Institutional Repository of Key Laboratory of Mental Health, CAS
Aberrant Connectivity in Mild Cognitive Impairment and Alzheimer Disease Revealed by Multimodal Neuroimaging Data | |
Li, Qing1; Wu, Xia1,2; Xie, Fufang1; Chen, Kewei3,4; Yao, Li1,2; Zhang, Jiacai1; Guo, Xiaojuan1; Li, Rui5; Alzheimers Dis Neuroimaging Initi | |
第一作者 | Li, Qing |
通讯作者邮箱 | wuxia @ bnu.edu.cn |
心理所单位排序 | 4 |
摘要 | Background: Making use of multimodal data simultaneously to understand the neural mechanism of mild cognitive impairment (MCI) has been in the focus nowadays. The simultaneous use of multimodal data can take advantage of each modality which may only provide the view of one specific aspect of the brain. Objective: To this end, the present study used structural magnetic resonance imaging (sMRI), fluorodeoxyglucose positron emission tomography (FDG-PET) and florbetapir PET to reveal the integrated brain network between MCI and normal controls (NCs). Methods: In this study, 116 MCI, 116 NC and 116 Alzheimer disease (AD) subjects from the Alzheimer's Disease Neuroimaging Initiative were included for the evaluation of the brain covariance graphic model. Sparse inverse covariance estimation was utilized to get the graphic model. Results: The connections among different brain regions were quite different between NC and MCI or between MCI and AD subjects (p < 0.01). The number of connections, which were represented by the covariance among different brain regions in the graphic model, decreased from NC to MCI and then AD, especially in the temporal lobe, occipital-parietal lobe and parietal-temporal lobe. Conclusion: These findings are good evidence to reveal the difference between MCI or AD and NC, and enhance the understanding of MCI. (c) 2018 S. Karger AG, Basel |
关键词 | Alzheimer disease Brain disorders Mild cognitive impairment Multimodal imaging Sparse inverse covariance estimation |
2018 | |
语种 | 英语 |
DOI | 10.1159/000484248 |
发表期刊 | NEURODEGENERATIVE DISEASES |
ISSN | 1660-2854 |
卷号 | 18期号:1页码:5-18 |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | FUNCTIONAL CONNECTIVITY ; SPARSE REPRESENTATION ; CEREBROSPINAL-FLUID ; BIPOLAR DISORDER ; MCI PATIENTS ; MR-IMAGES ; BRAIN ; PET ; CLASSIFICATION ; SCHIZOPHRENIA |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Clinical Neurology ; Neurosciences |
WOS记录号 | WOS:000427730100002 |
Q分类 | Q2 |
资助机构 | Funds for International Cooperation and Exchanges of the National Natural Science Foundation of China(61210001) ; General Program of National Natural Science Foundation of China(61571047) ; Fundamental Research Funds for the Central Universities(2017EYT36) ; Fundamental Research Funds of the Central Universities(2017STUD34) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/26095 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Wu, Xia |
作者单位 | 1.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing 100875, Peoples R China 2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 3.Banner Alzheimers Inst, Phoenix, AZ USA 4.Banner Good Samaritan PET Ctr, Phoenix, AZ USA 5.Ctr Aging Psychol, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Qing,Wu, Xia,Xie, Fufang,et al. Aberrant Connectivity in Mild Cognitive Impairment and Alzheimer Disease Revealed by Multimodal Neuroimaging Data[J]. NEURODEGENERATIVE DISEASES,2018,18(1):5-18. |
APA | Li, Qing.,Wu, Xia.,Xie, Fufang.,Chen, Kewei.,Yao, Li.,...&Alzheimers Dis Neuroimaging Initi.(2018).Aberrant Connectivity in Mild Cognitive Impairment and Alzheimer Disease Revealed by Multimodal Neuroimaging Data.NEURODEGENERATIVE DISEASES,18(1),5-18. |
MLA | Li, Qing,et al."Aberrant Connectivity in Mild Cognitive Impairment and Alzheimer Disease Revealed by Multimodal Neuroimaging Data".NEURODEGENERATIVE DISEASES 18.1(2018):5-18. |
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