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Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia
Fang, Xiaojing1; Wang, Yulin2; Cheng, Luqi1; Zhang, Yuanchao1; Zhou, Yuan3,4; Wu, Shihao5; Huang, Huan5; Zou, Jilin5; Chen, Cheng5; Chen, Jun6; Wang, Huiling5,7; Jiang, Tianzi1,8,9,10,11; Huiling Wang; Tianzi Jiang
2018-04-01
发表期刊BRAIN IMAGING AND BEHAVIOR
通讯作者邮箱hlwang@whu.edu.cn ; jiangtz@nlpr.ia.ac.cn
ISSN1931-7557
文章类型Article
卷号12期号:2页码:335-344
产权排序3
摘要

Working memory (WM) deficit is a core feature of schizophrenia and is characterized by abnormal functional integration in the prefrontal cortex, including the dorsolateral prefrontal cortex (dLPFC), dorsal anterior cingulate cortex (dACC), and ventrolateral prefrontal cortex (vLPFC). However, the specific mechanism by which the abnormal neuronal circuits that involve these brain regions contribute to this deficit is still unclear. Therefore, this study focused on these regions and sought to answer which abnormal causal relationships in these regions can be linked to impaired WM in schizophrenia. We used spectral dynamic causal modeling to estimate directed (effective) connectivity between these regions based on resting-state functional magnetic resonance imaging data from healthy control (HC) subjects and patients with first-episode schizophrenia (FES). By comparing these effective connections in the controls and patients, we found that the effective connectivity from the dACC to the dLPFC and from the right dLPFC to the left vLPFC was weaker in the FES group than in the HC group. Furthermore, these effective connections displayed a positive correlation with WM performance in the HCs. However, in the FES patients, the effective connectivity from the dACC to the dLPFC was not correlated with WM performance, and the effective connectivity from the right dLPFC to the left vLPFC was negatively correlated with WM performance. These results could be explained by an aberrant top-down mechanism of WM processing and provide new evidence for the dysconnectivity hypothesis of schizophrenia.

关键词Resting-state fMRI Effective connectivity Schizophrenia Spectral dynamic causal modeling Working memory deficit
DOI10.1007/s11682-017-9692-0
收录类别SCI ; SSCI
语种英语
项目资助者National Basic Research Program of China(2011CB707800) ; National Natural Science Foundation of China(91132301) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2012075) ; Plan A of Science and Technology Support Program from Science and Technology Department of Sichuan Province(2014SZ0014) ; Natural Science Foundation of Hubei Province(2014CFB732)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000429029000004
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ALTERED EFFECTIVE CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; COGNITIVE CONTROL ; SYNAPTIC PLASTICITY ; CORTEX ; FMRI ; NETWORK ; DISCONNECTION ; DYSFUNCTION ; ACTIVATION
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26077
专题中国科学院行为科学重点实验室
通讯作者Huiling Wang; Tianzi Jiang
作者单位1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Sichuan, Peoples R China
2.Vrije Univ Brussel, Fac Psychol & Educ Sci, Dept Expt & Appl Psychol, Res Grp Biol Psychol, Brussels, Belgium
3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
5.Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan, Hubei, Peoples R China
6.Wuhan Univ, Dept Radiol, Renmin Hosp, Wuhan, Hubei, Peoples R China
7.Hubei Prov Key Lab Dev Originated Dis, Wuhan, Hubei, Peoples R China
8.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
10.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China
11.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
推荐引用方式
GB/T 7714
Fang, Xiaojing,Wang, Yulin,Cheng, Luqi,et al. Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia[J]. BRAIN IMAGING AND BEHAVIOR,2018,12(2):335-344.
APA Fang, Xiaojing.,Wang, Yulin.,Cheng, Luqi.,Zhang, Yuanchao.,Zhou, Yuan.,...&Tianzi Jiang.(2018).Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia.BRAIN IMAGING AND BEHAVIOR,12(2),335-344.
MLA Fang, Xiaojing,et al."Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia".BRAIN IMAGING AND BEHAVIOR 12.2(2018):335-344.
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