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Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents
Jin, Q. Q.1,2; Wu, G. Q.1,2; Peng, W. W.3; Xia, X. L.1,2; Hu, L.1,2; Iannetti, G. D.4,5
2018-06-13
Source PublicationJOURNAL OF NEUROSCIENCE
ISSN0270-6474
Volume38Issue:24Pages:5538-5550
Abstract

There is now compelling evidence that selective stimulation of A delta nociceptors eliciting first pain evokes robust responses in the primary somatosensory cortex (S1). In contrast, whether the C-fiber nociceptive input eliciting second pain has an organized projection to S1 remains an open question. Here, we recorded the electrocortical responses elicited by nociceptive-specific laser stimulation of the four limbs in 202 humans (both males and females, using EEG) and 12 freely moving rats (all males, using ECoG). Topographical analysis and source modeling revealed in both species, a clear gross somatotopy of the unmyelinated C-fiber input within the S1 contralateral to the stimulated side. In the human EEG, S1 activity could be isolated as an early-latency negative deflection (C-N1 wave peaking at 710-730 ms) after hand stimulation, but not after foot stimulation because of the spatiotemporal overlap with the subsequent large-amplitude supramodal vertex waves (C-N2/P2). In contrast, because of the across-species difference in the representation of the body surface within S1, S1 activity could be isolated in rat ECoG as a C-N1 after both forepaw and hindpaw stimulation. Finally, we observed a functional dissociation between the generators of the somatosensory-specific lateralized waves (C-N1) and those of the supramodal vertex waves (C-N2/P2), indicating that C-fiber unmyelinated input is processed in functionally distinct somatosensory and multimodal cortical areas. These findings demonstrated that C-fiber input conveys information about the spatial location of noxious stimulation across the body surface, a prerequisite for deploying an appropriate defensive motor repertoire.

Keywordc Fibers Electrocorticography (Ecog) Electroencephalography (Eeg) Multispecies Investigations Pain Primary Somatosensory Cortex (S1)
DOI10.1523/JNEUROSCI.3654-17.2018
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Wellcome Trust ; European Research Council ; Paris Institute for Advanced Studies
Funding ProjectNational Natural Science Foundation of China[31471082] ; National Natural Science Foundation of China[31671141] ; Scientific Foundation project of Institute of Psychology, Chinese Academy of Sciences[Y6CX021008] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13506] ; Wellcome Trust ; European Research Council ; Paris Institute for Advanced Studies
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000435413600008
PublisherSOC NEUROSCIENCE
WOS KeywordEvoked Cerebral Potentials ; A-delta-fiber ; Nociceptive Stimuli ; Brain Potentials ; Eeg Responses ; C-fiber ; Co2-laser Stimulation ; Laser Stimuli ; Perception ; Skin
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26293
Collection中国科学院心理健康重点实验室
Corresponding AuthorHu, L.
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Shenzhen Univ, Brain Funct & Psychol Sci Res Ctr, Shenzhen 518060, Peoples R China
4.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
5.Ist Italiano Tecnol, I-16163 Genoa, Italy
Recommended Citation
GB/T 7714
Jin, Q. Q.,Wu, G. Q.,Peng, W. W.,et al. Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents[J]. JOURNAL OF NEUROSCIENCE,2018,38(24):5538-5550.
APA Jin, Q. Q.,Wu, G. Q.,Peng, W. W.,Xia, X. L.,Hu, L.,&Iannetti, G. D..(2018).Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents.JOURNAL OF NEUROSCIENCE,38(24),5538-5550.
MLA Jin, Q. Q.,et al."Somatotopic Representation of Second Pain in the Primary Somatosensory Cortex of Humans and Rodents".JOURNAL OF NEUROSCIENCE 38.24(2018):5538-5550.
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