PSYCH OpenIR  > 中国科学院行为科学重点实验室
Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson’s disease: a resting-state fMRI study
Hu, Xiaopeng1; Chen, Siyi2,3; Huang, Changbing2; Qian, Yinfeng1; Yongqiang Yu1; Yu, Yongqiang
第一作者Hu, Xiaopeng ; Chen, Siyi
2017
发表期刊Metabolic Brain Disease
通讯作者邮箱894206876@qq.com ; Cjr.yuyongqiang@vip.163.com
ISSN0885-7490
文章类型Article
卷号32期号:3页码:685-692
Q分类Q3
产权排序2
其他摘要

To investigate the frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) in patients with Wilson's disease (WD). Resting-state function magnetic resonance imaging (R-fMRI) were employed to measure the amplitude of ALFF in 28 patients with WD and 27 matched normal controls. Slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.073 Hz) frequency bands were analyzed. Apart from the observation of atrophy in the cerebellum, basal ganglia, occipital gyrus, frontal gyrus, precentral gyrus, and paracentral lobule, we also found widespread differences in ALFF of the two bands in the medial frontal gyrus, inferior temporal gyrus, insula, basal ganglia, hippocampus/parahippocampal gyrus, and thalamus bilaterally. Compared to normal controls, WD patients had increased ALFF in the posterior lobe of the cerebellum, inferior temporal gyrus, brain stem, basal ganglia, and decreased ALFF in the anterior lobe of the cerebellum and medial frontal gyrus. Specifically, we observed that the ALFF abnormalities in the cerebellum and middle frontal gyrus were greater in the slow-5 than in the slow-4 band. Correlation analysis showed consistently positive correlations between urinary copper excretion (Cu), serum ceruloplasmin (CP) and ALFFs in the cerebellum. Our study suggests the accumulation of copper profoundly impaired intrinsic brain activity and the impairments seem to be frequency-dependent. These results provide further insights into the understanding of the pathophysiology of WD.

关键词Wilson's disease Resting-state functional magnetic resonance imaging Amplitude of low-frequency fluctuations
DOI10.1007/s11011-016-9946-3
收录类别SCI
语种英语
WOS记录号WOS:000400767700005
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/25761
专题中国科学院行为科学重点实验室
通讯作者Qian, Yinfeng; Yu, Yongqiang
作者单位1.Department of Radiology, First Affiliated Hospital of AnhuiMedical University, Hefei 230022, China
2.Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
3.Department Psychologie, Ludwig-Maximilians-Universität, 80802 Munich, Germany
推荐引用方式
GB/T 7714
Hu, Xiaopeng,Chen, Siyi,Huang, Changbing,等. Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson’s disease: a resting-state fMRI study[J]. Metabolic Brain Disease,2017,32(3):685-692.
APA Hu, Xiaopeng,Chen, Siyi,Huang, Changbing,Qian, Yinfeng,Yongqiang Yu,&Yu, Yongqiang.(2017).Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson’s disease: a resting-state fMRI study.Metabolic Brain Disease,32(3),685-692.
MLA Hu, Xiaopeng,et al."Frequency-dependent changes in the amplitude of low-frequency fluctuations in patients with Wilson’s disease: a resting-state fMRI study".Metabolic Brain Disease 32.3(2017):685-692.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
frequency-dependent (2619KB)期刊论文作者接受稿暂不开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hu, Xiaopeng]的文章
[Chen, Siyi]的文章
[Huang, Changbing]的文章
百度学术
百度学术中相似的文章
[Hu, Xiaopeng]的文章
[Chen, Siyi]的文章
[Huang, Changbing]的文章
必应学术
必应学术中相似的文章
[Hu, Xiaopeng]的文章
[Chen, Siyi]的文章
[Huang, Changbing]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。