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Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress
Wang, Qiong1,2,3; Shao, Feng4; Wang, Weiwen1,2,3
第一作者Qiong Wang
2018
发表期刊NEURAL PLASTICITY
通讯作者邮箱feng shao; shaof@pku.edu.cn ; weiwen wang; wangww@psych.ac.cn
ISSN2090-5904
文章类型Article
页码1-12
摘要

Cognitive dysfunctions are highly comorbid with depression. Impairments of cognitive flexibility, which are modulated by the monoaminergic system of the prefrontal cortex (PFC), are increasingly recognized as an important component of the pathophysiology and treatment of depression. However, the downstream molecular mechanisms remain unclear. Using a classical model of depression, this study investigated the effects of social defeat stress on emotional behaviors, on cognitive flexibility in the attentional set-shifting task (AST), and on the expression of extracellular signal-regulated kinase 1 and 2 (ERK1 and ERK2) and their downstream signaling molecules cAMP-response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in two subregions of the PFC, the medial prefrontal cortex (mPFC), and the orbitofrontal cortex (OFC). The results showed that stress induced emotional and cognitive alterations associated with depression, including a decreased sucrose intake ratio and impaired reversal learning and set-shifting performance in the AST. Additionally, rats in the stress group showed a significant decrease only in ERK2 signaling in the mPFC, while more extensive decreases in both ERK1 signaling and ERK2 signaling were observed in the OFC. Along with the decreased ERK signaling, compared to controls, stressed rats showed downregulation of CREB phosphorylation and BDNF expression in both the OFC and the mPFC. Further analysis showed that behavioral changes were differentially correlated with several molecules in subregions of the PFC. These results suggested that social defeat stress was an effective animal model to induce both emotional and cognitive symptoms of depression and that the dysfunction of ERK signaling activities in the PFC might be a potential underlying biological mechanism.

DOI10.1155/2018/9870985
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81471122 ; Chinese Academy of Sciences(KJZDEW-L04) ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Starting Foundation for Youth Teachers from Zhengzhou University(32210394) ; 31470988)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000430694700001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]Neurotrophic Factor Expression ; Element-binding Protein ; Long-term-memory ; Prefrontal Cortex ; Monoaminergic Modulation ; Orbitofrontal Cortex ; Synaptic Plasticity ; Depression ; Brain ; Creb
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26206
专题中国科学院心理健康重点实验室
作者单位1.CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Zhengzhou Univ, Sch Educ, Zhengzhou, Henan, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China
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Wang, Qiong,Shao, Feng,Wang, Weiwen. Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress[J]. NEURAL PLASTICITY,2018:1-12.
APA Wang, Qiong,Shao, Feng,&Wang, Weiwen.(2018).Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress.NEURAL PLASTICITY,1-12.
MLA Wang, Qiong,et al."Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress".NEURAL PLASTICITY (2018):1-12.
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