Institutional Repository of Key Laboratory of Mental Health, CAS
Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence | |
Zhao, Qinglin1; Li, Hongqian1; Hu, Bin1; Li, Yonghui2![]() | |
通讯作者邮箱 | bh@lzu.edu.cn ; liu liuqy1989@gmail.com |
心理所单位排序 | 2 |
摘要 | The attention of drug-dependent persons tends to be captured by stimuli associated with drug consumption. This involuntary cognitive process is considered as attentional bias (AB). AB has been hypothesized to have causal effects on drug abuse and drug relapse, but its underlying neural mechanisms are still unclear. This study investigated the neural basis of AB in abstinent heroin addicts (AHAs), combining event-related potential (ERP) analysis and source localization techniques. Electroencephalography data were collected in 21 abstinent heroin addicts and 24 age-and gender-matched healthy controls (HCs) during a dot-probe task. In the task, a pair of drug-related image and neutral image was presented randomly in left and right side of the cross fixation, followed by a dot probe replacing one of the images. Behaviorally, AHAs had shorter reaction times (RTs) for the congruent condition compared to the incongruent condition, whereas this was not the case in the HCs. This finding demonstrated the presence of AB towards drug cues in AHAs. Furthermore, the image-evoked ERPs in AHAs had significant shorter P1 latency compared to HCs, as well as larger N1, N2, and P2 amplitude, suggesting that drug-related stimuli might capture attention early and overall require more attentional resources in AHAs. The target-related P3 had significantly shorter latency and lower amplitude in the congruent than incongruent condition in AHAs compared to HCs. Moreover, source localization of ERP components revealed increased activity for AHAs as compared to HCs in the dorsal posterior cingulate cortex (dPCC), superior parietal lobule and inferior frontal gyrus (IFG) for image-elicited responses, and decreased activity in the occipital and the medial parietal lobes for target-elicited responses. Overall, the results of our study confirmed that AHAs may exhibit AB in drug-related contexts, and suggested that the bias might be related to an abnormal neural activity, both in early and late attention processing stages. |
关键词 | dot-probe task event-related potentials attentional bias source localization heroin-related cues P3 |
2018-01-23 | |
语种 | 英语 |
DOI | 10.3389/fnhum.2017.00646 |
发表期刊 | FRONTIERS IN HUMAN NEUROSCIENCE
![]() |
ISSN | 1662-5161 |
卷号 | 11页码:1-13 |
期刊论文类型 | Article |
收录类别 | SCI ; SSCI |
WOS关键词 | EVENT-RELATED POTENTIALS ; SHORT-TERM-MEMORY ; DOT-PROBE TASK ; EYE-TRACKING ; ELECTROMAGNETIC TOMOGRAPHY ; SPATIAL ATTENTION ; SOCIAL DRINKERS ; PARIETAL CORTEX ; ERP COMPONENTS ; ALCOHOL CUES |
WOS标题词 | Science & Technology ; Social Sciences ; Life Sciences & Biomedicine |
WOS研究方向 | Neurosciences & Neurology ; Psychology |
WOS类目 | Neurosciences ; Psychology |
WOS记录号 | WOS:000423089600002 |
资助机构 | National Basic Research Program of China (973 Program)(2014CB744600) ; Program of International S&T Cooperation of MOST(2013DFA11140) ; National Natural Science Foundation of China(61210010 ; National Key Foundation for Developing Scientific Instruments(61627808) ; Program of Beijing Municipal Science & Technology Commission(Z171100000117005) ; KU Leuven Special Research Fund(C16/15/070) ; Research Foundation Flanders(G0F76.16N ; 61632014) ; G0936.16N) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/26026 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Bin Hu; Quanying |
作者单位 | 1.Lanzhou Univ, Ubiquitous Awareness & Intelligent Solut Lab, Lanzhou, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Oxford, Dept Expt Psychol, Oxford, England 4.Katholieke Univ Leuven, Dept Brain & Cognit, Leuven, Belgium 5.Katholieke Univ Leuven, Res Ctr Motor Control & Neuroplast, Leuven, Belgium 6.Swiss Fed Inst Technol, Neural Control Movement Lab, Zurich, Switzerland |
推荐引用方式 GB/T 7714 | Zhao, Qinglin,Li, Hongqian,Hu, Bin,et al. Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2018,11:1-13. |
APA | Zhao, Qinglin.,Li, Hongqian.,Hu, Bin.,Li, Yonghui.,Gillebert, Celine R..,...&Quanying.(2018).Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence.FRONTIERS IN HUMAN NEUROSCIENCE,11,1-13. |
MLA | Zhao, Qinglin,et al."Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence".FRONTIERS IN HUMAN NEUROSCIENCE 11(2018):1-13. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Neural Correlates of(2937KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论