PSYCH OpenIR  > 中国科学院行为科学重点实验室
Reconfiguration of Cortical Networks in MDD Uncovered by Multiscale Community Detection with fMRI
He, Ye1; Lim, Sol1; Fortunato, Santo2,3; Sporns, Olaf1,3,4; Zhang, Lei5; Qiu, Jiang6; Xie, Peng7,8,9; Zuo, Xi-Nian5,10,11
2018-04-01
发表期刊CEREBRAL CORTEX
ISSN1047-3211
文章类型Article
卷号28期号:4页码:1383-1395
产权排序10,11
摘要

Major depressive disorder (MDD) is known to be associated with altered interactions between distributed brain regions. How these regional changes relate to the reorganization of cortical functional systems, and their modulation by antidepressant medication, is relatively unexplored. To identify changes in the community structure of cortical functional networks in MDD, we performed a multiscale community detection algorithm on resting-state functional connectivity networks of unmedicated MDD (uMDD) patients (n = 46), medicated MDD (mMDD) patients (n = 38), and healthy controls (n = 50), which yielded a spectrum of multiscale community partitions. we selected an optimal resolution level by identifying the most stable community partition for each group. uMDD and mMDD groups exhibited a similar reconfiguration of the community structure of the visual association and the default mode systems but showed different reconfiguration profiles in the frontoparietal control (FPC) subsystems. Furthermore, the central system (somatomotor/salience) and 3 frontoparietal subsystems showed strengthened connectivity with other communities in uMDD but, with the exception of 1 frontoparietal subsystem, returned to control levels in mMDD. These findings provide evidence for reconfiguration of specific cortical functional systems associated with MDD, as well as potential effects of medication in restoring disease-related network alterations, especially those of the FPC system.

关键词Antidepressant Functional Connectivity Graph Theory MDD Resting-state fMRI
DOI10.1093/cercor/bhx335
收录类别SCI
语种英语
项目资助者National Basic Research (973) Program(2015CB351702) ; Natural Science Foundation of China(NSFC 31271189 ; Beijing Municipal Science and Tech Commission(Z161100002616023 ; China - Netherlands CAS-NWO Programme(153111KYSB20160020) ; Major Project of National Social Science Foundation of China(14ZDB161) ; NSFC Major Joint Fund for International Cooperation and Exchange(81220108014) ; National Institutes of Health(R01AR009036) ; National R&D Infrastructure and Facility Development Program of China, "Fundamental Science Data Sharing Platform"(DKA2017-12-02-21) ; 81471740) ; Z171100000117012)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000428877200024
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]MAJOR DEPRESSIVE DISORDER ; STATE FUNCTIONAL CONNECTIVITY ; SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; FALSE DISCOVERY RATE ; BRAIN NETWORKS ; DEFAULT MODE ; ANTIDEPRESSANT TREATMENT ; INTRINSIC CONNECTIVITY ; STRUCTURAL NETWORKS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26087
专题中国科学院行为科学重点实验室
作者单位1.Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
2.Indiana Univ, Sch Informat & Comp, Bloomington, IN 47405 USA
3.Indiana Univ, Network Sci Inst, Bloomington, IN 47408 USA
4.Univ Chinese Acad Sci CAS, Dept Psychol, Beijing 100049, Peoples R China
5.Guangxi Teachers Educ Univ, Key Lab Brain & Educ Sci, Nanning 530001, Peoples R China
6.Southwest Univ, Fac Psychol, Chongqing 400715, Peoples R China
7.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China
8.Chongqing Key Lab Neurobiol, Chongqing 400016, Peoples R China
9.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China
10.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China
11.Inst Psychol, Res Ctr Lifespan Dev Mind & Brain, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
He, Ye,Lim, Sol,Fortunato, Santo,et al. Reconfiguration of Cortical Networks in MDD Uncovered by Multiscale Community Detection with fMRI[J]. CEREBRAL CORTEX,2018,28(4):1383-1395.
APA He, Ye.,Lim, Sol.,Fortunato, Santo.,Sporns, Olaf.,Zhang, Lei.,...&Zuo, Xi-Nian.(2018).Reconfiguration of Cortical Networks in MDD Uncovered by Multiscale Community Detection with fMRI.CEREBRAL CORTEX,28(4),1383-1395.
MLA He, Ye,et al."Reconfiguration of Cortical Networks in MDD Uncovered by Multiscale Community Detection with fMRI".CEREBRAL CORTEX 28.4(2018):1383-1395.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Reconfiguration of C(1173KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[He, Ye]的文章
[Lim, Sol]的文章
[Fortunato, Santo]的文章
百度学术
百度学术中相似的文章
[He, Ye]的文章
[Lim, Sol]的文章
[Fortunato, Santo]的文章
必应学术
必应学术中相似的文章
[He, Ye]的文章
[Lim, Sol]的文章
[Fortunato, Santo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。