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Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity
Wang, Yong-ming1,2,3,4; Zou, Lai-quan1,5; Xie, Wen-lan1,4; Yang, Zhuo-ya1,4; Zhu, Xiong-zhao6,7; Cheung, Eric F. C.8; Sorensen, Thomas Alrik3,9; Moller, Arne3,10,11,12; Chan, Raymond C. K.1,2,3,4
First AuthorYong-ming Wang
Correspondent (r.c.k. chan)

Recent findings suggest that schizo-obsessive comorbidity (SOC) may be a unique diagnostic entity. We examined grey matter (GM) volume and cortical thickness in 22 patients with SOC, and compared them with 21 schizophrenia (SCZ) patients, 22 obsessive-compulsive disorder (OCD) patients and 22 healthy controls (HCs). We found that patients with SOC exhibited reduced GM volume in the left thalamus, the left inferior semi-lunar lobule of the cerebellum, the bilateral medial orbitofrontal cortex (medial oFC), the medial superior frontal gyrus (medial sFG), the rectus gyrus and the anterior cingulate cortex (aCC) compared with HCs. Patients with SOC also exhibited reduced cortical thickness in the right superior temporal gyrus (sTG), the right angular gyrus, the right supplementary motor area (SMA), the right middle cingulate cortex (mCC) and the right middle occipital gyrus (mOG) compared with HCs. Together with the differences in GM volume and cortical thickness between patients with SOC and patients with only SCZ or only OCD, these findings highlight the GM changes specific to patients with SOC.

KeywordSchizo-obsessive Comorbidity Schizophrenia Obsessive-compulsive Disorder Grey Matter Volume Cortical Thickness
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; Strategic Priority Research Program (B) of the Chinese Academy of Science[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS KeywordState Functional Connectivity ; 1st-episode Schizophrenia-patients ; 1st Episode Schizophrenia ; Anterior Cingulate Cortex ; Voxel-based Morphometry ; Middle Temporal Gyrus ; Compulsive Disorder ; Neuroimaging Findings ; Parkinsons-disease ; Bipolar Disorder
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000432907500009
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100190, Peoples R China
3.Sinodanish Ctr Educ & Res, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Southern Med Univ, Sch Publ Hlth, Dept Psychol, Guangdong Prov Key Lab Trop Dis Res, Guangzhou, Guangdong, Peoples R China
6.Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha 410011, Hunan, Peoples R China
7.Cent S Univ, Med Psychol Inst, Changsha 410011, Hunan, Peoples R China
8.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
9.Aalborg Univ, Ctr Cognit Neurosci, Inst Commun & Psychol, Aalborg, Denmark
10.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark
11.Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark
12.Aarhus Univ, Ctr Functionally Integrat Neurosci, Aarhus, Denmark
Recommended Citation
GB/T 7714
Wang, Yong-ming,Zou, Lai-quan,Xie, Wen-lan,et al. Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2018,276:65-72.
APA Wang, Yong-ming.,Zou, Lai-quan.,Xie, Wen-lan.,Yang, Zhuo-ya.,Zhu, Xiong-zhao.,...&Chan, Raymond C. K..(2018).Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity.PSYCHIATRY RESEARCH-NEUROIMAGING,276,65-72.
MLA Wang, Yong-ming,et al."Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity".PSYCHIATRY RESEARCH-NEUROIMAGING 276(2018):65-72.
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