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| In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study | |
Chiu, P. W.1,2; Lui, Simon S. Y.3,4; Hung, Karen S. Y.3; Chan, Raymond C. K.4,5,6 ; Chan, Queenie7; Shamb, P. C.2,6; Cheung, Eric F. C.3; Mak, Henry K. F.1,2,8; H.K.F. Mak
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| Correspondent Email | makkf@hku.hk (h.k.f. mak). |
| Contribution Rank | 4 |
| Abstract | Background: Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic neurons. In this study, levels of GABA, Glx (summation of glutamate and glutamine), and other metabolites in the anterior cingulate cortex were measured and compared between first-episode schizophrenia subjects and healthy controls (HC). Diagnostic potential of GABA and Glx as upstream biomarkers for schizophrenia was explored. |
| Keyword | Gamma-aminobutyric acid Glutamate First-episode schizophrenia Proton magnetic resonance spectroscopy Biomarker Anterior cingulate cortex |
| 2018-03-01 | |
| Language | 英语 |
| DOI | 10.1016/j.schres.2017.07.021 |
| Source Publication | SCHIZOPHRENIA RESEARCH
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| ISSN | 0920-9964 |
| Volume | 193Pages:295-303 |
| Subtype | Article |
| Indexed By | SCI ; SSCI |
| WOS Keyword | ANTERIOR CINGULATE CORTEX ; PREFRONTAL CORTEX ; GABA CONCENTRATION ; BIPOLAR DISORDER ; TISSUE SEGMENTATION ; MEDICATED PATIENTS ; POSTMORTEM-BRAIN ; GENE-EXPRESSION ; VISUAL-CORTEX ; FRONTAL LOBES |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine |
| WOS Research Area | Psychiatry |
| WOS Subject | Psychiatry |
| WOS ID | WOS:000427784100047 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/26054 |
| Collection | 中国科学院心理健康重点实验室 |
| Corresponding Author | H.K.F. Mak |
| Affiliation | 1.Univ Hong Kong, Dept Diagnost Radiol, Hong Kong, Hong Kong, Peoples R China 2.Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China 3.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 6.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China 7.Philips Healthcare Hong Kong, Hong Kong, Hong Kong, Peoples R China 8.Univ Hong Kong, Alzheimers Dis Res Network, Hong Kong, Hong Kong, Peoples R China |
| Recommended Citation GB/T 7714 | Chiu, P. W.,Lui, Simon S. Y.,Hung, Karen S. Y.,et al. In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study[J]. SCHIZOPHRENIA RESEARCH,2018,193:295-303. |
| APA | Chiu, P. W..,Lui, Simon S. Y..,Hung, Karen S. Y..,Chan, Raymond C. K..,Chan, Queenie.,...&H.K.F. Mak.(2018).In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study.SCHIZOPHRENIA RESEARCH,193,295-303. |
| MLA | Chiu, P. W.,et al."In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study".SCHIZOPHRENIA RESEARCH 193(2018):295-303. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| In vivo gamma-aminob（970KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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