PSYCH OpenIR  > 中国科学院心理健康重点实验室
Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress
Wang, Qiong1,2,3; Shao, Feng4; Wang, Weiwen1,2,3
First AuthorQiong Wang
Correspondent Emailfeng shao; ; weiwen wang;

Cognitive dysfunctions are highly comorbid with depression. Impairments of cognitive flexibility, which are modulated by the monoaminergic system of the prefrontal cortex (PFC), are increasingly recognized as an important component of the pathophysiology and treatment of depression. However, the downstream molecular mechanisms remain unclear. Using a classical model of depression, this study investigated the effects of social defeat stress on emotional behaviors, on cognitive flexibility in the attentional set-shifting task (AST), and on the expression of extracellular signal-regulated kinase 1 and 2 (ERK1 and ERK2) and their downstream signaling molecules cAMP-response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in two subregions of the PFC, the medial prefrontal cortex (mPFC), and the orbitofrontal cortex (OFC). The results showed that stress induced emotional and cognitive alterations associated with depression, including a decreased sucrose intake ratio and impaired reversal learning and set-shifting performance in the AST. Additionally, rats in the stress group showed a significant decrease only in ERK2 signaling in the mPFC, while more extensive decreases in both ERK1 signaling and ERK2 signaling were observed in the OFC. Along with the decreased ERK signaling, compared to controls, stressed rats showed downregulation of CREB phosphorylation and BDNF expression in both the OFC and the mPFC. Further analysis showed that behavioral changes were differentially correlated with several molecules in subregions of the PFC. These results suggested that social defeat stress was an effective animal model to induce both emotional and cognitive symptoms of depression and that the dysfunction of ERK signaling activities in the PFC might be a potential underlying biological mechanism.

Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(81471122 ; Chinese Academy of Sciences(KJZDEW-L04) ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Starting Foundation for Youth Teachers from Zhengzhou University(32210394) ; 31470988)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000430694700001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordNeurotrophic Factor Expression ; Element-binding Protein ; Long-term-memory ; Prefrontal Cortex ; Monoaminergic Modulation ; Orbitofrontal Cortex ; Synaptic Plasticity ; Depression ; Brain ; Creb
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Zhengzhou Univ, Sch Educ, Zhengzhou, Henan, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Qiong,Shao, Feng,Wang, Weiwen. Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress[J]. NEURAL PLASTICITY,2018:1-12.
APA Wang, Qiong,Shao, Feng,&Wang, Weiwen.(2018).Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress.NEURAL PLASTICITY,1-12.
MLA Wang, Qiong,et al."Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the PFC in Rats after Social Defeat Stress".NEURAL PLASTICITY (2018):1-12.
Files in This Item:
File Name/Size DocType Version Access License
Region-Dependent Alt(1977KB)期刊论文作者接受稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Qiong]'s Articles
[Shao, Feng]'s Articles
[Wang, Weiwen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Qiong]'s Articles
[Shao, Feng]'s Articles
[Wang, Weiwen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Qiong]'s Articles
[Shao, Feng]'s Articles
[Wang, Weiwen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.