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Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study
Li, Zhi1,2; Huang, Jia1,2; Xu, Ting3,4; Wang, Ya1,2; Li, Ke5; Zeng, Ya-Wei5; Lui, Simon S. Y.1,6; Cheung, Eric F. C.6; Jin, Zhen5; Dazzan, Paola7,8,9; Glahn, David C.10,11; Chan, Raymond C. K.1,2
2018-03-01
发表期刊HUMAN BRAIN MAPPING
ISSN1065-9471
文章类型Article
卷号39期号:3页码:1438-1448
摘要Complex motor sequencing and sensory integration are two key items in scales assessing neurological soft signs. However, the underlying neural mechanism and heritability of these two functions is not known. Using a healthy twin design, we adopted two functional brain imaging tasks focusing on fist-edge-palm (FEP) complex motor sequence and audiovisual integration (AVI). Fifty-six monozygotic twins and 56 dizygotic twins were recruited in this study. The pre- and postcentral, temporal and parietal gyri, the supplementary motor area, and the cerebellum were activated during the FEP motor sequence, whereas the precentral, temporal, and fusiform gyri, the thalamus, and the caudate were activated during AVI. Activation in the supplementary motor area during FEP motor sequence and activation in the precentral gyrus and the thalamic nuclei during AVI exhibited significant heritability estimates, ranging from 0.5 to 0.62. These results suggest that activation in cortical motor areas, the thalamus and the cerebellum associated with complex motor sequencing and audiovisual integration function may be heritable.
关键词audiovisual integration fist-edge-palm fMRI healthy twin heritability
DOI10.1002/hbm.23935
收录类别SCI ; SSCI
语种英语
项目资助者Beijing Municipal Science & Technology Commission Grant(Z161100000216138) ; National Key Research and Development Programme(2016YFC0906402) ; Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Chinese Academy of Sciences(XDB02030002) ; Outstanding Young Investigator Award of the National Science Fund China(81088001) ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000424804400029
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]NEUROLOGICAL SOFT SIGNS ; POSTERIOR PARIETAL CORTEX ; 1ST-EPISODE SCHIZOPHRENIA ; FUNCTIONAL CONNECTIVITY ; CEREBELLAR VOLUME ; HUMAN BRAIN ; ABNORMALITIES ; MOVEMENTS ; THALAMUS ; ADULTS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26041
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
4.Child Mind Inst, Ctr Developing Brain, New York, NY USA
5.Hosp 306, MRI Ctr, Beijing, Peoples R China
6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
7.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
8.South London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res NIHR Biomed Res Ctr, London, England
9.Kings Coll London, London, England
10.Yale Univ, Dept Psychiat, New Haven, CT 06520 USA
11.Olin Neuropsychiat Res Ctr, Inst Living, Hartford, CT USA
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GB/T 7714
Li, Zhi,Huang, Jia,Xu, Ting,et al. Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study[J]. HUMAN BRAIN MAPPING,2018,39(3):1438-1448.
APA Li, Zhi.,Huang, Jia.,Xu, Ting.,Wang, Ya.,Li, Ke.,...&Chan, Raymond C. K..(2018).Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study.HUMAN BRAIN MAPPING,39(3),1438-1448.
MLA Li, Zhi,et al."Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study".HUMAN BRAIN MAPPING 39.3(2018):1438-1448.
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