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Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults
Wang, Yi1; Ettinger, Ulrich2; Meindl, Thomas3; Chan, Raymond C. K.1,4; Chan, Raymond C K
First AuthorWang, Yi
2018
Source PublicationHUMAN BRAIN MAPPING
Correspondent Emailrckchan@psych.ac.cn ; ulrich.ettinger@uni-bonn.de
ISSN1065-9471
SubtypeArticle
Volume39Issue:1Pages:288-299
QuartileQ1
Contribution Rank1
AbstractAltered striatocortical functional connectivity has been suggested to be a trait marker of schizophrenia spectrum disorders, including schizotypal personality. In the present study, we examined the association between schizotypal personality traits and striatocortical functional connectivity in a sample of healthy adults. The German version of the Schizotypal Personality Questionnaire was obtained from N=111 participants recruited from the general public. Resting-state functional magnetic resonance imaging scans were acquired at 3T. Six striatal seed regions in each hemisphere were defined and striatocortical resting-state functional connectivity (rsFC) as well as its lateralization indices was calculated. Regression analysis showed that schizotypy scores, especially from the positive dimension, were positively correlated with rsFC between ventral striatum and frontal cortex and negatively associated with rsFC between dorsal striatum and posterior cingulate. No significant associations were found between negative dimension schizotypy and striatocortical rsFC. We also found positive correlations between schizotypy total scores and lateralization index of right dorsal caudate and right rostral putamen. In conclusion, the present study extends previous evidence of altered striatocortical rsFC in the schizophrenia spectrum. The observed associations resemble in part the alterations observed in psychotic patients and their relatives, providing support for dimensionality from schizotypal personality to the clinical disorder. Hum Brain Mapp 39:288-299, 2018. (c) 2017 Wiley Periodicals, Inc.
Keywordschizotypy functional magnetic resonance imaging resting state connectivity striatum lateralization
DOI10.1002/hbm.23842
Indexed BySCI
Language英语
Funding OrganizationDFG(Et 31/2-1) ; National Basic Research Programme of China(2016YFC0906402) ; Beijing Training Project for Leading Talents in ST(Z151100000315020) ; Beijing Municipal Science & Technology Commission(Z161100000216138) ; National Science Fund China(81571317 ; China Scholarship Council ; 31400884)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000417282000019
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordIII-R CRITERIA ; PSYCHOMETRIC SCHIZOTYPY ; CORTICOSTRIATAL CIRCUITRY ; NEGATIVE SCHIZOTYPY ; BRAIN STRUCTURE ; EYE TRACKING ; CANNABIS USE ; SCHIZOPHRENIA ; PERSONALITY ; PSYCHOSIS
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/25748
Collection中国科学院心理健康重点实验室
健康与遗传心理学研究室
Corresponding AuthorEttinger, Ulrich; Chan, Raymond C K
Affiliation1.CAS Key Lab Mental Hlth, Inst Psychol, Neuropsychol & Appl Cognit Neurosci NACN Lab, Beijing, Peoples R China
2.Univ Bonn, Dept Psychol, Kaiser Karl Ring 9, D-53111 Bonn, Germany
3.Univ Munich, Inst Clin Radiol, Munich, Germany
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yi,Ettinger, Ulrich,Meindl, Thomas,et al. Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults[J]. HUMAN BRAIN MAPPING,2018,39(1):288-299.
APA Wang, Yi,Ettinger, Ulrich,Meindl, Thomas,Chan, Raymond C. K.,&Chan, Raymond C K.(2018).Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults.HUMAN BRAIN MAPPING,39(1),288-299.
MLA Wang, Yi,et al."Association of schizotypy with striatocortical functional connectivity and its asymmetry in healthy adults".HUMAN BRAIN MAPPING 39.1(2018):288-299.
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