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Brain oscillations reflecting pain-related behavior in freely moving rats
Peng, Weiwei1; Xia, Xiaolei2,3,4; Yi, Ming5,6; Huang, Gan7; Zhang, Zhiguo7; Iannetti, Giandomenico8; Hu, Li2,3,4,8; L. Hu
2018
发表期刊PAIN
通讯作者邮箱huli@psych.ac.cn
ISSN0304-3959
文章类型Article
卷号159期号:1页码:106-118
产权排序2
摘要

Recording oscillatory brain activity holds great promise in pain research. However, experimental results are variable and often difficult to reconcile. Some of these inconsistencies arise from the use of hypothesis-driven analysis approaches that (1) do not assess the consistency of the observed responses within and across individuals, and (2) do not fully exploit information sampled across the entire cortex. Here, we address these issues by recording the electrocorticogram directly from the brain surface of 12 freely moving rats. Using a hypothesis-free approach, we isolated brain oscillations induced by graded nociceptive stimuli and characterized their relation to pain-related behavior. We isolated 4 responses, one phase-locked event-related potential, 2 non-phase-locked event-related synchronizations, and one non-phase-locked event-related desynchronization (ERD), in different frequency bands (delta/theta-ERD, theta/alpha-event-related synchronization, and gamma-band event-related synchronization). All responses except the delta/theta-ERD correlated with pain-related behavior at within-subject level. Notably, the gamma-band event-related synchronization was the only response that reliably correlated with pain-related behavior between subjects. These results comprehensively characterize the physiological properties of the brain oscillations elicited by nociceptive stimuli in freely moving rodents and provide a foundational work to improve the translation of experimental animal findings to human physiology and pathophysiology.

关键词Brain oscillations Pain Animal models Electrocorticography Gamma-band event-related synchronization (gamma-ERS)
DOI10.1097/j.pain.0000000000001069
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31500921 ; Chongqing Research Program of Basic Research and Frontier Technology(cstc2015jcyjBX0050) ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences(Y6CX021008) ; Wellcome Trust ; European Research Council ; Paris Institute for Advanced Studies (France) ; 31471082 ; 31671141)
WOS研究方向Anesthesiology ; Neurosciences & Neurology
WOS类目Anesthesiology ; Clinical Neurology ; Neurosciences
WOS记录号WOS:000428998800015
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]PRIMARY SOMATOSENSORY CORTEX ; LASER-EVOKED POTENTIALS ; MULTIPLE LINEAR-REGRESSION ; DIRECT-CURRENT STIMULATION ; EEG RESPONSES ; NOCICEPTIVE NEURONS ; STIMULUS SALIENCY ; FIELD POTENTIALS ; CONSCIOUS RATS ; C-FIBER
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26088
专题中国科学院心理健康重点实验室
通讯作者L. Hu
作者单位1.Shenzhen Univ, Coll Psychol & Sociol, Shenzhen, Peoples R China
2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
5.Peking Univ, Neurosci Res Inst, Minist Educ, Natl Hlth & Planning Commiss, Beijing, Peoples R China
6.Peking Univ, Key Lab Neurosci, Minist Educ, Natl Hlth & Planning Commiss, Beijing, Peoples R China
7.Shenzhen Univ, Sch Biomed Engn, Shenzhen, Peoples R China
8.UCL, Dept Neurosci Physiol & Pharmacol, London, England
推荐引用方式
GB/T 7714
Peng, Weiwei,Xia, Xiaolei,Yi, Ming,et al. Brain oscillations reflecting pain-related behavior in freely moving rats[J]. PAIN,2018,159(1):106-118.
APA Peng, Weiwei.,Xia, Xiaolei.,Yi, Ming.,Huang, Gan.,Zhang, Zhiguo.,...&L. Hu.(2018).Brain oscillations reflecting pain-related behavior in freely moving rats.PAIN,159(1),106-118.
MLA Peng, Weiwei,et al."Brain oscillations reflecting pain-related behavior in freely moving rats".PAIN 159.1(2018):106-118.
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