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Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives
Li, Zhi1,2; Yan, Chao3; Lv, Qin-yu4; Yi, Zheng-hui4; Zhang, Jian-ye5; Wang, Jin-hong5; Lui, Simon S. Y.6; Xu, Yi-feng4; Cheung, Eric F. C.6; Gur, Raquel E.7; Gur, Ruben C.7; Chan, Raymond C. K.1,2
第一作者Zhi Li
2018-05-01
发表期刊SCHIZOPHRENIA RESEARCH
通讯作者邮箱rckchan@psych.ac.cn (r.c.k. chan)
ISSN0920-9964
卷号195页码:215-221
摘要

Despite empirical findings showing that patients with schizophrenia and their unaffected first-degree relatives have deficits in processing monetary incentives, it is unclear whether similar deficits could be demonstrated for affective incentives. Twenty-six patients with schizophrenia and 26 age and gender matched healthy controls; 23 unaffected first-degree relatives and 23 matched healthy controls were recruited to complete a Monetary Incentive Delay (MID) task and an Affective Incentive Delay (AID) task in a 3-Tesla MRI scanner. Hypoactivation in the dorsal striatum when anticipating monetary incentives were found in patients with schizophrenia and their unaffected first-degree relatives compared with healthy controls. Furthermore, patients with schizophrenia showed hyperactivation in the ventral striatum when receiving both monetary and affective incentives. These findings suggest that disorganized striatal function, regardless of incentive types, may be present in patients with schizophrenia and before the onset of illness in their first-degree unaffected relatives. (C) 2017 Elsevier B.V. All rights reserved.

关键词Schizophrenia First-degree Relative Dopamine Neural Circuits
DOI10.1016/j.schres.2017.08.043
语种英语
项目资助者National Science Fund China ; National Basic Research Program of China (Precision Psychiatry Programme) ; Beijing Municipal Science & Technology Commission Grant ; Beijing Training Project for Leading Talents in ST
资助项目National Science Fund China[81571317] ; National Science Fund China[31500894] ; National Basic Research Program of China (Precision Psychiatry Programme)[2016YFC0906402] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for Leading Talents in ST[Z151100000315020]
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000432466700031
出版者ELSEVIER SCIENCE BV
关键词[WOS]Reward Anticipation ; Dorsal Striatum ; Linking Biology ; Activation ; Dopamine ; Prediction ; Psychosis ; Salience ; Phenomenology ; Dissociation
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26503
专题中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.East China Normal Univ, Sch Psychol & Cognit Sci, Key Lab Brain Funct Genom MOE & STCSM, Shanghai, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
5.Shanghai Mental Hlth Ctr, MRI Ctr, Shanghai, Peoples R China
6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
7.Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
推荐引用方式
GB/T 7714
Li, Zhi,Yan, Chao,Lv, Qin-yu,et al. Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives[J]. SCHIZOPHRENIA RESEARCH,2018,195:215-221.
APA Li, Zhi.,Yan, Chao.,Lv, Qin-yu.,Yi, Zheng-hui.,Zhang, Jian-ye.,...&Chan, Raymond C. K..(2018).Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives.SCHIZOPHRENIA RESEARCH,195,215-221.
MLA Li, Zhi,et al."Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives".SCHIZOPHRENIA RESEARCH 195(2018):215-221.
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