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Brain oscillations reflecting pain-related behavior in freely moving rats
Peng, Weiwei1; Xia, Xiaolei2,3,4; Yi, Ming5,6; Huang, Gan7; Zhang, Zhiguo7; Iannetti, Giandomenico8; Hu, Li2,3,4,8; L. Hu
2018
Source PublicationPAIN
Correspondent Emailhuli@psych.ac.cn
ISSN0304-3959
SubtypeArticle
Volume159Issue:1Pages:106-118
Contribution Rank2
Abstract

Recording oscillatory brain activity holds great promise in pain research. However, experimental results are variable and often difficult to reconcile. Some of these inconsistencies arise from the use of hypothesis-driven analysis approaches that (1) do not assess the consistency of the observed responses within and across individuals, and (2) do not fully exploit information sampled across the entire cortex. Here, we address these issues by recording the electrocorticogram directly from the brain surface of 12 freely moving rats. Using a hypothesis-free approach, we isolated brain oscillations induced by graded nociceptive stimuli and characterized their relation to pain-related behavior. We isolated 4 responses, one phase-locked event-related potential, 2 non-phase-locked event-related synchronizations, and one non-phase-locked event-related desynchronization (ERD), in different frequency bands (delta/theta-ERD, theta/alpha-event-related synchronization, and gamma-band event-related synchronization). All responses except the delta/theta-ERD correlated with pain-related behavior at within-subject level. Notably, the gamma-band event-related synchronization was the only response that reliably correlated with pain-related behavior between subjects. These results comprehensively characterize the physiological properties of the brain oscillations elicited by nociceptive stimuli in freely moving rodents and provide a foundational work to improve the translation of experimental animal findings to human physiology and pathophysiology.

KeywordBrain oscillations Pain Animal models Electrocorticography Gamma-band event-related synchronization (gamma-ERS)
DOI10.1097/j.pain.0000000000001069
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(31500921 ; Chongqing Research Program of Basic Research and Frontier Technology(cstc2015jcyjBX0050) ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences(Y6CX021008) ; Wellcome Trust ; European Research Council ; Paris Institute for Advanced Studies (France) ; 31471082 ; 31671141)
WOS Research AreaAnesthesiology ; Neurosciences & Neurology
WOS SubjectAnesthesiology ; Clinical Neurology ; Neurosciences
WOS IDWOS:000428998800015
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordPRIMARY SOMATOSENSORY CORTEX ; LASER-EVOKED POTENTIALS ; MULTIPLE LINEAR-REGRESSION ; DIRECT-CURRENT STIMULATION ; EEG RESPONSES ; NOCICEPTIVE NEURONS ; STIMULUS SALIENCY ; FIELD POTENTIALS ; CONSCIOUS RATS ; C-FIBER
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26088
Collection中国科学院心理健康重点实验室
Corresponding AuthorL. Hu
Affiliation1.Shenzhen Univ, Coll Psychol & Sociol, Shenzhen, Peoples R China
2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
5.Peking Univ, Neurosci Res Inst, Minist Educ, Natl Hlth & Planning Commiss, Beijing, Peoples R China
6.Peking Univ, Key Lab Neurosci, Minist Educ, Natl Hlth & Planning Commiss, Beijing, Peoples R China
7.Shenzhen Univ, Sch Biomed Engn, Shenzhen, Peoples R China
8.UCL, Dept Neurosci Physiol & Pharmacol, London, England
Recommended Citation
GB/T 7714
Peng, Weiwei,Xia, Xiaolei,Yi, Ming,et al. Brain oscillations reflecting pain-related behavior in freely moving rats[J]. PAIN,2018,159(1):106-118.
APA Peng, Weiwei.,Xia, Xiaolei.,Yi, Ming.,Huang, Gan.,Zhang, Zhiguo.,...&L. Hu.(2018).Brain oscillations reflecting pain-related behavior in freely moving rats.PAIN,159(1),106-118.
MLA Peng, Weiwei,et al."Brain oscillations reflecting pain-related behavior in freely moving rats".PAIN 159.1(2018):106-118.
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