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The Hierarchical Organization of the Default, Dorsal Attention and Salience Networks in Adolescents and Young Adults
Zhou, Yuan1,2,3,4; Friston, Karl J.4; Zeidman, Peter4; Chen, Jie3,5; Li, Shu1,2,3; Razi, Adeel4,6,7,8
2018-02-01
Source PublicationCEREBRAL CORTEX
Correspondent Emailzhouyuan@psych.ac.cn
ISSN1047-3211
SubtypeArticle
Volume28Issue:2Pages:726-737
Contribution Rank1,2
Abstract

An important characteristic of spontaneous brain activity is the anticorrelation between the core default network (cDN) and the dorsal attention network (DAN) and the salience network (SN). This anticorrelation may constitute a key aspect of functional anatomy and is implicated in several brain disorders. We used dynamic causal modeling to assess the hypothesis that a causal hierarchy underlies this anticorrelation structure, using resting-state fMRI of healthy adolescent and young adults (N = 404). Our analysis revealed an asymmetric effective connectivity, such that the regions in the SN and DAN exerted an inhibitory influence on the cDN regions; whereas the cDN exerted an excitatory influence on the SN and DAN regions. The relative strength of efferent versus afferent connections places the SN at the apex of the hierarchy, suggesting that the SN modulates anticorrelated networks with descending hierarchical connections. In short, this study of directed neuronal coupling reveals a causal hierarchical architecture that generates or orchestrates anticorrelation of brain activity. These new findings shed light on functional integration of intrinsic brain networks at rest and speak to future dynamic causal modeling studies of large-scale networks.

Keyworddefault network dorsal attention network dynamic causal modeling resting-state fMRI salience network
DOI10.1093/cercor/bhx307
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(91432302 ; National Basic Research Program of China (973 program)(2011CB711002) ; National High Technology Research and Development Program of China (863 program)(2015AA020513) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2012075) ; Beijing Nova Program(Z121107002512064) ; China Scholarship Council(201504910067) ; Wellcome Trust Principal Research Fellowship(088130/Z/09/Z) ; 81371476 ; 31300841)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000423981700028
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordINTRINSIC FUNCTIONAL CONNECTIVITY ; ANTI-CORRELATED NETWORKS ; STATE BRAIN NETWORKS ; RESTING-STATE ; MODE NETWORK ; STRUCTURAL CONNECTIVITY ; PREFRONTAL CORTEX ; CEREBRAL-CORTEX ; ANTICORRELATED NETWORKS ; COGNITIVE STATES
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26033
Collection中国科学院行为科学重点实验室
Affiliation1.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
4.UCL, Wellcome Trust Ctr Neuroimaging, Queen Sq, London WC1N 3BG, England
5.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
6.Monash Univ, Monash Biomed Imaging, Clayton, Vic 3800, Australia
7.Monash Univ, Monash Inst Cognit & Clin Neurosci, Clayton, Vic 3800, Australia
8.NED Univ Engn & Technol, Dept Elect Engn, Karachi 75270, Pakistan
Recommended Citation
GB/T 7714
Zhou, Yuan,Friston, Karl J.,Zeidman, Peter,et al. The Hierarchical Organization of the Default, Dorsal Attention and Salience Networks in Adolescents and Young Adults[J]. CEREBRAL CORTEX,2018,28(2):726-737.
APA Zhou, Yuan,Friston, Karl J.,Zeidman, Peter,Chen, Jie,Li, Shu,&Razi, Adeel.(2018).The Hierarchical Organization of the Default, Dorsal Attention and Salience Networks in Adolescents and Young Adults.CEREBRAL CORTEX,28(2),726-737.
MLA Zhou, Yuan,et al."The Hierarchical Organization of the Default, Dorsal Attention and Salience Networks in Adolescents and Young Adults".CEREBRAL CORTEX 28.2(2018):726-737.
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