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Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study
Li, Zhi1,2; Huang, Jia1,2; Xu, Ting3,4; Wang, Ya1,2; Li, Ke5; Zeng, Ya-Wei5; Lui, Simon S. Y.1,6; Cheung, Eric F. C.6; Jin, Zhen5; Dazzan, Paola7,8,9; Glahn, David C.10,11; Chan, Raymond C. K.1,2
First AuthorLi, Zhi
2018-03-01
Source PublicationHUMAN BRAIN MAPPING
Correspondent Emailrckchan@psych.ac.cn
ISSN1065-9471
SubtypeArticle
Volume39Issue:3Pages:1438-1448
Contribution Rank1
Abstract

Complex motor sequencing and sensory integration are two key items in scales assessing neurological soft signs. However, the underlying neural mechanism and heritability of these two functions is not known. Using a healthy twin design, we adopted two functional brain imaging tasks focusing on fist-edge-palm (FEP) complex motor sequence and audiovisual integration (AVI). Fifty-six monozygotic twins and 56 dizygotic twins were recruited in this study. The pre- and postcentral, temporal and parietal gyri, the supplementary motor area, and the cerebellum were activated during the FEP motor sequence, whereas the precentral, temporal, and fusiform gyri, the thalamus, and the caudate were activated during AVI. Activation in the supplementary motor area during FEP motor sequence and activation in the precentral gyrus and the thalamic nuclei during AVI exhibited significant heritability estimates, ranging from 0.5 to 0.62. These results suggest that activation in cortical motor areas, the thalamus and the cerebellum associated with complex motor sequencing and audiovisual integration function may be heritable.

KeywordAudiovisual Integration Fist-edge-palm Fmri Healthy Twin Heritability
DOI10.1002/hbm.23935
Indexed BySCI ; SSCI ; SSCI
Language英语
Funding OrganizationBeijing Municipal Science & Technology Commission Grant(Z161100000216138) ; National Key Research and Development Programme(2016YFC0906402) ; Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Chinese Academy of Sciences(XDB02030002) ; Outstanding Young Investigator Award of the National Science Fund China(81088001) ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000424804400029
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordNeurological Soft Signs ; Posterior Parietal Cortex ; 1st-episode Schizophrenia ; Functional Connectivity ; Cerebellar Volume ; Human Brain ; Abnormalities ; Movements ; Thalamus ; Adults
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26041
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
4.Child Mind Inst, Ctr Developing Brain, New York, NY USA
5.Hosp 306, MRI Ctr, Beijing, Peoples R China
6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
7.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
8.South London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res NIHR Biomed Res Ctr, London, England
9.Kings Coll London, London, England
10.Yale Univ, Dept Psychiat, New Haven, CT 06520 USA
11.Olin Neuropsychiat Res Ctr, Inst Living, Hartford, CT USA
Recommended Citation
GB/T 7714
Li, Zhi,Huang, Jia,Xu, Ting,et al. Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study[J]. HUMAN BRAIN MAPPING,2018,39(3):1438-1448.
APA Li, Zhi.,Huang, Jia.,Xu, Ting.,Wang, Ya.,Li, Ke.,...&Chan, Raymond C. K..(2018).Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study.HUMAN BRAIN MAPPING,39(3),1438-1448.
MLA Li, Zhi,et al."Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study".HUMAN BRAIN MAPPING 39.3(2018):1438-1448.
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