PSYCH OpenIR  > 中国科学院心理健康重点实验室
Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder
Sun, Xiao1,2; Wu, Zhaomin5; Cao, Qingjiu1,2; Qian, Ying1,2; Liu, Yong3,4; Yang, Binrang5; Chang, Suhua3,6; Yang, Li1,2; Wang, Yufeng1,2
2018-05-16
Source PublicationSCIENTIFIC REPORTS
Correspondent Emailchangsh@psych.ac.cn ; yangli_pkuimh@bjmu.edu.cn)
ISSN2045-2322
SubtypeArticle
Volume8Pages:1-9
Contribution Rank3
Abstract

As a childhood-onset psychiatric disorder, attention deficit hyperactivity disorder (ADHD) is complicated by phenotypic and genetic heterogeneity. Lifelong executive function deficits in ADHD are described in many literatures and have been proposed as endophenotypes of ADHD. However, its genetic basis is still elusive. In this study, we performed a genome-wide association study of executive function, rated with Behavioral Rating Inventory of Executive Function (BRIEF), in ADHD children. We identified one significant variant (rs852004, P = 2.51e-08) for the overall score of BRIEF. The association analyses for each component of executive function found this locus was more associated with inhibit and monitor components. Further principle component analysis and confirmatory factor analysis provided an ADHD-specific executive function pattern including inhibit and monitor factors. SNP rs852004 was mainly associated with the Behavioral Regulation factor. Meanwhile, we found the significant locus was associated with ADHD symptom. The Behavioral Regulation factor mediated its effect on ADHD symptom. Functional magnetic resonance imaging (fMRI) analyses further showed evidence that this variant affected the activity of inhibition control related brain regions. It provided new insights for the genetic basis of executive function in ADHD.

DOI10.1038/s41598-018-26042-y
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81671358 ; Major State Basic Research Development Program of China (973 Program)(2014CB846100) ; Sanming Project of Medicine in Shenzhen "The ADHD research group from Peking University Sixth hospital"(SZSM201612036) ; National Key R&D Program of China(2016YFC1306103) ; 31401139)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000432270500005
WOS HeadingsScience & Technology
WOS KeywordGENOME-WIDE ASSOCIATION ; DEFICIT/HYPERACTIVITY DISORDER ; COGNITIVE DYSFUNCTION ; GENOTYPE IMPUTATION ; RESPONSE-INHIBITION ; PREFRONTAL CORTEX ; BIPOLAR DISORDER ; RATING INVENTORY ; ADHD ; METAANALYSIS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26199
Collection中国科学院心理健康重点实验室
Affiliation1.Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Inst Mental Hlth, 51 Huayuan Bei Rd, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, 51 Huayuan Bei Rd, Beijing 100191, Peoples R China
3.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
4.Beijing Jiaotong Univ, Coll Life Sci & Bioengn, 3 Shang Yuan Cun, Beijing 100044, Peoples R China
5.Shenzhen Childrens Hosp, 7019 Yitian Rd, Shenzhen 518038, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, 19 Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Sun, Xiao,Wu, Zhaomin,Cao, Qingjiu,et al. Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder[J]. SCIENTIFIC REPORTS,2018,8:1-9.
APA Sun, Xiao.,Wu, Zhaomin.,Cao, Qingjiu.,Qian, Ying.,Liu, Yong.,...&Wang, Yufeng.(2018).Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder.SCIENTIFIC REPORTS,8,1-9.
MLA Sun, Xiao,et al."Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder".SCIENTIFIC REPORTS 8(2018):1-9.
Files in This Item:
File Name/Size DocType Version Access License
Genetic variant for (1660KB)期刊论文作者接受稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Sun, Xiao]'s Articles
[Wu, Zhaomin]'s Articles
[Cao, Qingjiu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Sun, Xiao]'s Articles
[Wu, Zhaomin]'s Articles
[Cao, Qingjiu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Sun, Xiao]'s Articles
[Wu, Zhaomin]'s Articles
[Cao, Qingjiu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorde.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.