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Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence
Zhao, Qinglin1; Li, Hongqian1; Hu, Bin1; Li, Yonghui2; Gillebert, Celine R.3,4; Mantini, Dante3,5,6; Liu, Quanying5,6; Bin Hu; Quanying
2018-01-23
发表期刊FRONTIERS IN HUMAN NEUROSCIENCE
通讯作者邮箱bh@lzu.edu.cn ; liu liuqy1989@gmail.com
ISSN1662-5161
文章类型Article
卷号11页码:1-13
产权排序2
摘要

The attention of drug-dependent persons tends to be captured by stimuli associated with drug consumption. This involuntary cognitive process is considered as attentional bias (AB). AB has been hypothesized to have causal effects on drug abuse and drug relapse, but its underlying neural mechanisms are still unclear. This study investigated the neural basis of AB in abstinent heroin addicts (AHAs), combining event-related potential (ERP) analysis and source localization techniques. Electroencephalography data were collected in 21 abstinent heroin addicts and 24 age-and gender-matched healthy controls (HCs) during a dot-probe task. In the task, a pair of drug-related image and neutral image was presented randomly in left and right side of the cross fixation, followed by a dot probe replacing one of the images. Behaviorally, AHAs had shorter reaction times (RTs) for the congruent condition compared to the incongruent condition, whereas this was not the case in the HCs. This finding demonstrated the presence of AB towards drug cues in AHAs. Furthermore, the image-evoked ERPs in AHAs had significant shorter P1 latency compared to HCs, as well as larger N1, N2, and P2 amplitude, suggesting that drug-related stimuli might capture attention early and overall require more attentional resources in AHAs. The target-related P3 had significantly shorter latency and lower amplitude in the congruent than incongruent condition in AHAs compared to HCs. Moreover, source localization of ERP components revealed increased activity for AHAs as compared to HCs in the dorsal posterior cingulate cortex (dPCC), superior parietal lobule and inferior frontal gyrus (IFG) for image-elicited responses, and decreased activity in the occipital and the medial parietal lobes for target-elicited responses. Overall, the results of our study confirmed that AHAs may exhibit AB in drug-related contexts, and suggested that the bias might be related to an abnormal neural activity, both in early and late attention processing stages.

关键词dot-probe task event-related potentials attentional bias source localization heroin-related cues P3
DOI10.3389/fnhum.2017.00646
收录类别SCI ; SSCI
语种英语
项目资助者National Basic Research Program of China (973 Program)(2014CB744600) ; Program of International S&T Cooperation of MOST(2013DFA11140) ; National Natural Science Foundation of China(61210010 ; National Key Foundation for Developing Scientific Instruments(61627808) ; Program of Beijing Municipal Science & Technology Commission(Z171100000117005) ; KU Leuven Special Research Fund(C16/15/070) ; Research Foundation Flanders(G0F76.16N ; 61632014) ; G0936.16N)
WOS研究方向Neurosciences & Neurology ; Psychology
WOS类目Neurosciences ; Psychology
WOS记录号WOS:000423089600002
WOS标题词Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
关键词[WOS]EVENT-RELATED POTENTIALS ; SHORT-TERM-MEMORY ; DOT-PROBE TASK ; EYE-TRACKING ; ELECTROMAGNETIC TOMOGRAPHY ; SPATIAL ATTENTION ; SOCIAL DRINKERS ; PARIETAL CORTEX ; ERP COMPONENTS ; ALCOHOL CUES
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26026
专题中国科学院心理健康重点实验室
通讯作者Bin Hu; Quanying
作者单位1.Lanzhou Univ, Ubiquitous Awareness & Intelligent Solut Lab, Lanzhou, Gansu, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Oxford, Dept Expt Psychol, Oxford, England
4.Katholieke Univ Leuven, Dept Brain & Cognit, Leuven, Belgium
5.Katholieke Univ Leuven, Res Ctr Motor Control & Neuroplast, Leuven, Belgium
6.Swiss Fed Inst Technol, Neural Control Movement Lab, Zurich, Switzerland
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Zhao, Qinglin,Li, Hongqian,Hu, Bin,et al. Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2018,11:1-13.
APA Zhao, Qinglin.,Li, Hongqian.,Hu, Bin.,Li, Yonghui.,Gillebert, Celine R..,...&Quanying.(2018).Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence.FRONTIERS IN HUMAN NEUROSCIENCE,11,1-13.
MLA Zhao, Qinglin,et al."Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence".FRONTIERS IN HUMAN NEUROSCIENCE 11(2018):1-13.
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