PSYCH OpenIR  > 健康与遗传心理学研究室
Interleukin-3, symptoms and cognitive deficits in first-episode drug-naive and chronic medicated schizophrenia
Xiu, Mei-Hong1; Wang, Dong2; Chen, Song1; Du, Xiang-Dong3; Chen, Da-Chun1; Chen, Nan1; Wang, Yue-Chan1; Yin, Guangzhong3; Zhang, Yingyang3; Tan, Yun-Long1; Cho, Raymond Y.4; Soares, Jair C.4; Zhang, Xiang-Yang5
2018-05-01
发表期刊PSYCHIATRY RESEARCH
ISSN0165-1781
卷号263页码:147-153
摘要

Previous studies consistently showed that IL-3 signaling may be involved in the pathophysiology of schizophrenia. However, investigations of associations between IL-3 and the neurocognitive impairments are lacking, including the study of how this may vary with stage of illness. We recruited 45 first-episode drug-naive (FE-Sz), 35 chronic medicated schizophrenia (Ch-Sz) and 40 healthy controls (HC) and examined the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and serum IL-3. Altered serum IL-3 levels were found in both patient groups compared with HC group (both p < 0.001). There were significantly lower neurocognitive scores on the RBANS and nearly all of its five subscales, except for Visuospatial/Constructional index in both FE-Sz and Ch-Sz patients vs healthy controls. Moreover, a significant reduction in Immediate memory index (p = 0.021) and a trend-level reduction in RBANS total score (p = 0.094) in Ch-Sz than FE-Sz patients. Interestingly, there was a significant negative correlation between IL-3 and the Immediate memory index only in Ch-Sz patients (p = 0.03). Our findings showed that neurocognitive impairments present in schizophrenia emerge during the first episode with further diminished functioning with disease progression, and IL-3 may be involved in the immediate memory deficits in the chronic phase of schizophrenia.

关键词Schizophrenia Interleukin-3 Neurocognitive Function Cytokines Immune System
DOI10.1016/j.psychres.2018.02.054
语种英语
项目资助者Funds of high-level health-technology personnel in Beijing Healthcare System ; National Natural Science Foundation of China
资助项目Funds of high-level health-technology personnel in Beijing Healthcare System[2014-3-097] ; National Natural Science Foundation of China[30770782] ; National Natural Science Foundation of China[81000509]
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000432234600024
出版者ELSEVIER IRELAND LTD
关键词[WOS]Immune Activation Models ; Blood-brain-barrier ; 1st Episode ; Neuropsychological Status ; Inflammatory Cytokines ; Adult Schizophrenia ; Neurotrophic Factor ; Repeatable Battery ; Maternal Infection ; Neuronal Death
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26500
专题健康与遗传心理学研究室
通讯作者Zhang, Xiang-Yang
作者单位1.Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China
2.Weihai Mental Hlth Ctr, Weihai, Peoples R China
3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China
4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
5.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Xiu, Mei-Hong,Wang, Dong,Chen, Song,et al. Interleukin-3, symptoms and cognitive deficits in first-episode drug-naive and chronic medicated schizophrenia[J]. PSYCHIATRY RESEARCH,2018,263:147-153.
APA Xiu, Mei-Hong.,Wang, Dong.,Chen, Song.,Du, Xiang-Dong.,Chen, Da-Chun.,...&Zhang, Xiang-Yang.(2018).Interleukin-3, symptoms and cognitive deficits in first-episode drug-naive and chronic medicated schizophrenia.PSYCHIATRY RESEARCH,263,147-153.
MLA Xiu, Mei-Hong,et al."Interleukin-3, symptoms and cognitive deficits in first-episode drug-naive and chronic medicated schizophrenia".PSYCHIATRY RESEARCH 263(2018):147-153.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Interleukin-3, sympt(236KB)期刊论文作者接受稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xiu, Mei-Hong]的文章
[Wang, Dong]的文章
[Chen, Song]的文章
百度学术
百度学术中相似的文章
[Xiu, Mei-Hong]的文章
[Wang, Dong]的文章
[Chen, Song]的文章
必应学术
必应学术中相似的文章
[Xiu, Mei-Hong]的文章
[Wang, Dong]的文章
[Chen, Song]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Interleukin-3, symptoms and cognitive deficits in first-episode drug-naive and chronic medicated schizophrenia.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。