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Altered intrinsic and extrinsic connectivity in schizophrenia
Zhou, Yuan1,2,3,4; Zeidman, Peter4; Wu, Shihao5; Razi, Adeel4,6; Chen, Cheng5; Yang, Liuqing1,3; Zou, Jilin5; Wang, Gaohua5; Wang, Huiling5,7; Friston, Karl J.4; Y. Zhou; H. Wang
2018
Source PublicationNEUROIMAGE-CLINICAL
Correspondent Emailzhouyuan@psych.ac.cn ; hlwang@whu.edu.cn
ISSN2213-1582
SubtypeArticle
Volume17Pages:704-716
Contribution Rank1,2
Abstract

Schizophrenia is a disorder characterized by functional dysconnectivity among distributed brain regions. However, it is unclear how causal influences among large-scale brain networks are disrupted in schizophrenia. In this study, we used dynamic causal modeling (DCM) to assess the hypothesis that there is aberrant directed (effective) connectivity within and between three key large-scale brain networks (the dorsal attention network, the salience network and the default mode network) in schizophrenia during a working memory task. Functional MRI data during an n-back task from 40 patients with schizophrenia and 62 healthy controls were analyzed. Using hierarchical modeling of between-subject effects in DCM with Parametric Empirical Bayes, we found that intrinsic (within-region) and extrinsic (between-region) effective connectivity involving prefrontal regions were abnormal in schizophrenia. Specifically, in patients (i) inhibitory self-connections in prefrontal regions of the dorsal attention network were decreased across task conditions; (ii) extrinsic connectivity between regions of the default mode network was increased; specifically, from posterior cingulate cortex to the medial prefrontal cortex; (iii) between-network extrinsic connections involving the prefrontal cortex were altered; (iv) connections within networks and between networks were correlated with the severity of clinical symptoms and impaired cognition beyond working memory. In short, this study revealed the predominance of reduced synaptic efficacy of prefrontal efferents and afferents in the pathophysiology of schizophrenia.

KeywordDynamic causal modeling Effective connectivity Functional dysconnectivity Schizophrenia Working memory
DOI10.1016/j.nicl.2017.12.006
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(91132301 ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2012075) ; China Scholarship Council(201504910067) ; Wellcome Trust Principal Research Fellowship(088130/Z/09/Z) ; 91432302 ; 81371476)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000426180300074
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordNMDA RECEPTOR HYPOFUNCTION ; WORKING-MEMORY DYSFUNCTION ; DEFAULT MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; PARVALBUMIN INTERNEURONS ; COGNITIVE IMPAIRMENT ; PREFRONTAL CORTEX ; HEAD MOTION ; HUMAN BRAIN ; METAANALYSIS
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26042
Collection中国科学院行为科学重点实验室
Corresponding AuthorY. Zhou; H. Wang
Affiliation1.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
4.UCL, Wellcome Trust Ctr Neuroimaging, Queen Sq, London WC1N 3BG, England
5.Wuhan Univ, Renmin Hosp, Dept Psychiat, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China
6.NED Univ Engn & Technol, Dept Elect Engn, Karachi, Pakistan
7.Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Yuan,Zeidman, Peter,Wu, Shihao,et al. Altered intrinsic and extrinsic connectivity in schizophrenia[J]. NEUROIMAGE-CLINICAL,2018,17:704-716.
APA Zhou, Yuan.,Zeidman, Peter.,Wu, Shihao.,Razi, Adeel.,Chen, Cheng.,...&H. Wang.(2018).Altered intrinsic and extrinsic connectivity in schizophrenia.NEUROIMAGE-CLINICAL,17,704-716.
MLA Zhou, Yuan,et al."Altered intrinsic and extrinsic connectivity in schizophrenia".NEUROIMAGE-CLINICAL 17(2018):704-716.
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