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Reconfiguration of Cortical Networks in MDD Uncovered by Multiscale Community Detection with fMRI
He, Ye1; Lim, Sol1; Fortunato, Santo2,3; Sporns, Olaf1,3,4; Zhang, Lei5; Qiu, Jiang6; Xie, Peng7,8,9; Zuo, Xi-Nian5,10,11
2018-04-01
Source PublicationCEREBRAL CORTEX
ISSN1047-3211
SubtypeArticle
Volume28Issue:4Pages:1383-1395
Contribution Rank10,11
Abstract

Major depressive disorder (MDD) is known to be associated with altered interactions between distributed brain regions. How these regional changes relate to the reorganization of cortical functional systems, and their modulation by antidepressant medication, is relatively unexplored. To identify changes in the community structure of cortical functional networks in MDD, we performed a multiscale community detection algorithm on resting-state functional connectivity networks of unmedicated MDD (uMDD) patients (n = 46), medicated MDD (mMDD) patients (n = 38), and healthy controls (n = 50), which yielded a spectrum of multiscale community partitions. we selected an optimal resolution level by identifying the most stable community partition for each group. uMDD and mMDD groups exhibited a similar reconfiguration of the community structure of the visual association and the default mode systems but showed different reconfiguration profiles in the frontoparietal control (FPC) subsystems. Furthermore, the central system (somatomotor/salience) and 3 frontoparietal subsystems showed strengthened connectivity with other communities in uMDD but, with the exception of 1 frontoparietal subsystem, returned to control levels in mMDD. These findings provide evidence for reconfiguration of specific cortical functional systems associated with MDD, as well as potential effects of medication in restoring disease-related network alterations, especially those of the FPC system.

KeywordAntidepressant Functional Connectivity Graph Theory MDD Resting-state fMRI
DOI10.1093/cercor/bhx335
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research (973) Program(2015CB351702) ; Natural Science Foundation of China(NSFC 31271189 ; Beijing Municipal Science and Tech Commission(Z161100002616023 ; China - Netherlands CAS-NWO Programme(153111KYSB20160020) ; Major Project of National Social Science Foundation of China(14ZDB161) ; NSFC Major Joint Fund for International Cooperation and Exchange(81220108014) ; National Institutes of Health(R01AR009036) ; National R&D Infrastructure and Facility Development Program of China, "Fundamental Science Data Sharing Platform"(DKA2017-12-02-21) ; 81471740) ; Z171100000117012)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000428877200024
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordMAJOR DEPRESSIVE DISORDER ; STATE FUNCTIONAL CONNECTIVITY ; SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; FALSE DISCOVERY RATE ; BRAIN NETWORKS ; DEFAULT MODE ; ANTIDEPRESSANT TREATMENT ; INTRINSIC CONNECTIVITY ; STRUCTURAL NETWORKS
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26087
Collection中国科学院行为科学重点实验室
Affiliation1.Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA
2.Indiana Univ, Sch Informat & Comp, Bloomington, IN 47405 USA
3.Indiana Univ, Network Sci Inst, Bloomington, IN 47408 USA
4.Univ Chinese Acad Sci CAS, Dept Psychol, Beijing 100049, Peoples R China
5.Guangxi Teachers Educ Univ, Key Lab Brain & Educ Sci, Nanning 530001, Peoples R China
6.Southwest Univ, Fac Psychol, Chongqing 400715, Peoples R China
7.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China
8.Chongqing Key Lab Neurobiol, Chongqing 400016, Peoples R China
9.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China
10.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China
11.Inst Psychol, Res Ctr Lifespan Dev Mind & Brain, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
He, Ye,Lim, Sol,Fortunato, Santo,et al. Reconfiguration of Cortical Networks in MDD Uncovered by Multiscale Community Detection with fMRI[J]. CEREBRAL CORTEX,2018,28(4):1383-1395.
APA He, Ye.,Lim, Sol.,Fortunato, Santo.,Sporns, Olaf.,Zhang, Lei.,...&Zuo, Xi-Nian.(2018).Reconfiguration of Cortical Networks in MDD Uncovered by Multiscale Community Detection with fMRI.CEREBRAL CORTEX,28(4),1383-1395.
MLA He, Ye,et al."Reconfiguration of Cortical Networks in MDD Uncovered by Multiscale Community Detection with fMRI".CEREBRAL CORTEX 28.4(2018):1383-1395.
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