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Interaction between job stress and the BDNF Val66Met polymorphism affects depressive symptoms in Chinese healthcare workers
He, Shu-Chang1,2; Wu, Shuang1,2; Wang, Chao1,2; Du, Xiang-Dong3; Yin, Guangzhong3; Jia, Qiufang3; Zhang, Yingyang3; Wang, Li4; Soares, Jair C.5; Zhang, Xiang Yang4,5
第一作者He, Shu-Chang
2018-08-15
发表期刊JOURNAL OF AFFECTIVE DISORDERS
通讯作者邮箱shuchangh@pku.edu.cn (s.-c. he) ; xiang.y.zhang@uth.tmc.edu (x.y. zhang)
ISSN0165-0327
卷号236页码:157-163
产权排序4
摘要

Background: Chronic exposure to job-related stress can lead to depression and BDNF polymorphism may play an important role in this process. The role of the stress x BDNF Val66Met interaction in depression has been studied widely using childhood stress, but few studies have utilized chronic stress in adulthood as a moderator. This study was to examine the chronic stress x BDNF Val66Met interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet. Methods: Using a cross-sectional design, 243 doctors and nurses were recruited from a general hospital in Beijing, and were assessed for depression with Self-rating Depression Scale (SDS), and the stress using the House and Rizzo's Work Stress Scale. The BDNF Val66Met polymorphism was genotyped. Results: There was a significant positive association between job stress and depressive scores (p < 0.001). No significant main effect of the BDNF Val66Met genotype on depressive symptoms was observed (p > 0.05). A statistically significant interaction between BDNF Val66Met and job stress on depressive symptoms was found (p < 0.05); individuals with Val/Val genotype showed a higher SDS score than Met allele carriers only in the low-stress group, without significant differences in SDS score between the BDNF Val66Met subgroups in medium-or high-stress group. Limitations: Limitations include cross-sectional study design, the small sample size only in healthcare workers and only one polymorphism in BDNF gene was analyzed. Conclusions: Our results suggest a close relationship between job-related stress and depression, and the interaction of the BDNF Val66Met polymorphism and chronic stress in adulthood may impact the depressive symptoms.

DOI10.1016/j.jad.2018.04.089
语种英语
项目资助者National Natural Science Foundation of China
资助项目National Natural Science Foundation of China[81271491] ; National Natural Science Foundation of China[81571322] ; National Natural Science Foundation of China[81371477]
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Clinical Neurology ; Psychiatry
WOS记录号WOS:000433130600024
出版者ELSEVIER SCIENCE BV
关键词[WOS]Neurotrophic Factor Gene ; Major Depression ; Cognitive Impairment ; Treatment Response ; Mood Disorders ; Risk-factors ; Brain ; Childhood ; Burnout ; Model
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26499
专题健康与遗传心理学研究室
通讯作者He, Shu-Chang; Zhang, Xiang Yang
作者单位1.Peking Univ, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
2.Peking Univ, Beijing Key Lab Behav & Mental Hlth, 5 Yiheyuan Rd, Beijing 100871, Peoples R China
3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Jiangsu, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, 1941 East Rd, Houston, TX 77054 USA
推荐引用方式
GB/T 7714
He, Shu-Chang,Wu, Shuang,Wang, Chao,et al. Interaction between job stress and the BDNF Val66Met polymorphism affects depressive symptoms in Chinese healthcare workers[J]. JOURNAL OF AFFECTIVE DISORDERS,2018,236:157-163.
APA He, Shu-Chang.,Wu, Shuang.,Wang, Chao.,Du, Xiang-Dong.,Yin, Guangzhong.,...&Zhang, Xiang Yang.(2018).Interaction between job stress and the BDNF Val66Met polymorphism affects depressive symptoms in Chinese healthcare workers.JOURNAL OF AFFECTIVE DISORDERS,236,157-163.
MLA He, Shu-Chang,et al."Interaction between job stress and the BDNF Val66Met polymorphism affects depressive symptoms in Chinese healthcare workers".JOURNAL OF AFFECTIVE DISORDERS 236(2018):157-163.
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