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Presumed structural and functional neural recovery after long-term abstinence from cocaine in male military veterans
He, Qinghua1,2,3,4,5,6,7; Huang, Xiaolu1; Turel, Ofir2,3,8; Schulte, Marya4; Huang, David4; Thames, April4; Bechara, Antoine2,3; Hser, Yih-Ing4
2018-06-08
发表期刊PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
文章类型Article
卷号84页码:18-29
产权排序6
摘要

Cumulative evidence suggests that cocaine use could alter the structure and function of different brain systems. However, the extent to which the altered brain structure and function possibly recover over time after cocaine abstinence remains less clear. The present study examines 39 male military veterans with different stages of cocaine addiction and long-term abstinence (from 1 year up to 30 years) and evaluates plausible changes in brain structure and function of specific brain regions that sub-serve addictions. These include the striatum that is involved in cocaine reward; the lateral prefrontal cortex (especially the dorsolateral PFC) that plays a major role in inhibitory control; the insula, which has been implicated in craving; and the medial orbitofrontal (OFC) and ventromedial prefrontal cortex (VMPFC) shown to play key roles in foresight and decision-making. The results suggest that there are differences in both brain structure (gray matter volume, GMV) and function between cocaine USERS and CONTROLS, with USERS showing plausible relative strengthening in neural systems for processing reward and craving, and relative weakening in neural systems involved in inhibitory control and decision-making. Examination of possible neural changes after abstinence suggests that presumed recovery occurs mostly in neural systems related to reward, craving, and inhibitory control, but to a lesser extent in neural systems related to decision-making. Given the limitations of the data in terms of a small sample size, as well as the lack of certainty about occasional use in the abstinent group, these results may be considered as preliminary. However, they are compelling in that they suggest that male military veterans cocaine USERS are indefinitely at a higher risk compared to CONTROLS for making lapses in judgment and decision-making leading to possible relapse, if reward salience and craving become more intense. Understanding the neurobiology of long-term cocaine abstinence in vulnerable populations and beyond could help devising better therapeutic strategies that prevent relapse.

关键词Cocaine addiction Functional connectivity fMRI VBM Abstinence
DOI10.1016/j.pnpbp.2018.01.024
收录类别SCI ; SSCI
语种英语
项目资助者National Institute on Drug Abuse (NIDA)(R03DA032542-01A1 ; National Natural Science Foundation of China(31400959) ; Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars(cx2017049) ; Fundamental Research Funds for the Central Universities(15XDSKD004) ; Open Research Fund of the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences(KLMH2015G01) ; Research Program Funds of the Collaborative Innovation Center of Assessment towards Basic Education Quality at Beijing Normal University(2016-06-014-BZK01) ; P30DA016383)
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000429000300003
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]GRAY-MATTER VOLUME ; VOXEL-BASED MORPHOMETRY ; HEROIN-DEPENDENT INDIVIDUALS ; INHIBITORY CONTROL PROCESSES ; MEDIAL ORBITOFRONTAL CORTEX ; DRUG-ADDICTION ; FORMER COCAINE ; TRAIT IMPULSIVITY ; PREFRONTAL CORTEX ; SMOKING CUES
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26068
专题中国科学院心理健康重点实验室
作者单位1.Southwest Univ, Fac Psychol, Chongqing 400715, Peoples R China
2.Univ Southern Calif, Brain & Creat Inst, Los Angeles, CA USA
3.Univ Southern Calif, Dept Psychol, Los Angeles, CA USA
4.Univ Calif Los Angeles, Integrated Subst Abuse Programs, Los Angeles, CA USA
5.Collaborat Innovat Ctr Assessment Basic Educ Qual, Southwest Univ Branch, Chongqing, Peoples R China
6.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
7.Chongqing Collaborat Innovat Ctr Brain Sci, Chongqing, Peoples R China
8.Calif State Univ Fullerton, Dept Informat Syst & Decis Sci, Fullerton, CA 92634 USA
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He, Qinghua,Huang, Xiaolu,Turel, Ofir,et al. Presumed structural and functional neural recovery after long-term abstinence from cocaine in male military veterans[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2018,84:18-29.
APA He, Qinghua.,Huang, Xiaolu.,Turel, Ofir.,Schulte, Marya.,Huang, David.,...&Hser, Yih-Ing.(2018).Presumed structural and functional neural recovery after long-term abstinence from cocaine in male military veterans.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,84,18-29.
MLA He, Qinghua,et al."Presumed structural and functional neural recovery after long-term abstinence from cocaine in male military veterans".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 84(2018):18-29.
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