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Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder
Sun, Xiao1,2; Wu, Zhaomin5; Cao, Qingjiu1,2; Qian, Ying1,2; Liu, Yong3,4; Yang, Binrang5; Chang, Suhua3,6; Yang, Li1,2; Wang, Yufeng1,2
2018-05-16
发表期刊SCIENTIFIC REPORTS
通讯作者邮箱changsh@psych.ac.cn ; yangli_pkuimh@bjmu.edu.cn)
ISSN2045-2322
文章类型Article
卷号8页码:1-9
产权排序3
摘要

As a childhood-onset psychiatric disorder, attention deficit hyperactivity disorder (ADHD) is complicated by phenotypic and genetic heterogeneity. Lifelong executive function deficits in ADHD are described in many literatures and have been proposed as endophenotypes of ADHD. However, its genetic basis is still elusive. In this study, we performed a genome-wide association study of executive function, rated with Behavioral Rating Inventory of Executive Function (BRIEF), in ADHD children. We identified one significant variant (rs852004, P = 2.51e-08) for the overall score of BRIEF. The association analyses for each component of executive function found this locus was more associated with inhibit and monitor components. Further principle component analysis and confirmatory factor analysis provided an ADHD-specific executive function pattern including inhibit and monitor factors. SNP rs852004 was mainly associated with the Behavioral Regulation factor. Meanwhile, we found the significant locus was associated with ADHD symptom. The Behavioral Regulation factor mediated its effect on ADHD symptom. Functional magnetic resonance imaging (fMRI) analyses further showed evidence that this variant affected the activity of inhibition control related brain regions. It provided new insights for the genetic basis of executive function in ADHD.

DOI10.1038/s41598-018-26042-y
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(81671358 ; Major State Basic Research Development Program of China (973 Program)(2014CB846100) ; Sanming Project of Medicine in Shenzhen "The ADHD research group from Peking University Sixth hospital"(SZSM201612036) ; National Key R&D Program of China(2016YFC1306103) ; 31401139)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000432270500005
WOS标题词Science & Technology
关键词[WOS]GENOME-WIDE ASSOCIATION ; DEFICIT/HYPERACTIVITY DISORDER ; COGNITIVE DYSFUNCTION ; GENOTYPE IMPUTATION ; RESPONSE-INHIBITION ; PREFRONTAL CORTEX ; BIPOLAR DISORDER ; RATING INVENTORY ; ADHD ; METAANALYSIS
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26199
专题中国科学院心理健康重点实验室
作者单位1.Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, Inst Mental Hlth, 51 Huayuan Bei Rd, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, 51 Huayuan Bei Rd, Beijing 100191, Peoples R China
3.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
4.Beijing Jiaotong Univ, Coll Life Sci & Bioengn, 3 Shang Yuan Cun, Beijing 100044, Peoples R China
5.Shenzhen Childrens Hosp, 7019 Yitian Rd, Shenzhen 518038, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, 19 Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Sun, Xiao,Wu, Zhaomin,Cao, Qingjiu,et al. Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder[J]. SCIENTIFIC REPORTS,2018,8:1-9.
APA Sun, Xiao.,Wu, Zhaomin.,Cao, Qingjiu.,Qian, Ying.,Liu, Yong.,...&Wang, Yufeng.(2018).Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder.SCIENTIFIC REPORTS,8,1-9.
MLA Sun, Xiao,et al."Genetic variant for behavioral regulation factor of executive function and its possible brain mechanism in attention deficit hyperactivity disorder".SCIENTIFIC REPORTS 8(2018):1-9.
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