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Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents
Jin, Q. Q.1,2; Wu, G. Q.1,2; Peng, W. W.3; Xia, X. L.1,2; Hu, L.1,2; Iannetti, G. D.4,5
2018-06-13
发表期刊JOURNAL OF NEUROSCIENCE
ISSN0270-6474
卷号38期号:24页码:5538-5550
摘要

There is now compelling evidence that selective stimulation of A delta nociceptors eliciting first pain evokes robust responses in the primary somatosensory cortex (S1). In contrast, whether the C-fiber nociceptive input eliciting second pain has an organized projection to S1 remains an open question. Here, we recorded the electrocortical responses elicited by nociceptive-specific laser stimulation of the four limbs in 202 humans (both males and females, using EEG) and 12 freely moving rats (all males, using ECoG). Topographical analysis and source modeling revealed in both species, a clear gross somatotopy of the unmyelinated C-fiber input within the S1 contralateral to the stimulated side. In the human EEG, S1 activity could be isolated as an early-latency negative deflection (C-N1 wave peaking at 710-730 ms) after hand stimulation, but not after foot stimulation because of the spatiotemporal overlap with the subsequent large-amplitude supramodal vertex waves (C-N2/P2). In contrast, because of the across-species difference in the representation of the body surface within S1, S1 activity could be isolated in rat ECoG as a C-N1 after both forepaw and hindpaw stimulation. Finally, we observed a functional dissociation between the generators of the somatosensory-specific lateralized waves (C-N1) and those of the supramodal vertex waves (C-N2/P2), indicating that C-fiber unmyelinated input is processed in functionally distinct somatosensory and multimodal cortical areas. These findings demonstrated that C-fiber input conveys information about the spatial location of noxious stimulation across the body surface, a prerequisite for deploying an appropriate defensive motor repertoire.

关键词c Fibers Electrocorticography (Ecog) Electroencephalography (Eeg) Multispecies Investigations Pain Primary Somatosensory Cortex (S1)
DOI10.1523/JNEUROSCI.3654-17.2018
语种英语
项目资助者National Natural Science Foundation of China ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Wellcome Trust ; European Research Council ; Paris Institute for Advanced Studies
资助项目National Natural Science Foundation of China[31471082] ; National Natural Science Foundation of China[31671141] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13506] ; Wellcome Trust ; European Research Council ; Paris Institute for Advanced Studies
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000435413600008
出版者SOC NEUROSCIENCE
关键词[WOS]Evoked Cerebral Potentials ; A-delta-fiber ; Nociceptive Stimuli ; Brain Potentials ; Eeg Responses ; C-fiber ; Co2-laser Stimulation ; Laser Stimuli ; Perception ; Skin
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26293
专题中国科学院心理健康重点实验室
通讯作者Hu, L.
作者单位1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Shenzhen Univ, Brain Funct & Psychol Sci Res Ctr, Shenzhen 518060, Peoples R China
4.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
5.Ist Italiano Tecnol, I-16163 Genoa, Italy
推荐引用方式
GB/T 7714
Jin, Q. Q.,Wu, G. Q.,Peng, W. W.,et al. Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents[J]. JOURNAL OF NEUROSCIENCE,2018,38(24):5538-5550.
APA Jin, Q. Q.,Wu, G. Q.,Peng, W. W.,Xia, X. L.,Hu, L.,&Iannetti, G. D..(2018).Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents.JOURNAL OF NEUROSCIENCE,38(24),5538-5550.
MLA Jin, Q. Q.,et al."Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents".JOURNAL OF NEUROSCIENCE 38.24(2018):5538-5550.
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