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Altered intrinsic and extrinsic connectivity in schizophrenia
Zhou, Yuan1,2,3,4; Zeidman, Peter4; Wu, Shihao5; Razi, Adeel4,6; Chen, Cheng5; Yang, Liuqing1,3; Zou, Jilin5; Wang, Gaohua5; Wang, Huiling5,7; Friston, Karl J.4; Y. Zhou; H. Wang
2018
发表期刊NEUROIMAGE-CLINICAL
通讯作者邮箱zhouyuan@psych.ac.cn ; hlwang@whu.edu.cn
ISSN2213-1582
文章类型Article
卷号17页码:704-716
产权排序1,2
摘要

Schizophrenia is a disorder characterized by functional dysconnectivity among distributed brain regions. However, it is unclear how causal influences among large-scale brain networks are disrupted in schizophrenia. In this study, we used dynamic causal modeling (DCM) to assess the hypothesis that there is aberrant directed (effective) connectivity within and between three key large-scale brain networks (the dorsal attention network, the salience network and the default mode network) in schizophrenia during a working memory task. Functional MRI data during an n-back task from 40 patients with schizophrenia and 62 healthy controls were analyzed. Using hierarchical modeling of between-subject effects in DCM with Parametric Empirical Bayes, we found that intrinsic (within-region) and extrinsic (between-region) effective connectivity involving prefrontal regions were abnormal in schizophrenia. Specifically, in patients (i) inhibitory self-connections in prefrontal regions of the dorsal attention network were decreased across task conditions; (ii) extrinsic connectivity between regions of the default mode network was increased; specifically, from posterior cingulate cortex to the medial prefrontal cortex; (iii) between-network extrinsic connections involving the prefrontal cortex were altered; (iv) connections within networks and between networks were correlated with the severity of clinical symptoms and impaired cognition beyond working memory. In short, this study revealed the predominance of reduced synaptic efficacy of prefrontal efferents and afferents in the pathophysiology of schizophrenia.

关键词Dynamic causal modeling Effective connectivity Functional dysconnectivity Schizophrenia Working memory
DOI10.1016/j.nicl.2017.12.006
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(91132301 ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2012075) ; China Scholarship Council(201504910067) ; Wellcome Trust Principal Research Fellowship(088130/Z/09/Z) ; 91432302 ; 81371476)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000426180300074
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]NMDA RECEPTOR HYPOFUNCTION ; WORKING-MEMORY DYSFUNCTION ; DEFAULT MODE NETWORK ; FUNCTIONAL CONNECTIVITY ; PARVALBUMIN INTERNEURONS ; COGNITIVE IMPAIRMENT ; PREFRONTAL CORTEX ; HEAD MOTION ; HUMAN BRAIN ; METAANALYSIS
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26042
专题中国科学院行为科学重点实验室
通讯作者Y. Zhou; H. Wang
作者单位1.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
4.UCL, Wellcome Trust Ctr Neuroimaging, Queen Sq, London WC1N 3BG, England
5.Wuhan Univ, Renmin Hosp, Dept Psychiat, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China
6.NED Univ Engn & Technol, Dept Elect Engn, Karachi, Pakistan
7.Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Hubei, Peoples R China
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GB/T 7714
Zhou, Yuan,Zeidman, Peter,Wu, Shihao,et al. Altered intrinsic and extrinsic connectivity in schizophrenia[J]. NEUROIMAGE-CLINICAL,2018,17:704-716.
APA Zhou, Yuan.,Zeidman, Peter.,Wu, Shihao.,Razi, Adeel.,Chen, Cheng.,...&H. Wang.(2018).Altered intrinsic and extrinsic connectivity in schizophrenia.NEUROIMAGE-CLINICAL,17,704-716.
MLA Zhou, Yuan,et al."Altered intrinsic and extrinsic connectivity in schizophrenia".NEUROIMAGE-CLINICAL 17(2018):704-716.
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