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Neural responses during the anticipation and receipt of olfactory reward and punishment in human
Zou, Lai-quan1,2,3; Zhou, Han-yu2,3; Zhuang, Yuan3,4; van Hartevelt, Tim J.5,6,7,8; Lui, Simon S. Y.2,9; Cheung, Eric F. C.9; Moller, Arne6,7,8,10; Kringelbach, Morten L.5,6,7; Chan, Raymond C. K.2,3,10; R.C.K. Chan
2018-03-01
Source PublicationNEUROPSYCHOLOGIA
Correspondent Emailrckchan@psych.ac.cn
ISSN0028-3932
SubtypeArticle
Volume111Pages:172-179
Contribution Rank2,4
Abstract

Pleasure experience is an important part of normal healthy life and is essential for general and mental wellbeing. Many neuroimaging studies have investigated the underlying neural processing of verbal and visual modalities of reward. However, how the brain processes rewards in the olfactory modality is not fully understood. This study aimed to examine the neural basis of olfactory rewards in 25 healthy participants using functional magnetic resonance imaging (fMRI). We developed an Olfactory Incentive Delay (OLID) imaging task distinguishing between the anticipation and receipt of olfactory rewards and punishments. We found that the pallidum was activated during the anticipation of both olfactory rewards and punishments. The bilateral insula was activated independently from the odours' hedonic valence during the receipt phase. In addition, right caudate activation during the anticipation of unpleasant odours was correlated with self-reported anticipatory hedonic traits, whereas bilateral insular activation during the receipt of pleasant odours was correlated with self reported consummatory hedonic traits. These findings suggest that activity in the insula and the caudate may be biomarkers of anhedonia. These findings also highlight a useful and valid paradigm to study the neural circuitry underlying reward processing in people with anhedonia.

KeywordOlfactory Anticipation Hedonia Pallidum FMRI
DOI10.1016/j.neuropsychologia.2018.02.003
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Science Fund China(81571317 ; Beijing Municipal Science & Technology Commission(Z161100000216138) ; Beijing Training Project for the Leading Talents in S T(Z151100000315020) ; Chinese Academy of Science(XDB02030002) ; CAS Key Laboratory of Mental Health ; CAS/SAFEA International Partnership Programme for Creative Research Teams(Y2CX131003) ; Natural Science Foundation of Guangdong Province, China(2017A030310069) ; 31700963)
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS SubjectBehavioral Sciences ; Neurosciences ; Psychology, Experimental
WOS IDWOS:000430644300021
WOS HeadingsScience & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS KeywordLIKELIHOOD ESTIMATION METAANALYSIS ; EVENT-RELATED FMRI ; ORBITOFRONTAL CORTEX ; MONETARY REWARDS ; TRAIT ANHEDONIA ; PIRIFORM CORTEX ; PLEASANT ODORS ; HUMAN BRAIN ; ACTIVATION ; PLEASURE
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26073
Collection中国科学院心理健康重点实验室
Corresponding AuthorR.C.K. Chan
Affiliation1.Southern Med Univ, Sch Publ Hlth, Dept Psychol, Guangdong Prov Key Lab Trop Dis Res, Guangzhou, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
5.Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England
6.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark
7.Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
8.Aarhus Univ, CFIN, Aarhus, Denmark
9.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
10.Univ Chinese Acad Sci, Sino Danish Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zou, Lai-quan,Zhou, Han-yu,Zhuang, Yuan,et al. Neural responses during the anticipation and receipt of olfactory reward and punishment in human[J]. NEUROPSYCHOLOGIA,2018,111:172-179.
APA Zou, Lai-quan.,Zhou, Han-yu.,Zhuang, Yuan.,van Hartevelt, Tim J..,Lui, Simon S. Y..,...&R.C.K. Chan.(2018).Neural responses during the anticipation and receipt of olfactory reward and punishment in human.NEUROPSYCHOLOGIA,111,172-179.
MLA Zou, Lai-quan,et al."Neural responses during the anticipation and receipt of olfactory reward and punishment in human".NEUROPSYCHOLOGIA 111(2018):172-179.
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