Institutional Repository of Key Laboratory of Mental Health, CAS
Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder | |
Sun, Xiao1,2; Wu, Zhaomin5; Cao, Qingjiu1,2; Qian, Ying1,2; Liu, Yong3,4; Yang, Binrang5; Chang, Suhua3,6; Yang, Li1,2; Wang, Yufeng1,2 | |
通讯作者邮箱 | changsh@psych.ac.cn ; yangli_pkuimh@bjmu.edu.cn) |
心理所单位排序 | 3 |
摘要 | As a childhood-onset psychiatric disorder, attention deficit hyperactivity disorder (ADHD) is complicated by phenotypic and genetic heterogeneity. Lifelong executive function deficits in ADHD are described in many literatures and have been proposed as endophenotypes of ADHD. However, its genetic basis is still elusive. In this study, we performed a genome-wide association study of executive function, rated with Behavioral Rating Inventory of Executive Function (BRIEF), in ADHD children. We identified one significant variant (rs852004, P = 2.51e-08) for the overall score of BRIEF. The association analyses for each component of executive function found this locus was more associated with inhibit and monitor components. Further principle component analysis and confirmatory factor analysis provided an ADHD-specific executive function pattern including inhibit and monitor factors. SNP rs852004 was mainly associated with the Behavioral Regulation factor. Meanwhile, we found the significant locus was associated with ADHD symptom. The Behavioral Regulation factor mediated its effect on ADHD symptom. Functional magnetic resonance imaging (fMRI) analyses further showed evidence that this variant affected the activity of inhibition control related brain regions. It provided new insights for the genetic basis of executive function in ADHD. |
2018-05-16 | |
语种 | 英语 |
DOI | 10.1038/s41598-018-26042-y |
发表期刊 | SCIENTIFIC REPORTS |
ISSN | 2045-2322 |
卷号 | 8页码:1-9 |
期刊论文类型 | Article |
收录类别 | SCI ; SSCI |
WOS关键词 | GENOME-WIDE ASSOCIATION ; DEFICIT/HYPERACTIVITY DISORDER ; COGNITIVE DYSFUNCTION ; GENOTYPE IMPUTATION ; RESPONSE-INHIBITION ; PREFRONTAL CORTEX ; BIPOLAR DISORDER ; RATING INVENTORY ; ADHD ; METAANALYSIS |
WOS标题词 | Science & Technology |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000432270500005 |
资助机构 | National Natural Science Foundation of China(81671358 ; Major State Basic Research Development Program of China (973 Program)(2014CB846100) ; Sanming Project of Medicine in Shenzhen "The ADHD research group from Peking University Sixth hospital"(SZSM201612036) ; National Key R&D Program of China(2016YFC1306103) ; 31401139) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/26199 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Inst Mental Hlth, 51 Huayuan Bei Rd, Beijing 100191, Peoples R China 2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, 51 Huayuan Bei Rd, Beijing 100191, Peoples R China 3.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 4.Beijing Jiaotong Univ, Coll Life Sci & Bioengn, 3 Shang Yuan Cun, Beijing 100044, Peoples R China 5.Shenzhen Childrens Hosp, 7019 Yitian Rd, Shenzhen 518038, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, 19 Yuquan Rd, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Xiao,Wu, Zhaomin,Cao, Qingjiu,et al. Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder[J]. SCIENTIFIC REPORTS,2018,8:1-9. |
APA | Sun, Xiao.,Wu, Zhaomin.,Cao, Qingjiu.,Qian, Ying.,Liu, Yong.,...&Wang, Yufeng.(2018).Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder.SCIENTIFIC REPORTS,8,1-9. |
MLA | Sun, Xiao,et al."Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder".SCIENTIFIC REPORTS 8(2018):1-9. |
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