PSYCH OpenIR  > 中国科学院心理健康重点实验室
Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features
Li, Wei1,2; Wu, Xiaoli1,2; Hu, Xu1; Wang, Tao1; Liang, Shan1,2; Duan, Yunfeng1; Jin, Feng1; Qin, Bin3; Feng Jin; Bin Qin
通讯作者邮箱jinfeng@psych.ac.cn ; bin_chin@hotmail.com
心理所单位排序1
摘要

The aim of this study was to compare the structure of gut microbiota in Parkinson's disease (PD) patients and healthy controls; and to explore correlations between gut microbiota and PD clinical features. We analyzed fecal bacterial composition of 24 PD patients and 14 healthy volunteers by using 16S rRNA sequencing. There were significant differences between PD and healthy controls, as well as among different PD stages. The putative cellulose degrading bacteria from the genera Blautia (P=0.018), Faecalibacterium (P=0.048) and Ruminococcus (P=0.019) were significantly decreased in PD compared to healthy controls. The putative pathobionts from the genera Escherichia-Shigella (P=0.038), Streptococcus (P=0.01), Proteus (P=0.022), and Enterococcus (P=0.006) were significantly increased in PD subjects. Correlation analysis indicated that disease severity and PD duration negatively correlated with the putative cellulose degraders, and positively correlated with the putative pathobionts. The results suggest that structural changes of gut microbiota in PD are characterized by the decreases of putative cellulose degraders and the increases of putative pathobionts, which may potentially reduce the production of short chain fatty acids, and produce more endotoxins and neurotoxins; and these changes is potentially associated with the development of PD pathology.

关键词microbiome alpha-synuclein gastrointestinal dysfunction gut-brain-axis 16S rRNA sequencing short chain fatty acids
2017-11-01
语种英语
DOI10.1007/s11427-016-9001-4
发表期刊SCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
卷号60期号:11页码:1223-1233
期刊论文类型Article
收录类别SCI
WOS关键词INTESTINAL BACTERIAL OVERGROWTH ; CENTRAL-NERVOUS-SYSTEM ; CHAIN FATTY-ACIDS ; SEQUENCE DATA ; NONMOTOR SYMPTOMS ; RESISTANT STARCH ; SHIGELLA-SHIGAE ; LIVER-CIRRHOSIS ; BRAIN ; DIAGNOSIS
WOS标题词Science & Technology ; Life Sciences & Biomedicine
WOS研究方向Life Sciences & Biomedicine - Other Topics
WOS类目Biology
WOS记录号WOS:000417936900008
资助机构Future Life Sciences International Ltd.(NSBJ01032014)
引用统计
被引频次:247[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26008
专题中国科学院心理健康重点实验室
通讯作者Feng Jin; Bin Qin
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Beijing Hosp, Dept Neurol, Beijing 100730, Peoples R China
第一作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Li, Wei,Wu, Xiaoli,Hu, Xu,et al. Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features[J]. SCIENCE CHINA-LIFE SCIENCES,2017,60(11):1223-1233.
APA Li, Wei.,Wu, Xiaoli.,Hu, Xu.,Wang, Tao.,Liang, Shan.,...&Bin Qin.(2017).Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features.SCIENCE CHINA-LIFE SCIENCES,60(11),1223-1233.
MLA Li, Wei,et al."Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features".SCIENCE CHINA-LIFE SCIENCES 60.11(2017):1223-1233.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Structural changes o(1303KB)期刊论文出版稿限制开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Wei]的文章
[Wu, Xiaoli]的文章
[Hu, Xu]的文章
百度学术
百度学术中相似的文章
[Li, Wei]的文章
[Wu, Xiaoli]的文章
[Hu, Xu]的文章
必应学术
必应学术中相似的文章
[Li, Wei]的文章
[Wu, Xiaoli]的文章
[Hu, Xu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。