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A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese
Zhang, Kunlin1,2,3; Wang, Li1,2,3; Cao, Chengqi1,2,4; Li, Gen1,2,3; Fang, Ruojiao1,2,3; Liu, Ping5; Luo, Shu5; Zhang, Xiangyang1,2,3; Liberzon, Israel6,7,8; Li Wang
2018-04-30
发表期刊FRONTIERS IN PSYCHIATRY
通讯作者邮箱wangli1@psych.ac.cn
ISSN1664-0640
文章类型Article
卷号9页码:1-9
产权排序1
摘要

Objective: Post-traumatic stress disorder (PTSD) is a trauma-and stress-related psychiatric syndrome that occurs after exposure to extraordinary stressors. The neurotransmitter dopamine (DA) plays important roles in neurobiological processes like reward and stress, and a link between PTSD and the dopaminergic system has been reported. Thus, the investigation of an association between PTSD and gene-gene interaction (epistasis) within dopaminergic genes could uncover the genetic basis of dopamine-related PTSD symptomatology and contribute to precision medicine.

关键词post-traumatic stress disorder (PTSD) dopaminergic genes DRD2/ANNK1-COMT interaction modulate functional variants
DOI10.3389/fpsyt.2018.00170
收录类别SCI ; SSCI
语种英语
项目资助者External Cooperation Program of Chinese Academy of Sciences(153111KYSB20160036) ; National Natural Science Foundation of China(31471004 ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education(16JJD190006) ; 31470070 ; 31271099)
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000431132500001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]HUMAN GENETIC-VARIATION ; EARTHQUAKE SURVIVORS ; COMPLEX TRAITS ; RECEPTOR GENE ; DOPAMINE ; PTSD ; ASSOCIATION ; POLYMORPHISMS ; SYMPTOMS ; DEPRESSION
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26200
专题中国科学院心理健康重点实验室
通讯作者Li Wang
作者单位1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Lab Traumat Stress Studies, Beijing, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Ctr Genet & BioMed Informat Res, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China
5.Peoples Hosp Deyang, Deyang, Peoples R China
6.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
7.VA Ann Arbor Healthcare Syst, Mental Hlth Serv, Ann Arbor, MI USA
8.Univ Michigan, Dept Psychol, Ann Arbor, MI USA
推荐引用方式
GB/T 7714
Zhang, Kunlin,Wang, Li,Cao, Chengqi,et al. A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese[J]. FRONTIERS IN PSYCHIATRY,2018,9:1-9.
APA Zhang, Kunlin.,Wang, Li.,Cao, Chengqi.,Li, Gen.,Fang, Ruojiao.,...&Li Wang.(2018).A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese.FRONTIERS IN PSYCHIATRY,9,1-9.
MLA Zhang, Kunlin,et al."A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese".FRONTIERS IN PSYCHIATRY 9(2018):1-9.
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