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In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study
Chiu, P. W.1,2; Lui, Simon S. Y.3,4; Hung, Karen S. Y.3; Chan, Raymond C. K.4,5,6; Chan, Queenie7; Shamb, P. C.2,6; Cheung, Eric F. C.3; Mak, Henry K. F.1,2,8; H.K.F. Mak
2018-03-01
Source PublicationSCHIZOPHRENIA RESEARCH
Correspondent Emailmakkf@hku.hk (h.k.f. mak).
ISSN0920-9964
SubtypeArticle
Volume193Pages:295-303
Contribution Rank4
Abstract

Background: Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic neurons. In this study, levels of GABA, Glx (summation of glutamate and glutamine), and other metabolites in the anterior cingulate cortex were measured and compared between first-episode schizophrenia subjects and healthy controls (HC). Diagnostic potential of GABA and Glx as upstream biomarkers for schizophrenia was explored.

KeywordGamma-aminobutyric acid Glutamate First-episode schizophrenia Proton magnetic resonance spectroscopy Biomarker Anterior cingulate cortex
DOI10.1016/j.schres.2017.07.021
Indexed BySCI ; SSCI
Language英语
Funding OrganizationUniversity of Hong Kong(201511159189) ; Philip KH Wong Foundation ; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong ; Beijing Municipal Science & Technology Commission Grant(Z161100000216138) ; Beijing Training Project for Leading Talents in ST(Z151100000315020) ; National Basic Research Programme of China(2016YFC0906402)
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000427784100047
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordANTERIOR CINGULATE CORTEX ; PREFRONTAL CORTEX ; GABA CONCENTRATION ; BIPOLAR DISORDER ; TISSUE SEGMENTATION ; MEDICATED PATIENTS ; POSTMORTEM-BRAIN ; GENE-EXPRESSION ; VISUAL-CORTEX ; FRONTAL LOBES
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26054
Collection中国科学院心理健康重点实验室
Corresponding AuthorH.K.F. Mak
Affiliation1.Univ Hong Kong, Dept Diagnost Radiol, Hong Kong, Hong Kong, Peoples R China
2.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China
3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
7.Philips Healthcare Hong Kong, Hong Kong, Hong Kong, Peoples R China
8.Univ Hong Kong, Alzheimers Dis Res Network, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Chiu, P. W.,Lui, Simon S. Y.,Hung, Karen S. Y.,et al. In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study[J]. SCHIZOPHRENIA RESEARCH,2018,193:295-303.
APA Chiu, P. W..,Lui, Simon S. Y..,Hung, Karen S. Y..,Chan, Raymond C. K..,Chan, Queenie.,...&H.K.F. Mak.(2018).In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study.SCHIZOPHRENIA RESEARCH,193,295-303.
MLA Chiu, P. W.,et al."In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study".SCHIZOPHRENIA RESEARCH 193(2018):295-303.
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