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Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals | |
Xie, Dong-jie1,2; Lui, Simon S. Y.1,3; Geng, Fu-lei1,4,5; Yang, Zhuo-ya1,2; Zou, Ying-min1,2; Li, Ying1,2,6; Yeung, Hera K. H.3; Cheung, Eric F. C.3; Heerey, Erin A.7; Chan, Raymond C. K.1,2 | |
第一作者 | Dong-jie Xie |
通讯作者邮箱 | rckchan@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Background. The neuropsychological origins of negative syndrome of schizophrenia remain elusive. Evidence from behavioural studies, which utilised emotion-inducing pictures to elicit motivated behaviour generally reported that that schizophrenia patients experienced similar affective experience as healthy individuals but failed to translate emotional salience to motivated behaviour, a phenomenon called emotion-behaviour decoupling. However, a few studies have examined emotion-behaviour decoupling in non-psychotic high-risk populations, who are relatively unaffected by medication effects. Methods. In this study, we examined the nature and extent of emotion-behaviour decoupling in in three independent samples (65 schizophrenia patients v. 63 controls; 40 unaffected relatives v. 45 controls; and 32 individuals with social anhedonia v. 32 controls). We administered an experimental task to examine their affective experience and its coupling with behaviour, using emotion-inducing slides, and allowed participants to alter stimulus exposure using button-pressing to seek pleasure or avoid aversion. Results. Schizophrenia patients reported similar affective experiences as their controls, while their unaffected relatives and individuals with high levels of social anhedonia exhibited attenuated affective experiences, in particular in the arousal aspect. Compared with their respective control groups, all of the three groups showed emotion-behaviour decoupling. Conclusions. Our findings support that both genetically and behaviourally high-risk groups exhibit emotion-behaviour decoupling. The familial association apparently supports its role as a putative trait marker for schizophrenia. |
关键词 | Anhedonia Avolition Emotion-behaviour Decoupling Schizophrenia Schizotypy Unaffected Relatives |
2018-07-01 | |
语种 | 英语 |
DOI | 10.1017/S0033291717002926 |
发表期刊 | PSYCHOLOGICAL MEDICINE |
ISSN | 0033-2917 |
卷号 | 48期号:9页码:1474-1483 |
资助项目 | National Science Fund China[81571317] ; National Basic Research Programme of China (Precision psychiatry Programme)[2016YFC0906402] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] |
出版者 | CAMBRIDGE UNIV PRESS |
WOS关键词 | Negative Symptoms ; Social Anhedonia ; Spectrum Disorders ; Decision-making ; Clinical-trials ; Pleasure ; Reward ; Scale ; Schizotaxia ; Validation |
WOS研究方向 | Psychology ; Psychiatry |
WOS类目 | Psychology, Clinical ; Psychiatry ; Psychology |
WOS记录号 | WOS:000435649900009 |
资助机构 | National Science Fund China ; National Basic Research Programme of China (Precision psychiatry Programme) ; Beijing Training Project for the Leading Talents in Science and Technology ; Beijing Municipal Science & Technology Commission Grant |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/26392 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Castle Peak Hosp, Hong Kong, Hong Kong Speci, Peoples R China 4.South China Normal Univ, Sch Psychol, Guangzhou, Guangdong, Peoples R China 5.South China Normal Univ, Ctr Studies Psychol Applicat, Guangzhou, Guangdong, Peoples R China 6.Haidian Dist Mental Hlth Prevent Treatment Hosp, Beijing, Peoples R China 7.Western Univ, Dept Psychol, London, ON, Canada |
第一作者单位 | 认知与发展心理学研究室 |
通讯作者单位 | 认知与发展心理学研究室 |
推荐引用方式 GB/T 7714 | Xie, Dong-jie,Lui, Simon S. Y.,Geng, Fu-lei,et al. Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals[J]. PSYCHOLOGICAL MEDICINE,2018,48(9):1474-1483. |
APA | Xie, Dong-jie.,Lui, Simon S. Y..,Geng, Fu-lei.,Yang, Zhuo-ya.,Zou, Ying-min.,...&Chan, Raymond C. K..(2018).Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals.PSYCHOLOGICAL MEDICINE,48(9),1474-1483. |
MLA | Xie, Dong-jie,et al."Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals".PSYCHOLOGICAL MEDICINE 48.9(2018):1474-1483. |
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