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Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction
Wang, Peipei1,2; Jia, Xiuqin3,4; Zhang, Miao1,2; Cao, Yanxiang1,2; Zhao, Zhilian1,2; Shan, Yi1,2; Ma, Qingfeng5; Qian, Tianyi6; Wang, Jingjuan7; Lu, Jie1,2,7; Li, Kuncheng1,2
First AuthorPeipei Wang
2018-06-01
Source PublicationFRONTIERS IN NEUROLOGY
Correspondent Emailimaginglu@hotmail.com
ISSN1664-2295
Volume9Pages:8
Abstract

The mechanisms of motor functional recovery after pontine infarction (PI) remain unclear. Here, we assessed longitudinal changes in gray matter volume (GMV) and examined the relationship between GMV and clinical outcome. Fifteen patients with unilateral PI underwent magnetic resonance imaging and neurological exams five times during a period of 6 months. Another 15 healthy participants were enrolled as the normal control (NC) group and were examined with the same protocol. The MR exam included routine protocol and a 3D T1 -weighted magnetization-prepared rapid acquisition gradient echo scan. Changes in GMV were assessed using voxel-based morphometry. Furthermore, the correlations between GMV changes in regions of interest and clinical scores were assessed. Compared with NCs, the decreased GMVs in the contralateral uvula of cerebellum and the ipsilateral tuber of cerebellum were detected at third month after stroke onset. At the sixth month after stroke onset, the decreased GMVs were detected in the contralateral culmen of cerebellum, putamen, as well as in the ipsilateral tuber/tonsil of cerebellum. Compared with NC, the PI group exhibited significant increases in GMV at each follow-up time point relative to stroke onset. Specifically, the significant GMV increase was found in the ipsilateral middle frontal gyrus and ventral anterior nucleus of thalamus at second week after stroke onset. At first month after stroke onset, the increased GMVs in the ipsilateral middle temporal gyrus were detected. The significant GMV increase in the ipsilateral mediodorsal thalamus was noted at third month after stroke onset. At the end of sixth month after stroke onset, the GMV increase was found in the ipsilateral mediodorsal thalamus, superior frontal gyrus, and the contralateral precuneus. Across five times during a period of 6-month, a negative correlation was observed between mean GMV in the contralateral uvula, culmen, putamen, and ipsilateral tuber/tonsil and mean Fugl-Meyer (FM) score. However, mean GMV in the ipsilateral mediodorsal thalamus was positively correlated with mean FM score. Our findings suggest that structural reorganization of the ipsilateral mediodorsal thalamus might contribute to motor functional recovery after PI.

KeywordPontine Infarction Gray Matter Volume Voxel-based Morphometry Magnetic Resonance Imaging Neuronal Plasticity
DOI10.3389/fneur.2018.00312
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support ; Beijing Municipal Science & Technology Commission
Funding ProjectNational Natural Science Foundation of China[81522021] ; National Natural Science Foundation of China[81671662] ; Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support[ZYLX201609] ; Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support[XMLX201508] ; Beijing Municipal Science & Technology Commission[Z171100000117001]
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000433894200001
PublisherFRONTIERS MEDIA SA
WOS KeywordWallerian Degeneration ; Subcortical Stroke ; Adult Monkeys ; Mediodorsal Nucleus ; Ischemic-stroke ; Brain ; Cortex ; Reorganization ; Lesions ; Rehabilitation
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26501
Collection健康与遗传心理学研究室
Corresponding AuthorLu, Jie
Affiliation1.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
2.Beijing Key Lab Magnet Resonance Imaging & Brain, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
4.Capital Med Univ, Chaoyang Hosp, Dept Radiol, Beijing, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
6.Siemens Healthcare, Collaborat NE Asia, Beijing, Peoples R China
7.Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Peipei,Jia, Xiuqin,Zhang, Miao,et al. Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction[J]. FRONTIERS IN NEUROLOGY,2018,9:8.
APA Wang, Peipei.,Jia, Xiuqin.,Zhang, Miao.,Cao, Yanxiang.,Zhao, Zhilian.,...&Li, Kuncheng.(2018).Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction.FRONTIERS IN NEUROLOGY,9,8.
MLA Wang, Peipei,et al."Correlation of Longitudinal Gray Matter Volume Changes and Motor Recovery in Patients After Pontine Infarction".FRONTIERS IN NEUROLOGY 9(2018):8.
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