精神分裂症谱系的期待性快感缺乏与纹状体功能紊乱 | |
Alternative Title | Impairments of anticipatory pleasure and altered striatal activation in schizophrenia spectrum disorders |
李直 | |
Subtype | 博士 |
Thesis Advisor | 陈楚侨 |
2018-06 | |
Degree Grantor | 中国科学院研究生院 |
Place of Conferral | 北京 |
Degree Discipline | 认知神经科学 |
Keyword | 精神分裂症谱系 快感缺乏 纹状体 伏隔核 实时脑成像 |
Abstract |
愉快体验在时间维度上可以被划分为期待性和即时性愉快体验,二者被证实具有不同的神经机制。精神分裂症患者在期待性愉快体验上存在缺损,即期待性快感缺乏,但他们的即时性愉快体验则保存相对完好。同时,脑影像研究也发现精神分裂症患者在对正性刺激期待时的腹侧纹状体活动要显著弱于健康对照组。另外快感缺乏具有较高的遗传度,其与分裂型特质不同程度的基因关联也提示了快感缺乏与精神分裂症发病的病理生理学联系。然而,尚无研究从谱系角度切入,研究包括患者未患病一级家属与分裂型特质的期待性快感缺乏及其神经机制。而期待性愉快体验背后神经机制的遗传特性也尚待澄清。本研究分别从行为、脑影像及遗传三个层面对精神分裂症谱系的期待性快感缺乏予以探讨,力图揭示愉快体验在精神疾病病理生理学机制所扮演的角色,并设计一套针对期待性快感缺乏的非药物干预系统。 |
Other Abstract |
Pleasure experience can be parsed into anticipatory and consummatory pleasure,which are presumed to have different underlying neural mechanisms. Patients with schizophrenia have been reported to exhibit impairment in anticipatory pleasure, but largely intact consummatory pleasure. In addition, patients with schizophrenia have been shown to have dampened striatal activation when anticipating monetary incentives compared with healthy controls. There is evidence suggesting that anhedonia may also be heritable. However, few studies have examined anhedonia in others groups along the schizophrenia spectrum, such as unaffected first-degree relatives of patients with schizophrenia and individuals with schizotypal personality features. Furthermore, the heritability of striatal activation when anticipating monetary incentives has not been investigated. This study examine anhedonia in people with schizophrenia spectrum disorders from the behavioural,imaging and genetic perspectives. We also designed and tested a real-time fMRI-based neurofeedback system to improve anticipatory pleasure.d anticipatory . |
Language | 中文 |
Document Type | 学位论文 |
Identifier | http://ir.psych.ac.cn/handle/311026/26135 |
Collection | 健康与遗传心理学研究室 |
Affiliation | 中国科学院心理研究所 |
Recommended Citation GB/T 7714 | 李直. 精神分裂症谱系的期待性快感缺乏与纹状体功能紊乱[D]. 北京. 中国科学院研究生院,2018. |
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李直--博士学位论文.pdf(2031KB) | 学位论文 | 限制开放 | CC BY-NC-SA | Application Full Text |
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