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Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors
Liu, Luobing1,2; Wang, Li1,2; Cao, Chengqi1,2; Cao, Xing1,2; Zhu, Ye1,2; Liu, Ping3; Luo, Shu3; Zhang, Jianxin1; Li Wang
2018
发表期刊ANXIETY STRESS AND COPING
通讯作者邮箱wangli1@psych.ac.cn
ISSN1061-5806
文章类型Article
卷号31期号:3页码:318-327
产权排序1
摘要

Background and Objectives: Prior studies have found that the serotonin transporter gene-linked polymorphic region (5-HTTLPR) interacts with trauma exposure to increase general risk for Posttraumatic Stress Disorder (PTSD). However, there is little knowledge about the effects of the interaction on distinct symptom clusters of PTSD. This study aimed to investigate the relation between the interaction of 5-HTTLPR and earthquake-related exposures and a contemporary phenotypic model of DSM-5 PTSD symptoms in a traumatised adult sample from China.Design: A cross-sectional design with gene-environment interaction (GxE) approach was adopted. Methods: Participants were 1131 survivors who experienced 2008 Wenchuan earthquake. PTSD symptoms were assessed with the PTSD Checklist for DSM-5 (PCL-5). The 5-HTTLPR polymorphism was genotyped with capillary electrophoresis (CE) in ABI 3730xl genetic Analyzer.Results: Although there was no significant interaction between 5-HTTLPR and traumatic exposure on total PTSD symptoms, respondents with the LL genotype of 5-HTTLPR who were highly exposed to the earthquake experienced lower intrusion and avoidance symptoms than those with the S-allele carriers.Conclusions: The findings suggest that the 5-HTTLPR may have an important impact on the development of PTSD and add to the extant knowledge on understanding and treating of posttraumatic psychopathology.

关键词DSM-5 5-HTTLPR genotype PTSD phenotypic models gene-environment interaction
DOI10.1080/10615806.2017.1420174
收录类别SSCI
语种英语
项目资助者National Natural Science Foundation of China(31271099 ; External Cooperation Program of Chinese Academy of Sciences(153111KYSB20160036) ; Chinese Academy of Sciences President's International Fellowship Initiative(2016VEA019) ; 31471004)
WOS研究方向Neurosciences & Neurology ; Psychiatry ; Psychology
WOS类目Neurosciences ; Psychiatry ; Psychology, Multidisciplinary
WOS记录号WOS:000428806800006
WOS标题词Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
关键词[WOS]NATIONAL COMORBIDITY SURVEY ; GENE X ENVIRONMENT ; DIMENSIONAL STRUCTURE ; EPIDEMIOLOGIC SAMPLE ; ANXIETY DISORDERS ; LATENT STRUCTURE ; PROMOTER-REGION ; DEPRESSION ; POLYMORPHISM ; ADOLESCENTS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26078
专题中国科学院心理健康重点实验室
通讯作者Li Wang
作者单位1.Chinese Acad Sci, Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Peoples Hosp Deyang City, Deyang, Peoples R China
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Liu, Luobing,Wang, Li,Cao, Chengqi,et al. Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors[J]. ANXIETY STRESS AND COPING,2018,31(3):318-327.
APA Liu, Luobing.,Wang, Li.,Cao, Chengqi.,Cao, Xing.,Zhu, Ye.,...&Li Wang.(2018).Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors.ANXIETY STRESS AND COPING,31(3),318-327.
MLA Liu, Luobing,et al."Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors".ANXIETY STRESS AND COPING 31.3(2018):318-327.
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