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Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals
Xie, Dong-jie1,2; Lui, Simon S. Y.1,3; Geng, Fu-lei1,4,5; Yang, Zhuo-ya1,2; Zou, Ying-min1,2; Li, Ying1,2,6; Yeung, Hera K. H.3; Cheung, Eric F. C.3; Heerey, Erin A.7; Chan, Raymond C. K.1,2
2018-07-01
发表期刊PSYCHOLOGICAL MEDICINE
ISSN0033-2917
卷号48期号:9页码:1474-1483
摘要Background. The neuropsychological origins of negative syndrome of schizophrenia remain elusive. Evidence from behavioural studies, which utilised emotion-inducing pictures to elicit motivated behaviour generally reported that that schizophrenia patients experienced similar affective experience as healthy individuals but failed to translate emotional salience to motivated behaviour, a phenomenon called emotion-behaviour decoupling. However, a few studies have examined emotion-behaviour decoupling in non-psychotic high-risk populations, who are relatively unaffected by medication effects. Methods. In this study, we examined the nature and extent of emotion-behaviour decoupling in in three independent samples (65 schizophrenia patients v. 63 controls; 40 unaffected relatives v. 45 controls; and 32 individuals with social anhedonia v. 32 controls). We administered an experimental task to examine their affective experience and its coupling with behaviour, using emotion-inducing slides, and allowed participants to alter stimulus exposure using button-pressing to seek pleasure or avoid aversion. Results. Schizophrenia patients reported similar affective experiences as their controls, while their unaffected relatives and individuals with high levels of social anhedonia exhibited attenuated affective experiences, in particular in the arousal aspect. Compared with their respective control groups, all of the three groups showed emotion-behaviour decoupling. Conclusions. Our findings support that both genetically and behaviourally high-risk groups exhibit emotion-behaviour decoupling. The familial association apparently supports its role as a putative trait marker for schizophrenia.
关键词Anhedonia avolition emotion-behaviour decoupling schizophrenia schizotypy unaffected relatives
DOI10.1017/S0033291717002926
语种英语
项目资助者National Science Fund China ; National Basic Research Programme of China (Precision psychiatry Programme) ; Beijing Training Project for the Leading Talents in Science and Technology ; Beijing Municipal Science & Technology Commission Grant
资助项目National Science Fund China[81571317] ; National Basic Research Programme of China (Precision psychiatry Programme)[2016YFC0906402] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138]
WOS研究方向Psychology ; Psychiatry
WOS类目Psychology, Clinical ; Psychiatry ; Psychology
WOS记录号WOS:000435649900009
出版者CAMBRIDGE UNIV PRESS
关键词[WOS]NEGATIVE SYMPTOMS ; SOCIAL ANHEDONIA ; SPECTRUM DISORDERS ; DECISION-MAKING ; CLINICAL-TRIALS ; PLEASURE ; REWARD ; SCALE ; SCHIZOTAXIA ; VALIDATION
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26392
专题中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Castle Peak Hosp, Hong Kong, Hong Kong Speci, Peoples R China
4.South China Normal Univ, Sch Psychol, Guangzhou, Guangdong, Peoples R China
5.South China Normal Univ, Ctr Studies Psychol Applicat, Guangzhou, Guangdong, Peoples R China
6.Haidian Dist Mental Hlth Prevent Treatment Hosp, Beijing, Peoples R China
7.Western Univ, Dept Psychol, London, ON, Canada
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GB/T 7714
Xie, Dong-jie,Lui, Simon S. Y.,Geng, Fu-lei,et al. Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals[J]. PSYCHOLOGICAL MEDICINE,2018,48(9):1474-1483.
APA Xie, Dong-jie.,Lui, Simon S. Y..,Geng, Fu-lei.,Yang, Zhuo-ya.,Zou, Ying-min.,...&Chan, Raymond C. K..(2018).Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals.PSYCHOLOGICAL MEDICINE,48(9),1474-1483.
MLA Xie, Dong-jie,et al."Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals".PSYCHOLOGICAL MEDICINE 48.9(2018):1474-1483.
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