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Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence
Zhao, Qinglin1; Li, Hongqian1; Hu, Bin1; Li, Yonghui2; Gillebert, Celine R.3,4; Mantini, Dante3,5,6; Liu, Quanying5,6; Bin Hu; Quanying
2018-01-23
Source PublicationFRONTIERS IN HUMAN NEUROSCIENCE
Correspondent Emailbh@lzu.edu.cn ; liu liuqy1989@gmail.com
ISSN1662-5161
SubtypeArticle
Volume11Pages:1-13
Contribution Rank2
Abstract

The attention of drug-dependent persons tends to be captured by stimuli associated with drug consumption. This involuntary cognitive process is considered as attentional bias (AB). AB has been hypothesized to have causal effects on drug abuse and drug relapse, but its underlying neural mechanisms are still unclear. This study investigated the neural basis of AB in abstinent heroin addicts (AHAs), combining event-related potential (ERP) analysis and source localization techniques. Electroencephalography data were collected in 21 abstinent heroin addicts and 24 age-and gender-matched healthy controls (HCs) during a dot-probe task. In the task, a pair of drug-related image and neutral image was presented randomly in left and right side of the cross fixation, followed by a dot probe replacing one of the images. Behaviorally, AHAs had shorter reaction times (RTs) for the congruent condition compared to the incongruent condition, whereas this was not the case in the HCs. This finding demonstrated the presence of AB towards drug cues in AHAs. Furthermore, the image-evoked ERPs in AHAs had significant shorter P1 latency compared to HCs, as well as larger N1, N2, and P2 amplitude, suggesting that drug-related stimuli might capture attention early and overall require more attentional resources in AHAs. The target-related P3 had significantly shorter latency and lower amplitude in the congruent than incongruent condition in AHAs compared to HCs. Moreover, source localization of ERP components revealed increased activity for AHAs as compared to HCs in the dorsal posterior cingulate cortex (dPCC), superior parietal lobule and inferior frontal gyrus (IFG) for image-elicited responses, and decreased activity in the occipital and the medial parietal lobes for target-elicited responses. Overall, the results of our study confirmed that AHAs may exhibit AB in drug-related contexts, and suggested that the bias might be related to an abnormal neural activity, both in early and late attention processing stages.

Keyworddot-probe task event-related potentials attentional bias source localization heroin-related cues P3
DOI10.3389/fnhum.2017.00646
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Basic Research Program of China (973 Program)(2014CB744600) ; Program of International S&T Cooperation of MOST(2013DFA11140) ; National Natural Science Foundation of China(61210010 ; National Key Foundation for Developing Scientific Instruments(61627808) ; Program of Beijing Municipal Science & Technology Commission(Z171100000117005) ; KU Leuven Special Research Fund(C16/15/070) ; Research Foundation Flanders(G0F76.16N ; 61632014) ; G0936.16N)
WOS Research AreaNeurosciences & Neurology ; Psychology
WOS SubjectNeurosciences ; Psychology
WOS IDWOS:000423089600002
WOS HeadingsScience & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS KeywordEVENT-RELATED POTENTIALS ; SHORT-TERM-MEMORY ; DOT-PROBE TASK ; EYE-TRACKING ; ELECTROMAGNETIC TOMOGRAPHY ; SPATIAL ATTENTION ; SOCIAL DRINKERS ; PARIETAL CORTEX ; ERP COMPONENTS ; ALCOHOL CUES
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26026
Collection中国科学院心理健康重点实验室
Corresponding AuthorBin Hu; Quanying
Affiliation1.Lanzhou Univ, Ubiquitous Awareness & Intelligent Solut Lab, Lanzhou, Gansu, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Oxford, Dept Expt Psychol, Oxford, England
4.Katholieke Univ Leuven, Dept Brain & Cognit, Leuven, Belgium
5.Katholieke Univ Leuven, Res Ctr Motor Control & Neuroplast, Leuven, Belgium
6.Swiss Fed Inst Technol, Neural Control Movement Lab, Zurich, Switzerland
Recommended Citation
GB/T 7714
Zhao, Qinglin,Li, Hongqian,Hu, Bin,et al. Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2018,11:1-13.
APA Zhao, Qinglin.,Li, Hongqian.,Hu, Bin.,Li, Yonghui.,Gillebert, Celine R..,...&Quanying.(2018).Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence.FRONTIERS IN HUMAN NEUROSCIENCE,11,1-13.
MLA Zhao, Qinglin,et al."Neural Correlates of Drug-Related Attentional Bias in Heroin Dependence".FRONTIERS IN HUMAN NEUROSCIENCE 11(2018):1-13.
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