PSYCH OpenIR  > 中国科学院心理健康重点实验室
Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features
Li, Wei1,2; Wu, Xiaoli1,2; Hu, Xu1; Wang, Tao1; Liang, Shan1,2; Duan, Yunfeng1; Jin, Feng1; Qin, Bin3; Feng Jin; Bin Qin
2017-11-01
Source PublicationSCIENCE CHINA-LIFE SCIENCES
Correspondent Emailjinfeng@psych.ac.cn ; bin_chin@hotmail.com
ISSN1674-7305
SubtypeArticle
Volume60Issue:11Pages:1223-1233
Contribution Rank1
Abstract

The aim of this study was to compare the structure of gut microbiota in Parkinson's disease (PD) patients and healthy controls; and to explore correlations between gut microbiota and PD clinical features. We analyzed fecal bacterial composition of 24 PD patients and 14 healthy volunteers by using 16S rRNA sequencing. There were significant differences between PD and healthy controls, as well as among different PD stages. The putative cellulose degrading bacteria from the genera Blautia (P=0.018), Faecalibacterium (P=0.048) and Ruminococcus (P=0.019) were significantly decreased in PD compared to healthy controls. The putative pathobionts from the genera Escherichia-Shigella (P=0.038), Streptococcus (P=0.01), Proteus (P=0.022), and Enterococcus (P=0.006) were significantly increased in PD subjects. Correlation analysis indicated that disease severity and PD duration negatively correlated with the putative cellulose degraders, and positively correlated with the putative pathobionts. The results suggest that structural changes of gut microbiota in PD are characterized by the decreases of putative cellulose degraders and the increases of putative pathobionts, which may potentially reduce the production of short chain fatty acids, and produce more endotoxins and neurotoxins; and these changes is potentially associated with the development of PD pathology.

Keywordmicrobiome alpha-synuclein gastrointestinal dysfunction gut-brain-axis 16S rRNA sequencing short chain fatty acids
DOI10.1007/s11427-016-9001-4
Indexed BySCI
Language英语
Funding OrganizationFuture Life Sciences International Ltd.(NSBJ01032014)
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:000417936900008
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordINTESTINAL BACTERIAL OVERGROWTH ; CENTRAL-NERVOUS-SYSTEM ; CHAIN FATTY-ACIDS ; SEQUENCE DATA ; NONMOTOR SYMPTOMS ; RESISTANT STARCH ; SHIGELLA-SHIGAE ; LIVER-CIRRHOSIS ; BRAIN ; DIAGNOSIS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26008
Collection中国科学院心理健康重点实验室
Corresponding AuthorFeng Jin; Bin Qin
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Beijing Hosp, Dept Neurol, Beijing 100730, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Wei,Wu, Xiaoli,Hu, Xu,et al. Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features[J]. SCIENCE CHINA-LIFE SCIENCES,2017,60(11):1223-1233.
APA Li, Wei.,Wu, Xiaoli.,Hu, Xu.,Wang, Tao.,Liang, Shan.,...&Bin Qin.(2017).Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features.SCIENCE CHINA-LIFE SCIENCES,60(11),1223-1233.
MLA Li, Wei,et al."Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features".SCIENCE CHINA-LIFE SCIENCES 60.11(2017):1223-1233.
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