PSYCH OpenIR  > 中国科学院心理健康重点实验室
Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice
Xu, Hang1,2; Wang, Jiesi1,2; Zhang, Ke1,2; Zhao, Mei1,2; Ellenbroek, Bart4; Shao, Feng3; Wang, Weiwen1,2; F. Shao; W. Wang
2018-02-01
Source PublicationPSYCHONEUROENDOCRINOLOGY
Correspondent Emailshaof@pku.edu.cn ; wangww@psych.ac.cn
ISSN0306-4530
SubtypeArticle
Volume88Pages:92-101
Contribution Rank1
Abstract

Adolescent social stress (ASS) can increase susceptibility to depression in adulthood. However, the underlying psychological and neural mechanisms remain unclear. Cortically mediated cognitive dysfunctions are increasingly recognized as an independent and important risk factor of depression. Using social defeat stress, a classical animal model of depression, our previous studies found that mice subjected to this form of stress during early adolescence displayed cognitive inflexibility (CI) in adulthood. This change was accompanied by a down-regulation of Bdnf gene expression in the medial prefrontal cortex (mPFC); this gene encodes a key molecule involved in depression and antidepressant action. In the present paper, we identified epigenetic modification of Bdnf as a possible mechanism underlying the behavioral and molecular changes. ASS induced a set of depressive phenotypes, including increased social avoidance and CI, as well as reduced levels of total Bdnf and isoform IV but not isoform I or VI transcripts in the mPFC. In parallel with changes in Bdnf gene expression, previously stressed adult mice showed increased levels of dimethylation of histone H3 at lysine K9 (H3K9me2) immediately downstream of the Bdnf 11, promoter. On the other hand, no differences were found in trimethylation of histone H3 at lysine K4 (H3K4me3) or in acetylation of histone H3 at lysine K9 (H3K9ac) or at K4 (H3K4ac) in the Bdnf IV promoter. Likewise, no alterations were found in DNA methylation of the Bdnf IV promoter. Additionally, treatment with the chronic antidepressant tranylcypromine reversed Bdnf epigenetic changes and related gene transcription while also reversing CI, but not social avoidance, in previously stressed adult mice. These results suggest that epigenetic changes to the Bdnf gene in the mPFC after adolescent social adversity may be involved in the regulation of cognitive dysfunction in depression and antidepressant action in adulthood.

KeywordAdolescent Social stress Cognitive inflexibility Brain-derived neurotrophic factor (BDNF) Epigenetic mechanism
DOI10.1016/j.psyneuen.2017.11.013
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81471122 ; Chinese Academy of Sciences(KJZD-EW-L04) ; CAS Key Laboratory of Mental Health, Institute of Psychology ; 31470988)
WOS Research AreaEndocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
WOS SubjectEndocrinology & Metabolism ; Neurosciences ; Psychiatry
WOS IDWOS:000426236000011
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordHISTONE LYSINE METHYLATION ; NEUROTROPHIC FACTOR ; DNA METHYLATION ; PSYCHIATRIC-DISORDERS ; MAJOR DEPRESSION ; PRENATAL STRESS ; ANIMAL-MODELS ; HUMAN GENOME ; MOUSE MODEL ; BRAIN
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26032
Collection中国科学院心理健康重点实验室
Corresponding AuthorF. Shao; W. Wang
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, Beijing, Peoples R China
4.Victoria Univ Wellington, Sch Psychol, Wellington 6012, New Zealand
Recommended Citation
GB/T 7714
Xu, Hang,Wang, Jiesi,Zhang, Ke,et al. Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice[J]. PSYCHONEUROENDOCRINOLOGY,2018,88:92-101.
APA Xu, Hang.,Wang, Jiesi.,Zhang, Ke.,Zhao, Mei.,Ellenbroek, Bart.,...&W. Wang.(2018).Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice.PSYCHONEUROENDOCRINOLOGY,88,92-101.
MLA Xu, Hang,et al."Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice".PSYCHONEUROENDOCRINOLOGY 88(2018):92-101.
Files in This Item:
File Name/Size DocType Version Access License
Effects of adolescen(968KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xu, Hang]'s Articles
[Wang, Jiesi]'s Articles
[Zhang, Ke]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xu, Hang]'s Articles
[Wang, Jiesi]'s Articles
[Zhang, Ke]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xu, Hang]'s Articles
[Wang, Jiesi]'s Articles
[Zhang, Ke]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.