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DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder
Fan, Zili1,2; Qian, Ying1,2; Lu, Qing1,2; Wang, Yufeng1,2; Chang, Suhua3,4; Yang, Li1,2
2018-02-01
Source PublicationBRAIN AND BEHAVIOR
Correspondent Emailyangli_pkuimh@bjmu.edu.cn
ISSN2162-3279
SubtypeArticle
Volume8Issue:2Pages:1-8
Contribution Rank3
Abstract

   Objective: To explore the association of DLGAP1 gene with executive function (EF) in attention deficit hyperactivity disorder (ADHD) children.
Method: A total of 763 ADHD children and 140 healthy controls were enrolled. The difference of EF between ADHD and controls was analyzed using the analysis of covariance (ANCOVA), with IQ, sex, and age as covariates. Both the associations of SNPs with EF and three symptom traits of ADHD were conducted using an additive linear regression model by PLINK with the same covariates as ANCOVA.
    Results: Compared with controls, children with ADHD showed poorer cognitive flexibility and inhibition. Two SNPs (rs2049161, p-value=5.08e-7, adjusted p-value=1.63e-4, rs16946051, p-value=5.18e-7, adjusted p-value=1.66e-4) survived multiple tests in Trail Making Test. Both SNPs also showed association with TOH (rs2049161, p=6.82e-4, rs16946051, p=7.91e-4). Set-based analysis for gene DLGAP1 and its functional pathway DLGAP1-DLG4-NMDA showed they were associated with cognitive flexibility at both gene (p=.0057) and pathway level (p=.0321). Furthermore, the gene and pathway also showed association with ADHD symptom score. The associated SNPs and their LD proxies were related to the expression of DLGAP1 in medulla and frontal cortex.
    Conclusion: Children with ADHD showed deficit in EF, especially, cognitive flexibility and inhibition. DLGAP1 was associated with cognitive flexibility and plan, and the role of DLGAP1 might be implemented through the complex of DLGAP1-DLG4-NMDA.

KeywordADHD cognitive flexibility DLGAP1 executive function NMDA
DOI10.1002/brb3.914
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Development Program of China(2014CB846104) ; National Natural Science Foundation of China(31401139 ; Beijing Municipal Science & Technology Commission(Z151100003915122) ; Sanming Project of Medicine in Shenzhen for "the ADHD Research Group from Peking University Sixth Hospital"(SZSM201612036) ; 81671358)
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000425508600020
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordGENOME-WIDE ASSOCIATION ; PREFRONTAL CORTEX ; INDIVIDUAL-DIFFERENCES ; COGNITIVE FLEXIBILITY ; DORSAL STRIATUM ; RESPONSE-INHIBITION ; MAJOR DEPRESSION ; WORKING-MEMORY ; EXPRESSION ; SCHIZOPHRENIA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26043
Collection中国科学院心理健康重点实验室
Affiliation1.Peking Univ, Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China
3.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Fan, Zili,Qian, Ying,Lu, Qing,et al. DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder[J]. BRAIN AND BEHAVIOR,2018,8(2):1-8.
APA Fan, Zili,Qian, Ying,Lu, Qing,Wang, Yufeng,Chang, Suhua,&Yang, Li.(2018).DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder.BRAIN AND BEHAVIOR,8(2),1-8.
MLA Fan, Zili,et al."DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder".BRAIN AND BEHAVIOR 8.2(2018):1-8.
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