PSYCH OpenIR  > 中国科学院心理健康重点实验室
Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors
Liu, Luobing1,2; Wang, Li1,2; Cao, Chengqi1,2; Cao, Xing1,2; Zhu, Ye1,2; Liu, Ping3; Luo, Shu3; Zhang, Jianxin1; Li Wang
2018
Source PublicationANXIETY STRESS AND COPING
Correspondent Emailwangli1@psych.ac.cn
ISSN1061-5806
SubtypeArticle
Volume31Issue:3Pages:318-327
Contribution Rank1
Abstract

Background and Objectives: Prior studies have found that the serotonin transporter gene-linked polymorphic region (5-HTTLPR) interacts with trauma exposure to increase general risk for Posttraumatic Stress Disorder (PTSD). However, there is little knowledge about the effects of the interaction on distinct symptom clusters of PTSD. This study aimed to investigate the relation between the interaction of 5-HTTLPR and earthquake-related exposures and a contemporary phenotypic model of DSM-5 PTSD symptoms in a traumatised adult sample from China.Design: A cross-sectional design with gene-environment interaction (GxE) approach was adopted. Methods: Participants were 1131 survivors who experienced 2008 Wenchuan earthquake. PTSD symptoms were assessed with the PTSD Checklist for DSM-5 (PCL-5). The 5-HTTLPR polymorphism was genotyped with capillary electrophoresis (CE) in ABI 3730xl genetic Analyzer.Results: Although there was no significant interaction between 5-HTTLPR and traumatic exposure on total PTSD symptoms, respondents with the LL genotype of 5-HTTLPR who were highly exposed to the earthquake experienced lower intrusion and avoidance symptoms than those with the S-allele carriers.Conclusions: The findings suggest that the 5-HTTLPR may have an important impact on the development of PTSD and add to the extant knowledge on understanding and treating of posttraumatic psychopathology.

KeywordDSM-5 5-HTTLPR genotype PTSD phenotypic models gene-environment interaction
DOI10.1080/10615806.2017.1420174
Indexed BySSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31271099 ; External Cooperation Program of Chinese Academy of Sciences(153111KYSB20160036) ; Chinese Academy of Sciences President's International Fellowship Initiative(2016VEA019) ; 31471004)
WOS Research AreaNeurosciences & Neurology ; Psychiatry ; Psychology
WOS SubjectNeurosciences ; Psychiatry ; Psychology, Multidisciplinary
WOS IDWOS:000428806800006
WOS HeadingsScience & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS KeywordNATIONAL COMORBIDITY SURVEY ; GENE X ENVIRONMENT ; DIMENSIONAL STRUCTURE ; EPIDEMIOLOGIC SAMPLE ; ANXIETY DISORDERS ; LATENT STRUCTURE ; PROMOTER-REGION ; DEPRESSION ; POLYMORPHISM ; ADOLESCENTS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26078
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi Wang
Affiliation1.Chinese Acad Sci, Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Peoples Hosp Deyang City, Deyang, Peoples R China
Recommended Citation
GB/T 7714
Liu, Luobing,Wang, Li,Cao, Chengqi,et al. Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors[J]. ANXIETY STRESS AND COPING,2018,31(3):318-327.
APA Liu, Luobing.,Wang, Li.,Cao, Chengqi.,Cao, Xing.,Zhu, Ye.,...&Li Wang.(2018).Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors.ANXIETY STRESS AND COPING,31(3),318-327.
MLA Liu, Luobing,et al."Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors".ANXIETY STRESS AND COPING 31.3(2018):318-327.
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