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Brain oscillations reflecting pain-related behavior in freely moving rats | |
Peng, Weiwei1; Xia, Xiaolei2,3,4; Yi, Ming5,6; Huang, Gan7; Zhang, Zhiguo7; Iannetti, Giandomenico8; Hu, Li2,3,4,8; L. Hu | |
通讯作者邮箱 | huli@psych.ac.cn |
心理所单位排序 | 2 |
摘要 | Recording oscillatory brain activity holds great promise in pain research. However, experimental results are variable and often difficult to reconcile. Some of these inconsistencies arise from the use of hypothesis-driven analysis approaches that (1) do not assess the consistency of the observed responses within and across individuals, and (2) do not fully exploit information sampled across the entire cortex. Here, we address these issues by recording the electrocorticogram directly from the brain surface of 12 freely moving rats. Using a hypothesis-free approach, we isolated brain oscillations induced by graded nociceptive stimuli and characterized their relation to pain-related behavior. We isolated 4 responses, one phase-locked event-related potential, 2 non-phase-locked event-related synchronizations, and one non-phase-locked event-related desynchronization (ERD), in different frequency bands (delta/theta-ERD, theta/alpha-event-related synchronization, and gamma-band event-related synchronization). All responses except the delta/theta-ERD correlated with pain-related behavior at within-subject level. Notably, the gamma-band event-related synchronization was the only response that reliably correlated with pain-related behavior between subjects. These results comprehensively characterize the physiological properties of the brain oscillations elicited by nociceptive stimuli in freely moving rodents and provide a foundational work to improve the translation of experimental animal findings to human physiology and pathophysiology. |
关键词 | Brain oscillations Pain Animal models Electrocorticography Gamma-band event-related synchronization (gamma-ERS) |
2018 | |
语种 | 英语 |
DOI | 10.1097/j.pain.0000000000001069 |
发表期刊 | PAIN |
ISSN | 0304-3959 |
卷号 | 159期号:1页码:106-118 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | PRIMARY SOMATOSENSORY CORTEX ; LASER-EVOKED POTENTIALS ; MULTIPLE LINEAR-REGRESSION ; DIRECT-CURRENT STIMULATION ; EEG RESPONSES ; NOCICEPTIVE NEURONS ; STIMULUS SALIENCY ; FIELD POTENTIALS ; CONSCIOUS RATS ; C-FIBER |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Anesthesiology ; Neurosciences & Neurology |
WOS类目 | Anesthesiology ; Clinical Neurology ; Neurosciences |
WOS记录号 | WOS:000428998800015 |
Q分类 | Q1 |
资助机构 | National Natural Science Foundation of China(31500921 ; Chongqing Research Program of Basic Research and Frontier Technology(cstc2015jcyjBX0050) ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences(Y6CX021008) ; Wellcome Trust ; European Research Council ; Paris Institute for Advanced Studies (France) ; 31471082 ; 31671141) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/26088 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | L. Hu |
作者单位 | 1.Shenzhen Univ, Coll Psychol & Sociol, Shenzhen, Peoples R China 2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Southwest Univ, Fac Psychol, Chongqing, Peoples R China 5.Peking Univ, Neurosci Res Inst, Minist Educ, Natl Hlth & Planning Commiss, Beijing, Peoples R China 6.Peking Univ, Key Lab Neurosci, Minist Educ, Natl Hlth & Planning Commiss, Beijing, Peoples R China 7.Shenzhen Univ, Sch Biomed Engn, Shenzhen, Peoples R China 8.UCL, Dept Neurosci Physiol & Pharmacol, London, England |
推荐引用方式 GB/T 7714 | Peng, Weiwei,Xia, Xiaolei,Yi, Ming,et al. Brain oscillations reflecting pain-related behavior in freely moving rats[J]. PAIN,2018,159(1):106-118. |
APA | Peng, Weiwei.,Xia, Xiaolei.,Yi, Ming.,Huang, Gan.,Zhang, Zhiguo.,...&L. Hu.(2018).Brain oscillations reflecting pain-related behavior in freely moving rats.PAIN,159(1),106-118. |
MLA | Peng, Weiwei,et al."Brain oscillations reflecting pain-related behavior in freely moving rats".PAIN 159.1(2018):106-118. |
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