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From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression
Stapelberg, N. J. C.1,2; Pratt, R.3; Neumann, D. L.4; Shum, D. H. K.4,5; Brandis, S.6; Muthukkumarasamy, V.7; Stantic, B.7; Blumenstein, M.8; Headrick, J. P.9
2018-07-01
发表期刊NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN0149-7634
卷号90页码:1-15
摘要Background: Biological pathways underlying major depressive disorder (MDD) can be viewed as systems biology networks. The psycho-immune-neuroendocrine (PINE) network comprises central nervous, immune, endocrine and autonomic systems, integrating biological mechanisms of MDD. Such networks exhibit recurrent motifs with specific functions, including positive and negative feedback loops, and are subject to critical transitions, influenced by feedback loop transitions (FLTs). Aims: We aim to identify critical feedback loops and their FLTs, as well sentinel network nodes (SNNs), key network nodes that drive FLTs, within the PINE network. Examples of biomarkers are provided which may reflect early warning signs of impending critical transition to MDD. Results: Disruption of homeostatic feedback loops reflects the physiological transition to MDD. Putative FLTs are identified within hypothalamic-pituitary-adrenal (HPA) and sympathetic-parasympathetic axes, the kynurenine pathway, gut function and dysbiosis. Conclusions: Progression from health to disease is driven by FLTs in the PINE network, which is likely to undergo changes characteristic of system instability. Biomarkers of system instability may effectively predict the critical transition to MDD.
关键词Major depressive disorder Critical transition Feedback loop transition biomarker Psycho-immune-neuroendocrine network Feedback loop Network motif
DOI10.1016/j.neubiorev.2018.03.005
语种英语
项目资助者Gold Coast Hospital and Health Service Private Practice Trust Fund Grant
资助项目Gold Coast Hospital and Health Service Private Practice Trust Fund Grant[PPTF-132-17.12.15]
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000436350200001
出版者PERGAMON-ELSEVIER SCIENCE LTD
关键词[WOS]GLUCOCORTICOID-RECEPTOR PHOSPHORYLATION ; NF-KAPPA-B ; GRAM-NEGATIVE ENTEROBACTERIA ; PITUITARY-ADRENAL AXIS ; CORONARY-HEART-DISEASE ; EARLY WARNING SIGNAL ; SEX-DIFFERENCES ; HIPPOCAMPAL NEUROGENESIS ; ANTIDEPRESSANT RESPONSE ; PROTEIN PHOSPHATASE
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26384
专题中国科学院心理健康重点实验室
通讯作者Stapelberg, N. J. C.
作者单位1.Bond Univ, Fac Hlth Sci & Med, 14 Univ Dr, Robina, Qld 4226, Australia
2.Gold Coast Hosp & Hlth Serv, 14 Univ Dr, Robina, Qld 4226, Australia
3.Gold Coast Univ Hosp, Gold Coast, Qld, Australia
4.Griffith Univ, Sch Appl Psychol, Gold Coast, Qld, Australia
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
6.Bond Univ, Fac Hlth Sci & Med, Southport, Qld 4229, Australia
7.Griffith Univ, Sch Informat & Commun Technol, Gold Coast, Qld 4222, Australia
8.Univ Technol Sydney, Fac Engn & Informat Technol, Sydney, NSW, Australia
9.Griffith Univ, Sch Med Sci, Gold Coast, Qld 4222, Australia
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GB/T 7714
Stapelberg, N. J. C.,Pratt, R.,Neumann, D. L.,et al. From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,2018,90:1-15.
APA Stapelberg, N. J. C..,Pratt, R..,Neumann, D. L..,Shum, D. H. K..,Brandis, S..,...&Headrick, J. P..(2018).From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression.NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS,90,1-15.
MLA Stapelberg, N. J. C.,et al."From feedback loop transitions to biomarkers in the psycho-immune-neuroendocrine network: Detecting the critical transition from health to major depression".NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 90(2018):1-15.
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