PSYCH OpenIR  > 健康与遗传心理学研究室
Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction
Wang, Peipei1,2; Jia, Xiuqin3,4; Zhang, Miao1,2; Cao, Yanxiang1,2; Zhao, Zhilian1,2; Shan, Yi1,2; Ma, Qingfeng5; Qian, Tianyi6; Wang, Jingjuan7; Lu, Jie1,2,7; Li, Kuncheng1,2
第一作者Peipei Wang
2018-06-01
发表期刊FRONTIERS IN NEUROLOGY
通讯作者邮箱imaginglu@hotmail.com
ISSN1664-2295
卷号9页码:8
摘要

The mechanisms of motor functional recovery after pontine infarction (PI) remain unclear. Here, we assessed longitudinal changes in gray matter volume (GMV) and examined the relationship between GMV and clinical outcome. Fifteen patients with unilateral PI underwent magnetic resonance imaging and neurological exams five times during a period of 6 months. Another 15 healthy participants were enrolled as the normal control (NC) group and were examined with the same protocol. The MR exam included routine protocol and a 3D T1 -weighted magnetization-prepared rapid acquisition gradient echo scan. Changes in GMV were assessed using voxel-based morphometry. Furthermore, the correlations between GMV changes in regions of interest and clinical scores were assessed. Compared with NCs, the decreased GMVs in the contralateral uvula of cerebellum and the ipsilateral tuber of cerebellum were detected at third month after stroke onset. At the sixth month after stroke onset, the decreased GMVs were detected in the contralateral culmen of cerebellum, putamen, as well as in the ipsilateral tuber/tonsil of cerebellum. Compared with NC, the PI group exhibited significant increases in GMV at each follow-up time point relative to stroke onset. Specifically, the significant GMV increase was found in the ipsilateral middle frontal gyrus and ventral anterior nucleus of thalamus at second week after stroke onset. At first month after stroke onset, the increased GMVs in the ipsilateral middle temporal gyrus were detected. The significant GMV increase in the ipsilateral mediodorsal thalamus was noted at third month after stroke onset. At the end of sixth month after stroke onset, the GMV increase was found in the ipsilateral mediodorsal thalamus, superior frontal gyrus, and the contralateral precuneus. Across five times during a period of 6-month, a negative correlation was observed between mean GMV in the contralateral uvula, culmen, putamen, and ipsilateral tuber/tonsil and mean Fugl-Meyer (FM) score. However, mean GMV in the ipsilateral mediodorsal thalamus was positively correlated with mean FM score. Our findings suggest that structural reorganization of the ipsilateral mediodorsal thalamus might contribute to motor functional recovery after PI.

关键词Pontine Infarction Gray Matter Volume Voxel-based Morphometry Magnetic Resonance Imaging Neuronal Plasticity
DOI10.3389/fneur.2018.00312
语种英语
项目资助者National Natural Science Foundation of China ; Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support ; Beijing Municipal Science & Technology Commission
资助项目National Natural Science Foundation of China[81522021] ; National Natural Science Foundation of China[81671662] ; Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support[ZYLX201609] ; Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support[XMLX201508] ; Beijing Municipal Science & Technology Commission[Z171100000117001]
WOS研究方向Neurosciences & Neurology
WOS类目Clinical Neurology ; Neurosciences
WOS记录号WOS:000433894200001
出版者FRONTIERS MEDIA SA
关键词[WOS]Wallerian Degeneration ; Subcortical Stroke ; Adult Monkeys ; Mediodorsal Nucleus ; Ischemic-stroke ; Brain ; Cortex ; Reorganization ; Lesions ; Rehabilitation
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26501
专题健康与遗传心理学研究室
通讯作者Lu, Jie
作者单位1.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
2.Beijing Key Lab Magnet Resonance Imaging & Brain, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
4.Capital Med Univ, Chaoyang Hosp, Dept Radiol, Beijing, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
6.Siemens Healthcare, Collaborat NE Asia, Beijing, Peoples R China
7.Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Peipei,Jia, Xiuqin,Zhang, Miao,et al. Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction[J]. FRONTIERS IN NEUROLOGY,2018,9:8.
APA Wang, Peipei.,Jia, Xiuqin.,Zhang, Miao.,Cao, Yanxiang.,Zhao, Zhilian.,...&Li, Kuncheng.(2018).Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction.FRONTIERS IN NEUROLOGY,9,8.
MLA Wang, Peipei,et al."Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction".FRONTIERS IN NEUROLOGY 9(2018):8.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Correlation of Longi(504KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Peipei]的文章
[Jia, Xiuqin]的文章
[Zhang, Miao]的文章
百度学术
百度学术中相似的文章
[Wang, Peipei]的文章
[Jia, Xiuqin]的文章
[Zhang, Miao]的文章
必应学术
必应学术中相似的文章
[Wang, Peipei]的文章
[Jia, Xiuqin]的文章
[Zhang, Miao]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。