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Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals
Xie, Dong-jie1,2; Lui, Simon S. Y.1,3; Geng, Fu-lei1,4,5; Yang, Zhuo-ya1,2; Zou, Ying-min1,2; Li, Ying1,2,6; Yeung, Hera K. H.3; Cheung, Eric F. C.3; Heerey, Erin A.7; Chan, Raymond C. K.1,2
First AuthorDong-jie Xie
2018-07-01
Source PublicationPSYCHOLOGICAL MEDICINE
Correspondent Emailrckchan@psych.ac.cn
ISSN0033-2917
Volume48Issue:9Pages:1474-1483
Contribution Rank1
Abstract

Background. The neuropsychological origins of negative syndrome of schizophrenia remain elusive. Evidence from behavioural studies, which utilised emotion-inducing pictures to elicit motivated behaviour generally reported that that schizophrenia patients experienced similar affective experience as healthy individuals but failed to translate emotional salience to motivated behaviour, a phenomenon called emotion-behaviour decoupling. However, a few studies have examined emotion-behaviour decoupling in non-psychotic high-risk populations, who are relatively unaffected by medication effects. Methods. In this study, we examined the nature and extent of emotion-behaviour decoupling in in three independent samples (65 schizophrenia patients v. 63 controls; 40 unaffected relatives v. 45 controls; and 32 individuals with social anhedonia v. 32 controls). We administered an experimental task to examine their affective experience and its coupling with behaviour, using emotion-inducing slides, and allowed participants to alter stimulus exposure using button-pressing to seek pleasure or avoid aversion. Results. Schizophrenia patients reported similar affective experiences as their controls, while their unaffected relatives and individuals with high levels of social anhedonia exhibited attenuated affective experiences, in particular in the arousal aspect. Compared with their respective control groups, all of the three groups showed emotion-behaviour decoupling. Conclusions. Our findings support that both genetically and behaviourally high-risk groups exhibit emotion-behaviour decoupling. The familial association apparently supports its role as a putative trait marker for schizophrenia.

KeywordAnhedonia Avolition Emotion-behaviour Decoupling Schizophrenia Schizotypy Unaffected Relatives
DOI10.1017/S0033291717002926
Language英语
Funding OrganizationNational Science Fund China ; National Basic Research Programme of China (Precision psychiatry Programme) ; Beijing Training Project for the Leading Talents in Science and Technology ; Beijing Municipal Science & Technology Commission Grant
Funding ProjectNational Science Fund China[81571317] ; National Basic Research Programme of China (Precision psychiatry Programme)[2016YFC0906402] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138]
WOS Research AreaPsychology ; Psychiatry
WOS SubjectPsychology, Clinical ; Psychiatry ; Psychology
WOS IDWOS:000435649900009
PublisherCAMBRIDGE UNIV PRESS
WOS KeywordNegative Symptoms ; Social Anhedonia ; Spectrum Disorders ; Decision-making ; Clinical-trials ; Pleasure ; Reward ; Scale ; Schizotaxia ; Validation
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26392
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Castle Peak Hosp, Hong Kong, Hong Kong Speci, Peoples R China
4.South China Normal Univ, Sch Psychol, Guangzhou, Guangdong, Peoples R China
5.South China Normal Univ, Ctr Studies Psychol Applicat, Guangzhou, Guangdong, Peoples R China
6.Haidian Dist Mental Hlth Prevent Treatment Hosp, Beijing, Peoples R China
7.Western Univ, Dept Psychol, London, ON, Canada
Recommended Citation
GB/T 7714
Xie, Dong-jie,Lui, Simon S. Y.,Geng, Fu-lei,et al. Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals[J]. PSYCHOLOGICAL MEDICINE,2018,48(9):1474-1483.
APA Xie, Dong-jie.,Lui, Simon S. Y..,Geng, Fu-lei.,Yang, Zhuo-ya.,Zou, Ying-min.,...&Chan, Raymond C. K..(2018).Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals.PSYCHOLOGICAL MEDICINE,48(9),1474-1483.
MLA Xie, Dong-jie,et al."Dissociation between affective experience and motivated behaviour in schizophrenia patients and their unaffected first-degree relatives and schizotypal individuals".PSYCHOLOGICAL MEDICINE 48.9(2018):1474-1483.
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