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In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study
Chiu, P. W.1,2; Lui, Simon S. Y.3,4; Hung, Karen S. Y.3; Chan, Raymond C. K.4,5,6; Chan, Queenie7; Shamb, P. C.2,6; Cheung, Eric F. C.3; Mak, Henry K. F.1,2,8; H.K.F. Mak
2018-03-01
发表期刊SCHIZOPHRENIA RESEARCH
通讯作者邮箱makkf@hku.hk (h.k.f. mak).
ISSN0920-9964
文章类型Article
卷号193页码:295-303
产权排序4
摘要

Background: Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic neurons. In this study, levels of GABA, Glx (summation of glutamate and glutamine), and other metabolites in the anterior cingulate cortex were measured and compared between first-episode schizophrenia subjects and healthy controls (HC). Diagnostic potential of GABA and Glx as upstream biomarkers for schizophrenia was explored.

关键词Gamma-aminobutyric acid Glutamate First-episode schizophrenia Proton magnetic resonance spectroscopy Biomarker Anterior cingulate cortex
DOI10.1016/j.schres.2017.07.021
收录类别SCI ; SSCI
语种英语
项目资助者University of Hong Kong(201511159189) ; Philip KH Wong Foundation ; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong ; Beijing Municipal Science & Technology Commission Grant(Z161100000216138) ; Beijing Training Project for Leading Talents in ST(Z151100000315020) ; National Basic Research Programme of China(2016YFC0906402)
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000427784100047
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ANTERIOR CINGULATE CORTEX ; PREFRONTAL CORTEX ; GABA CONCENTRATION ; BIPOLAR DISORDER ; TISSUE SEGMENTATION ; MEDICATED PATIENTS ; POSTMORTEM-BRAIN ; GENE-EXPRESSION ; VISUAL-CORTEX ; FRONTAL LOBES
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26054
专题中国科学院心理健康重点实验室
通讯作者H.K.F. Mak
作者单位1.Univ Hong Kong, Dept Diagnost Radiol, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China
3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
7.Philips Healthcare Hong Kong, Hong Kong, Hong Kong, Peoples R China
8.Univ Hong Kong, Alzheimers Dis Res Network, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Chiu, P. W.,Lui, Simon S. Y.,Hung, Karen S. Y.,et al. In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study[J]. SCHIZOPHRENIA RESEARCH,2018,193:295-303.
APA Chiu, P. W..,Lui, Simon S. Y..,Hung, Karen S. Y..,Chan, Raymond C. K..,Chan, Queenie.,...&H.K.F. Mak.(2018).In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study.SCHIZOPHRENIA RESEARCH,193,295-303.
MLA Chiu, P. W.,et al."In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study".SCHIZOPHRENIA RESEARCH 193(2018):295-303.
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