In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study

doi:10.1016/j.schres.2017.07.021

	In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study
	Chiu, P. W.1,2; Lui, Simon S. Y.3,4; Hung, Karen S. Y.3; Chan, Raymond C. K.4,5,6 ; Chan, Queenie 7; Shamb, P. C.2,6; Cheung, Eric F. C.3; Mak, Henry K. F.1,2,8; H.K.F. Mak
通讯作者邮箱	makkf@hku.hk (h.k.f. mak).
心理所单位排序	4
摘要	Background: Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic neurons. In this study, levels of GABA, Glx (summation of glutamate and glutamine), and other metabolites in the anterior cingulate cortex were measured and compared between first-episode schizophrenia subjects and healthy controls (HC). Diagnostic potential of GABA and Glx as upstream biomarkers for schizophrenia was explored.
关键词	Gamma-aminobutyric acid Glutamate First-episode schizophrenia Proton magnetic resonance spectroscopy Biomarker Anterior cingulate cortex
	2018-03-01
语种	英语
DOI	10.1016/j.schres.2017.07.021
发表期刊	SCHIZOPHRENIA RESEARCH
ISSN	0920-9964
卷号	193 页码:295-303
期刊论文类型	Article
收录类别	SCI ; SSCI
WOS关键词	ANTERIOR CINGULATE CORTEX ; PREFRONTAL CORTEX ; GABA CONCENTRATION ; BIPOLAR DISORDER ; TISSUE SEGMENTATION ; MEDICATED PATIENTS ; POSTMORTEM-BRAIN ; GENE-EXPRESSION ; VISUAL-CORTEX ; FRONTAL LOBES
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000427784100047
资助机构	University of Hong Kong(201511159189) ; Philip KH Wong Foundation ; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong ; Beijing Municipal Science & Technology Commission Grant(Z161100000216138) ; Beijing Training Project for Leading Talents in ST(Z151100000315020) ; National Basic Research Programme of China(2016YFC0906402)
引用统计	被引频次：39[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/26054
专题	中国科学院心理健康重点实验室
通讯作者	H.K.F. Mak
作者单位	1.Univ Hong Kong, Dept Diagnost Radiol, Hong Kong, Hong Kong, Peoples R China 2.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China 3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China 7.Philips Healthcare Hong Kong, Hong Kong, Hong Kong, Peoples R China 8.Univ Hong Kong, Alzheimers Dis Res Network, Hong Kong, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Chiu, P. W.,Lui, Simon S. Y.,Hung, Karen S. Y.,et al. In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study[J]. SCHIZOPHRENIA RESEARCH,2018,193:295-303.
APA	Chiu, P. W..,Lui, Simon S. Y..,Hung, Karen S. Y..,Chan, Raymond C. K..,Chan, Queenie.,...&H.K.F. Mak.(2018).In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study.SCHIZOPHRENIA RESEARCH,193,295-303.
MLA	Chiu, P. W.,et al."In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study".SCHIZOPHRENIA RESEARCH 193(2018):295-303.

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