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A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese
Zhang, Kunlin1,2,3; Wang, Li1,2,3; Cao, Chengqi1,2,4; Li, Gen1,2,3; Fang, Ruojiao1,2,3; Liu, Ping5; Luo, Shu5; Zhang, Xiangyang1,2,3; Liberzon, Israel6,7,8; Li Wang
2018-04-30
Source PublicationFRONTIERS IN PSYCHIATRY
Correspondent Emailwangli1@psych.ac.cn
ISSN1664-0640
SubtypeArticle
Volume9Pages:1-9
Contribution Rank1
Abstract

Objective: Post-traumatic stress disorder (PTSD) is a trauma-and stress-related psychiatric syndrome that occurs after exposure to extraordinary stressors. The neurotransmitter dopamine (DA) plays important roles in neurobiological processes like reward and stress, and a link between PTSD and the dopaminergic system has been reported. Thus, the investigation of an association between PTSD and gene-gene interaction (epistasis) within dopaminergic genes could uncover the genetic basis of dopamine-related PTSD symptomatology and contribute to precision medicine.

Keywordpost-traumatic stress disorder (PTSD) dopaminergic genes DRD2/ANNK1-COMT interaction modulate functional variants
DOI10.3389/fpsyt.2018.00170
Indexed BySCI ; SSCI
Language英语
Funding OrganizationExternal Cooperation Program of Chinese Academy of Sciences(153111KYSB20160036) ; National Natural Science Foundation of China(31471004 ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education(16JJD190006) ; 31470070 ; 31271099)
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000431132500001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordHUMAN GENETIC-VARIATION ; EARTHQUAKE SURVIVORS ; COMPLEX TRAITS ; RECEPTOR GENE ; DOPAMINE ; PTSD ; ASSOCIATION ; POLYMORPHISMS ; SYMPTOMS ; DEPRESSION
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26200
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi Wang
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Lab Traumat Stress Studies, Beijing, Peoples R China
2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Ctr Genet & BioMed Informat Res, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen, Peoples R China
5.Peoples Hosp Deyang, Deyang, Peoples R China
6.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
7.VA Ann Arbor Healthcare Syst, Mental Hlth Serv, Ann Arbor, MI USA
8.Univ Michigan, Dept Psychol, Ann Arbor, MI USA
Recommended Citation
GB/T 7714
Zhang, Kunlin,Wang, Li,Cao, Chengqi,et al. A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese[J]. FRONTIERS IN PSYCHIATRY,2018,9:1-9.
APA Zhang, Kunlin.,Wang, Li.,Cao, Chengqi.,Li, Gen.,Fang, Ruojiao.,...&Li Wang.(2018).A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese.FRONTIERS IN PSYCHIATRY,9,1-9.
MLA Zhang, Kunlin,et al."A DRD2/ANNK1-COMT Interaction, Consisting of Functional Variants, Confers Risk of Post-traumatic Stress Disorder in Traumatized Chinese".FRONTIERS IN PSYCHIATRY 9(2018):1-9.
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