang, Yi1; Xu, Ting1; Yin, Dazhi4; Fan, Mingxia5; Deng, Ciping2; Hu, Yang2; Wang, Zhaoxin2; Cheung, Eric F. C.6; Lim, Kelvin O.7; Chan, Raymond C. K.1
First AuthorYan, Chao
2016
Source PublicationScientific Reports
Correspondent Emailrckchan@psych.ac.cn
ISSN2045-2322
SubtypeArticle
Volume6Pages:29079
QuartileQ1
Contribution Rank1
Abstract

The role of the orbitofrontal cortex (OFC) in value processing is a focus of research. Conventional imaging analysis, where smoothing and averaging are employed, may not be sufficiently sensitive in studying the OFC, which has heterogeneous anatomical structures and functions. In this study, we employed representational similarity analysis (RSA) to reveal the multi-voxel fMRI patterns in the OFC associated with value processing during the anticipatory and the consummatory phases. We found that multi-voxel activation patterns in the OFC encoded magnitude and partial valence information (win vs. loss) but not outcome (favourable vs. unfavourable) during reward consummation. Furthermore, the lateral OFC rather than the medial OFC encoded loss information. Also, we found that OFC encoded values in a similar way to the ventral striatum (VS) or the anterior insula (AI) during reward anticipation regardless of motivated response and to the medial prefrontal cortex (MPFC) and the VS in reward consummation. In contrast, univariate analysis did not show changes of activation in the OFC. These findings suggest an important role of the OFC in value processing during reward anticipation and consummation.

KeywordHUMAN BRAIN DECISION-MAKING NUCLEUS-ACCUMBENS TEMPORAL CORTEX FRONTAL-CORTEX VALENCE CONNECTIVITY MAGNITUDE MONETARY ANTERIOR
DOI10.1038/srep29079
Indexed BySCI
Language英语
WOS IDWOS:000379189700001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25744
Collection中国科学院心理健康重点实验室
健康与遗传心理学研究室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Room 606,South Bldg,16 Lincui Rd, Beijing 100101, Peoples R China
2.East China Normal Univ, Shanghai Key Lab Brain Funct Genom MOE STCSM, Key Lab Brain Funct Genom, Minist Educ, Room 213,Junxiu Bldg,3663 North Zhongshan Rd, Shanghai 200062, Peoples R China
3.Univ Cambridge, Dept Psychiat, Cambridge Biomed Campus, Cambridge CB2 0SP, England
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China
5.East China Normal Univ, Shanghai Key Lab MRI, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China
6.Castle Peak Hosp, Dept Gen Adult Psychiat, 15 Tsing Chung Koon Rd, Tuen Mun, Hong Kong, Peoples R China
7.Univ Minnesota, Dept Psychiat, F282-2A West 2450 Riverside Ave, Minneapolis, MN 55454 USA
Recommended Citation
GB/T 7714
Yan, Chao,Su, Li,Wang, Yi,et al. Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex[J]. Scientific Reports,2016,6:29079.
APA Yan, Chao.,Su, Li.,Wang, Yi.,Xu, Ting.,Yin, Dazhi.,...&Chan, Raymond C. K..(2016).Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex.Scientific Reports,6,29079.
MLA Yan, Chao,et al."Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex".Scientific Reports 6(2016):29079.
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